Lu Y.,Tsingua University
Genes and Development | Year: 2014
Cell type-specific conditional activation of oncogenic K-Ras is a powerful tool for investigating the cell of origin of adenocarcinomas in the mouse lung. Our previous studies showed that K-Ras activation with a CC10(Scgb1a1)-CreER driver leads to adenocarcinoma in a subset of alveolar type II cells and hyperplasia in the bronchioalveolar duct region. However, no tumors develop in the bronchioles, although recombination occurs throughout this region. To explore underlying mechanisms, we simultaneously modulated either Notch signaling or Sox2 levels in the CC10+ cells along with activation of K-Ras. Inhibition of Notch strongly inhibits adenocarcinoma formation but promotes squamous hyperplasia in the alveoli. In contrast, activation of Notch leads to widespread Sox2+, Sox9+, and CC10+ papillary adenocarcinomas throughout the bronchioles. Chromatin immunoprecipitation demonstrates Sox2 binding to NOTCH1 and NOTCH2 regulatory regions. In transgenic mouse models, overexpression of Sox2 leads to a significant reduction of Notch1 and Notch2 transcripts, while a 50% reduction in Sox2 leads to widespread papillary adenocarcinoma in the bronchioles. Taken together, our data demonstrate that the cell of origin of K-Ras-induced tumors in the lung depends on levels of Sox2 expression affecting Notch signaling. In addition, the subtype of tumors arising from type II cells is determined in part by Notch activation or suppression. © 2014 Xu et al.
Zhang J.,Tsingua University |
Kan C.,Tsingua University |
Schwing A.G.,ETH Zurich |
Urtasun R.,TTI Chicago
Proceedings of the IEEE International Conference on Computer Vision | Year: 2013
In this paper we propose an approach to jointly estimate the layout of rooms as well as the clutter present in the scene using RGB-D data. Towards this goal, we propose an effective model that is able to exploit both depth and appearance features, which are complementary. Furthermore, our approach is efficient as we exploit the inherent decomposition of additive potentials. We demonstrate the effectiveness of our approach on the challenging NYU v2 dataset and show that employing depth reduces the layout error by 6% and the clutter estimation by 13%. © 2013 IEEE.
Ma L.,Tsingua University |
Ghelfi P.,CNIT |
Yao M.,Tsingua University |
Berizzi F.,CNIT |
And 2 more authors.
Electronics Letters | Year: 2011
An experimental demonstration of an optical parallelisation scheme for a high-sampling-rate photonic-assisted analogue-to-digital converter (ADC) is presented. By exploiting four-wave mixing in high nonlinear fibre, a tenfold parallelisation of a 9.952GS/s signal is realised with signal-to-noise ratio ranging from 24.94 to 27.53dB, corresponding to effective number of bits (ENOB) from 3.86 to 4.26bits. Capability for ENOB of 6 bits is also permitted, and potentials for parallelisation of larger scale are also discussed. © 2011 The Institution of Engineering and Technology.
"EuPRAXIA will define the missing step towards a new generation of plasma accelerators with the potential for dramatically reduced size and cost," said EuPRAXIA coordinator Ralph Assmann from DESY. "It will ensure that Europe is kept at the forefront of accelerator-based science and applications." The EuPRAXIA consortium includes 16 laboratories and universities from five EU member states. In addition, it includes 18 associated partners from eight countries, involving leading institutes in the EU, Japan, China and the United States. Particle accelerators have evolved over the last 90 years into powerful and versatile machines for discoveries and applications. Today some 30,000 accelerators are operated around the world, among those some of the largest machines built by human mankind. A new technology for particle acceleration has emerged and has demonstrated accelerating fields a thousand times beyond those presently used: Plasma acceleration uses electrically charged plasmas, generated by strong lasers, instead of the usual radio frequency used in conventional accelerators, to boost particles like electrons to high energies. By the end of 2019, EuPRAXIA will produce a conceptual design report for the worldwide first five Giga-Electronvolts plasma-based accelerator with industrial beam quality and dedicated user areas. EuPRAXIA is the required intermediate step between proof-of-principle experiments and versatile ultra-compact accelerators for industry, medicine or science, e.g. at the energy frontier of particle physics as a plasma linear collider. The study will design accelerator technology, laser systems and feedbacks for improving the quality of plasma-accelerated electron beams. Two user areas will be developed for a novel free-electron laser, high-energy physics and other applications. An implementation model will be proposed, including a comparative study of possible sites in Europe, a cost estimate and a model for distributed construction but installation at one central site. As a new large research infrastructure, EuPRAXIA would place Europe at the forefront of the development of novel accelerators driven by the world's most powerful lasers from European industry in the 2020's. The EuPRAXIA consortium has the following participants: Centre National de la Recherche Scientifique (CNRS), Commissariat à l'Énergie Atomique et aux énergies alternatives (CEA) and Synchrotron SOLEIL from France, DESY and the University of Hamburg from Germany, Istituto Nazionale di Fisica Nucleare (INFN), Consiglio Nazionale delle Ricerche (CNR), Agenzia nazionale per le nuove tecnologie, l'energia e lo sviluppo economico sostenible (ENEA) and Sapienza Universita di Roma from Italy and Instituto Superior Técnico (IST) from Portugal, Science & Technology Facilities Council (STFC), University of Manchester, University of Liverpool, University of Oxford, University of Strathclyde and Imperial College London from the UK. Associated partners are: Jiaotong University Shanghai and Tsingua University Beijing from China, Extreme Light Infrastructures - Beams (ELI-B) in Czech Republic, University of Lille in France, High Energy Accelerator Research Organization (KEK), Kansai Photon Science Institute, Japan Atomic Energy Agency, Osaka University and RIKEN Spring-8 Center from Japan, Helmholtz-Institut Jena, Helmholtz-Zentrum Dresden-Rossendorf and Ludwig-Maximillians-Universität München from Germany, Wigner Research Center of the Hungarian Academy of Science in Hungary, University of Lund in Sweden, European Organization for Nuclear Research (CERN) in Switzerland, Center for Accelerator Science and Education at Stony Brook University & Brookhaven National Laboratory (BNL), Lawrence Berkeley National Laboratory (LBNL), SLAC National Accelerator Laboratory and University of California at Los Angeles (UCLA) in the U.S.
Li G.,Tsingua University |
Li G.,Tsinghua National Laboratory for Information Sciences and Technology |
Zhang H.,Tsingua University |
Zhang H.,Tsinghua National Laboratory for Information Sciences and Technology |
And 3 more authors.
IEEE Transactions on Aerospace and Electronic Systems | Year: 2012
An algorithm based on matching pursuit (MP) is proposed for inverse synthetic aperture radar (ISAR) two-dimensional (2-D) imaging of uniformly rotating targets. The ISAR echo is decomposed into many subsignals that are generated by discretizing spatial domain and synthesizing the ISAR data for every discretized spatial position. The subsignals that indeed contribute to the ISAR echo are selected by the MP, and their coefficients represent the superresolution image. The target rotation rate is estimated by combining MP with maximum contrast search. © 1965-2011 IEEE.