Tsumura Co.

Tokyo, Japan

Tsumura Co.

Tokyo, Japan
SEARCH FILTERS
Time filter
Source Type

Patent
Tsumura & Co. | Date: 2016-09-06

Provided are a method of and an apparatus for formulating a multicomponent drug capable of surely making a multicomponent drug meeting criteria for productization with high accuracy into a product. The method and apparatus obtain a chromatogram from an extract or a base of a multicomponent drug, evaluate whether the base meets the criteria for productization based on the obtained chromatogram with high accuracy, and subject the base determined in the high-accuracy evaluating as an accepted one meeting the criteria to dosage form processing, to produce a formulated drug having a given dosage-form.


Patent
Tsumura & Co. | Date: 2016-11-07

Provided are a method of and an apparatus for formulating a multicomponent drug capable of surely making a multicomponent drug meeting criteria for productization with high accuracy into a product. The method and apparatus obtain a chromatogram from an extract or a base of a multicomponent drug, evaluate whether the base meets the criteria for productization based on the obtained chromatogram with high accuracy, and subject the base determined in the high-accuracy evaluating as an accepted one meeting the criteria to dosage form processing, to produce a formulated drug having a given dosage form. The high quality evaluation is realized by performing peak assignment of a target fingerprint obtained from a chromatogram to a reference fingerprint with high accuracy.


Patent
Tsumura & Co. | Date: 2016-10-05

Provided are a method of and an apparatus for formulating a multicomponent drug capable of surely making a multicomponent drug meeting criteria for productization with high accuracy into a product. The method and apparatus obtain a chromatogram from an extract or a base of a multicomponent drug, evaluate whether the base meets the criteria for productization based on the obtained chromatogram with high accuracy, and subject the base determined in the high-accuracy evaluating as an accepted one meeting the criteria to dosage form processing, to produce a formulated drug having a given dosage form. The high quality evaluation is realized by performing peak assignment of a target fingerprint obtained from a chromatogram to a reference fingerprint with high accuracy.


An evaluating apparatus for a pattern, capable of improving of the accuracy and efficiency of evaluation of a multicomponent material, includes a FP preparing part 3 preparing a FP at a specific detection wavelength as a target FP from on a 3D chromatogram of a multicomponent material that is an evaluation target, a peak pattern preparing part 7 preparing a peak pattern for each peak of the target FP and a reference FP that comprises n+1 peaks including n peaks being present on at least one of sides located in front and in the rear of each peak in a time axis direction, a peak assigning part 9 specifying the peaks by comparison of the peak patterns and the UV spectra of the peaks, and an evaluating part 11 evaluating the assigned peaks by comparison with peaks of a plurality of reference FPs.


The object is to contribute to improvement of accuracy and efficiency in evaluation. Provided is a similarity evaluating device for collective data to evaluate similarity between collective data sets in which a plurality of pieces of data are collected. The device includes a patterning part patterning each data of collective data with a selected scale, a matching number extraction part comparing each patterned data in a round-robin to find numbers of matches, and a matching degree determination part finding a degree of matching on the basis of the found numbers of matches with the use of Tanimoto coefficient, thereby evaluating similarity of the collective data simply and quickly.


Patent
Tsumura & Co. | Date: 2014-04-09

An evaluating apparatus, capable of contributing to improve the accuracy and the efficiency of an evaluation of an evaluation target, includes a FP preparing part 3 that prepares a target FP configured by peaks, retention time points and UV spectra thereof detected from a 3D chromatogram of a multicomponent drug that is an evaluation target at a specific wavelength, a reference FP selecting part 5 that selects a reference FP that is appropriate for assigning peaks of the target FP from among a plurality of reference FPs, a peak pattern preparing part 7 that prepares a peak pattern that is configured by, for example, three peaks including two peaks that are present at least on one of sides located in front and rear in a time axis direction for each peak of the target FP and the selected reference FP, a peak assigning part 9 that specifies corresponding peaks by comparing the peak patterns and the UV spectra of the peaks, and an evaluating part that compares and evaluates the assigned peaks and the peaks of the plurality of reference FPs by, for example, MT method.


Patent
Tsumura & Co. | Date: 2016-09-19

Provided are a method of and an apparatus for formulating a multicomponent drug capable of surely making a multicomponent drug meeting criteria for productization with high accuracy into a product. The method and apparatus obtain a chromatogram from an extract or a base of a multicomponent drug, evaluate whether the base meets the criteria for productization based on the obtained chromatogram with high accuracy, and subject the base determined in the high-accuracy evaluating as an accepted one meeting the criteria to dosage form processing, to produce a formulated drug having a given dosage-form. The high-accuracy evaluating is realized by selecting with high accuracy one of reference fingerprints to which peaks of a target fingerprint prepared from the chromatogram are assigned.


Patent
Tsumura & Co. | Date: 2016-09-09

Provided are a method of and an apparatus for formulating a multicomponent drug capable of surely making a multicomponent drug meeting criteria for productization with high accuracy into a product. The method and apparatus obtain a chromatogram from an extract or a base of a multicomponent drug, evaluate whether the base meets the criteria for productization based on the obtained chromatogram with high accuracy, and subject the base determined in the high-accuracy evaluating as an accepted one meeting the criteria to dosage form processing, to produce a formulated drug having a given dosage-form. The high quality evaluation is realized by using fingerprint area segmentation feature values obtained from a fingerprint formed from a chromatogram and segmented into a plurality of areas.


Patent
TSUMURA & Co. | Date: 2014-06-10

Provided is a microorganism detection method which is highly versatile and applicable to both the test for the detection of specified microorganisms and the microbial enumeration test under the same test conditions for Kampo extract preparations and crude drugs containing a variety of antimicrobial substances, is able to effectively reduce the influence of antimicrobial substances in a test sample, and may detect target microorganisms with high precision. This method is a microorganism detection method in a test sample having antimicrobial activity, including a step of preparing a sample liquid containing a test sample having antimicrobial activity and a step of culturing a target microorganism in a culture medium, the method including allowing a (meth) acrylic acid ester-based synthetic adsorbent to act on the sample liquid and/or the culture medium.


Patent
Asahikawa Medical College and TSUMURA & Co. | Date: 2015-09-25

It is an object of the invention to discover a substance that effectively increases the production of adrenomedullin, as well as to provide an adrenomedullin production-enhancing agent utilizing this substance. The adrenomedullin production-enhancing agent is characterized by inclusion of a ginsenoside, a sanshool, and/or a shogaol as active ingredients.

Loading Tsumura Co. collaborators
Loading Tsumura Co. collaborators