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Bhatnagar P.,Guru Ramdas Khalsa Institute of Science and Technology | Dhote V.,Truba Institute of Pharmacy | Mahajan S.C.,Mahakal Institute of Pharmaceutical Studies | Mishra D.K.,P.A. College
Current Drug Delivery | Year: 2014

The solubility of drugs is one of the most challenging aspects in developing formulations for novel drug discovery. Myriad of approaches have been developed and tested to overcome the associated intricacies involved with poor water soluble drugs. Out of the available technologies, solid dispersion (SD) method that significantly enhances the solubility and bioavailability by reducing particle size to a micro-molecular level is often viewed as a promising strategy. Although conceptual basis of manufacturing processes involved in SD method have been reported, formulation characteristics addressing solubility issues remains yet elusive. The current review portray the historical milestones, classification, probable mechanisms for enhancement of solubility, manufacturing processes at commercial level along with pioneer breakthroughs in field that enunciates the versatile pharmaceutical application for categories including anti-cancer and anti-retroviral drugs. Besides, our article also highlights the translational implications of drug development by SD method hitherto unreported. © 2014 Bentham Science Publishers.

Jain N.,Sagar Institute of Research and Technology Pharmacy | Jain R.,Sagar Institute of Research and Technology Pharmacy | Thakur N.,Sagar Institute of Research and Technology Pharmacy | Gupta B.P.,Sagar Institute of Research and Technology Pharmacy | And 3 more authors.
Asian Journal of Pharmaceutical and Clinical Research | Year: 2010

Nanotechnology is relatively new, and although the full scope of contributions of these technological advances in the field of human health care remains unexplored, recent advances suggest that nanotechnology will have a profound impact on disease prevention, diagnosis, and treatment. Nanotechnology based delivery system would allow faster drug absorption, controlled dosage release into the human body and would have other unique properties of minimizing side-effects by eliminating requirement of co-solvent as used in conventional dosage form. Further, drugs that have side-effects due to triggering an immune system response can be wrapped in nanoparticle coating and prevent immune system from recognizing and reacting to a foreign substance. It is an ideal targeting system should have long circulating time, it should be present at appropriate concentrations at the target site, and it should not lose its activity or therapeutic efficacy while in circulation.

Chandel H.S.,Truba Institute of Pharmacy | Pathak A.K.,Barkatullah University | Tailang M.,Peoples Institute of Pharmacy and Research Center
Research Journal of Pharmacy and Technology | Year: 2011

The present paper reports characterization of eight herbal drugs individually and in polyherbal formulations by microscopy. The characteristic microscopical structures of the individual drugs were compared to the prepared polyherbal in -house formulations and three polyherbal marketed formulations- Madhumehari, Madhuhari, Madhushoonya. C. longa was characterized on the basis of fragments of parenchyma cells filled with gelatinized starch, covering trichomes and fragments of spirally thickened vessels. A. indica was characterized on the basis of anomocytic stomata, thick walled covering trichome. Fibrovascular bundles and rosette type calcium oxalate crystals were seen in E. officinalis. In M. charantia spiral and reticulate vessels and prism type calcium oxalate crystals were observed. In T. foenum powder layers of covered thick walled cells containing alurone grains and columnar palisade with externally thick cuticle cell flat at base were observed. Oval rounded starch grains and some special structures were seen in E. jambolana. Rhomboidal crystals of calcium oxalate and tanniferous duct were the characteristic microscopical structures in P. marsupium and G. sylvestre was characterized on the basis of paracytic stomata and broken pieces of trichomes. © RJPT All right reserved.

Mishra D.K.,IPS ACADEMY | Dhote V.,Truba Institute of Pharmacy | Bhargava A.,Dr Hari Singh Gour University | Jain D.K.,IPS ACADEMY | Mishra P.K.,Dr Hari Singh Gour University
Drug Delivery and Translational Research | Year: 2015

Solid dispersion has emerged as a method of choice and has been extensively investigated to ascertain the in vivo improved performance of many drug formulations. It generally involves dispersion of drug in amorphous particles (clusters) or in crystalline particles. Comparatively, in the last decade, amorphous drug–polymer solid dispersion has evolved into a platform technology for delivering poorly water-soluble small molecules. However, the success of this technique in the pharmaceutical industry mainly relies on different drug–polymer attributes like physico-chemical stability, bioavailability and manufacturability. The present review showcases the efficacy of amorphous solid dispersion technique in the research and evolution of different drug formulations particularly for those with poor water soluble properties. Apart from the numerous mechanisms of action involved, a comprehensive summary of different key parameters required for the solubility enhancement and their translational efficacy to clinics is also emphasized. © 2015, Controlled Release Society.

Jain R.,Suresh Gyan Vihar University | Jain V.,Sagar Institute of Research and Technology Pharmacy | Jain N.,Sagar Institute of Research and Technology Pharmacy | Jain D.K.,Truba Institute of Pharmacy | Jain S.,Sagar Institute of Research and Technology Pharmacy
Journal of Applied Pharmaceutical Science | Year: 2012

The present work describes a novel, accurate, sensitive and economic safe spectrophotometric method was developed by application of hydrotropy, using 8 M Urea solution as hydrotropic solubilizing agent, for the quantitative determination of poorly watersoluble lomefloxacin HCl in tablet dosage form. There were more than 43 times enhancements in the solubility of lomefloxacin HCl increases in hydrotropic solution as compared to solubilities in distilled water. Lomefloxacin HCl shows maximum absorbance at 281 nm. Urea and other tablets excipents did not show any absorbance above 230 nm, and thus no interference in the estimation was seen. Lomefloxacin HCl was obeyed Beer,s law in the concentration range of 5 to 25μg/ml (r2= 0.9998) in hydrotropic solvent with mean recovery ranging from 98.03±0.65 to 98.59±0.32%. Proposed method is new, simple, economic, safe, rapid, accurate and reproducible. The developed methods were validated according to ICH guidelines and values of accuracy, precision and other statistical analysis were found to be in good accordance with the prescribed values. The method can be used for routine analysis in both research laboratories, and pharmaceutical and chemical industries to analyze the drugs without the use of organic solvents thus make the environment eco-friendly.

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