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Ueno M.,Tsuchiura Kyodo General Hospital
Dermatology online journal | Year: 2011

A 43-year-old Japanese man with alcoholic liver cirrhosis developed a nodule on the face 1 year prior to presentation. Histopathological examination showed amyloid deposition in the entire dermis, with numerous plasma cells. Nodular primary localized cutaneous amyloidosis is a rare form of amyloidosis, which needs long-term follow-up because of the possibility of the development of systemic amyloidosis. Also, this type of cutaneous amyloidosis may have other complications. Source


Kuroki H.,Tsuchiura Kyodo General Hospital
Kyobu geka. The Japanese journal of thoracic surgery | Year: 2012

A 78-year-old female presented at a nearby hospital with hemorrhage and loss of consciousness. After examination by computed tomography (CT) scan, she was referred to our hospital on suspicion of an impending rupture of the descending thoracic aorta aneurysm. She underwent a 2 stage operation. At the 1st operation, graft replacement of the descending aorta and closing of the aneurysmal wall over the aortoesophageal fistula were performed. On the 2nd postoperative day, intrathoracic esophagogastrostomy was performed by the gastric tube interposition technique. On the 54th postoperative day, she was discharged to a rehabilitation hospital. Source


Tanaka Y.,Tsuchiura Kyodo General Hospital
Breast Cancer | Year: 2010

Background: Although hypercalcemia is a common complication of breast carcinoma (BC), it may be due to primary hyperparathyroidism (pHPT), which has a similar sex or age predilection to that of BC. The rate of underlying asymptomatic pHPT in BC patients with hypercalcemia is exceptionally high, so the clinical data were retrospectively analyzed. Method: To investigate coexistent pHPT in BC patients, the medical records of persons who had undergone surgery for primary BC without bone metastases between October 2004 and March 2008 at the Tsuchiura Kyodo General Hospital were retrospectively reviewed. The corrected serum calcium level was measured in all 243 patients. Ten patients who noted hypercalcemia above 11.0 mg/dl via the corrected serum calcium were selected in order to investigate pHPT. Result: Among the 243 patients investigated, 7 were diagnosed with pHPT, and 5 of those patients required surgical treatment. In all five patients, the parathyroids were pathologically diagnosed to have adenoma. Conclusion: Primary hyperparathyroidism was diagnosed in 2.88% of the BC patients, which was more than expected, in comparison to the incidence of pHPT in adult women, which is 0.04-0.08%. It is important to assess whether pHPT is associated with the treatment of BC. © 2009 The Japanese Breast Cancer Society. Source


Oh Y.,Tokyo Medical and Dental University | Wakabayashi Y.,Tokyo Medical and Dental University | Kurosa Y.,Saku Central Hospital | Ishizuki M.,Tsuchiura Kyodo General Hospital | Okawa A.,Tokyo Medical and Dental University
Journal of Orthopaedic Science | Year: 2014

Background: We have studied stress fractures of the bowed femoral shaft (SBFs) among elderly Japanese for over a decade. On the other hand, severely suppressed bone turnover (SSBT) after long-term bisphosphonates (BPs) use has been considered to be one of the causes of low-energy diaphyseal femoral fractures, often called atypical femoral fractures (AFFs). Some studies have shown that BPs use for more than 5 years is associated with an increased risk of AFFs. Here, we present a report of our SBF case series experienced in the past 15 years in order to examine whether bowing deformity should be considered among the causes of AFFs. Methods: Subjects were 13 Japanese female patients with low-energy femoral shaft fractures. Mean age at injury was 77.0∈years (range 67-88∈years). All patients met the criteria of the AFFs' case definition. The first author treated 11 of the 13 patients over 8 years (2005-2012) based on the concept of SBFs. Regarding the regional characteristics of these patients, 10 were treated at 2 rural hospitals, and 3 were treated at 3 urban hospitals. Retrospectively, we assessed fracture type and location, existence of fracture on the contralateral side, bowing deformity, and duration of BPs use. Results: All 13 cases were AO/OTA type 32-A. Incomplete or previous fracture on the contralateral side was noted in 10 cases. Obvious bowing deformity of the femoral shaft was noted in 12 cases. BPs were taken in 7 cases, only 3 of which involved BPs use for more than 5 years. Conclusions: We experienced 12 cases of low-energy femoral shaft fractures associated with bowing deformity. Six cases were not treated with BPs at all. Stress fractures associated with a femoral shaft bowing deformity do actually exist and should be recognized as another cause of AFFs. © 2014 The Japanese Orthopaedic Association. Source


Ikeda S.,Tsuchiura Kyodo General Hospital
Rinsho byori. The Japanese journal of clinical pathology | Year: 2010

Although ALK-positive lung cancer cases have been recently reported, it is impossible to detect using only morphology technique. Furthermore, though RT-PCR and FISH techniques can be used for detection, they are not practical for screening. We investigated whether ALK-positive lung cancer could be detected using a conventional immunostaining method. Resected lung adenocarcinoma samples from 88 nonsmoker cases were selected and screening was performed using ALK immunostaining in 24 cases that did not have the EGFR or k-ras mutation. We found that the optimal staining condition was treatment using a water bath and detection with a Novo Link Polymer Detection System (Leica microsystems). Of the 24 cases examined, ALK expression was found in 4, of which ALK separated signals were found in 3 using a FISH method. No separated signals were seen in cases with negative immunostaining findings. Detection by immunostaining was found useful for ALK mutated lung cancer cases, though the pretreatment and detection methods utilized are important. Source

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