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Dortmund, Germany

TU Dortmund University is a university in Dortmund, North Rhine-Westphalia, Germany with over 20,000 students, and over 3,000 staff. It is situated in the Ruhr area, the fourth largest urban area in Europe.The university is highly ranked in terms of its research performance in the areas of physics, electrical engineering, chemistry and economics. Wikipedia.

De Medeiros Varzielas I.,TU Dortmund
Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics | Year: 2011

The exact alignment of the Yukawa structures on multi-Higgs doublet models provides cancellation of tree-level flavour changing couplings of neutral scalar fields. We show that family symmetries can provide a suitable justification for the Yukawa alignment. © 2011 Elsevier B.V.

Spatial division multiplexing has been proposed as an option for further capacity increase of transmission fibers. Application of this concept is attractive only, if cost and energy efficient implementations can be found. In this work, optical amplification and optical filter based signal processing concepts are investigated. Deployment of multi mode fibers as the waveguide type for erbium doped fiber amplifiers potentially offers cost and energy efficiency advantages compared to using multi core fibers in preamplifier as well as booster stages. Additional advantages can be gained from optimization of the amplifier module design. Together with transponder design optimizations, they can increase the attractiveness of inverse spatial multiplexing, which is proposed as an intermediate step. Signal processing based on adaptive passive optical filters offers an alternative approach for the separation of channels at the receiver which have experienced mode coupling along the link. With this optical filter based approach, fiber capacity can potentially be increased faster and more energy efficiently than with solutions relying solely on electronic signal processing. © 2011 Optical Society of America.

Burghoff B.,TU Dortmund
Journal of Biotechnology | Year: 2012

Biotechnological downstream processing faces several challenges, such as dilute product streams and contained target products which are sensitive to heat, oxidation, other chemicals, etc. State-of-the-art separation methods, e.g. chromatography, are not always the best option due to variable yield losses and high costs. Foam fractionation appears as a promising alternative unit operation in biotechnological downstream processing. From its applications in metal industry and on fish farms, it was developed further towards the recovery of phytonutrients, metabolites and proteins. However, no large scale applications of foam fractionation in biotechnological downstream processing exist yet. This is due to the complexity of various biotechnological media, which makes a universalized approach for systematic process design of protein separations difficult. Ongoing research in the fields of process engineering, surface chemistry and protein chemistry can help to close this gap. Although many different substances, such as detergents, have been separated or recovered using foam fractionation, this review focuses mainly on biotechnological applications, more specifically on protein separation. © 2012 Elsevier B.V.

Niemeyer C.M.,TU Dortmund
Angewandte Chemie - International Edition | Year: 2010

conjugation with artificial nucleic acids allows proteins to be modified with a synthetically accessible, robust tag. This attachment is addressable in a highly specific manner by means of molecular recognition events, such as Watson-Crick hybridization. Such DNAprotein conjugates, with their combined properties, have a broad range of applications, such as in high-performance biomedical diagnostic assays, fundamental research on molecular recognition, and the synthesis of DNA nanostructures. This Review surveys current approaches to generate DNA-protein conjugates as well as recent advances in their applications. For example, DNA-protein conjugates have been assembled into model systems for the investigation of catalytic cascade reactions and light-harvesting devices. Such hybrid conjugates are also used for the biofunctionalization of planar surfaces for micro- and nanoarrays, and for decorating inorganic nanoparticles to enable applications in sensing, materials science, and catalysis. © 2010 Wiley-VCH Verlag GmbH &. Co. KGaA,.

Sacca B.,TU Dortmund | Niemeyer C.M.,TU Dortmund
Chemical Society Reviews | Year: 2011

Proteins possess intrinsic functionalities, which have been optimized in billions of years of natural evolution. The conjugation of proteins with artificial nucleic acids allows one to further functionalize proteins with a synthetically accessible, physicochemically robust tag, which is addressable in a highly specific manner by Watson-Crick hybridization. The resulting DNA-protein conjugates can be advantageously used in a variety of applications, ranging from biomedical diagnostics to DNA-based nanofabrication. This critical review provides an overview on chemical approaches to the synthesis of DNA-protein conjugates and their applications in biomolecular nanosciences (96 references). © The Royal Society of Chemistry 2011.

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