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Troy, MI, United States

Toxtli C.,West Virginia University | Almani N.,University of California at Santa Barbara | Flores-Saviaga C.,National Autonomous University of Mexico | Aguilar F.,National Autonomous University of Mexico | And 7 more authors.
Proceedings of the ACM Conference on Computer Supported Cooperative Work, CSCW | Year: 2016

Online bots are quickly becoming important collaborators with humans in tackling issues in healthcare, politics, and even activism. Recently, non-profits have used many bots in place of their human members to scaffold collaborations with citizens. However, this shift invites new challenges: it is difficult for outsiders to understand the joint effort that bots have now initiated with humans, limiting the goals reached collectively. To help non-profits coordinate the volunteers recruited by online bots, we propose BotViz. BotViz is a new online platform that via data visualizations provides outsiders a clear understanding of the interactions of bots with volunteers. Our data visualization presents two benefits related to traditional interfaces: 1) Diversity, wherein people can understand the diversity of the volunteers, especially their unique strengths; 2) Stalling, wherein people who may be delaying the collective effort triggered by bots can be easily identified by volunteers. Together, our data visualizations point to a future where humans and online bots can better collaborate in order to have large scale impact. Source

Khakoo M.A.,California State University, Fullerton | Orton D.,California State University, Fullerton | Hargreaves L.R.,California State University, Fullerton | Meyer N.,Troy High School
Physical Review A - Atomic, Molecular, and Optical Physics | Year: 2013

Low-energy differential and integral cross sections for the electron-impact vibrational excitation of tetrahydrofuran are presented. The data concern four features in the vibrational excitation electron energy-loss spectrum of tetrahydrofuran over the energy-loss range of 0-0.9 eV. The results show weak influence from long-range dipole interactions, being mainly isotropic. Comparison with earlier work is presented. © 2013 American Physical Society. Source

Tang Y.,Oakland University | Zeng X.,Oakland University | Liang J.,Troy High School
Journal of Chemical Education | Year: 2010

Surface plasmon resonance (SPR) has become an important optical biosensing technology in the areas of biochemistry, biology, and medical sciences because of its real-time, label-free, and noninvasive nature. The high cost of commercial devices and consumables has prevented SPR from being introduced in the undergraduate laboratory. Here, we present an affordable homemade SPR device with all of its components accessible to visualization. This design allows ease of integration with electrochemistry and makes the device suitable for education. We describe a laboratory experiment in which students examine the relationship between the SPR angle and the solution refractive index at the interface and perform a coupled SPR-electrochemistry experiment. Students also study the antibody-antigen binding activity. Most of the experimental work was done as a project by a grade 12 high-school student under proper supervision. We believe that the SPR device and the SPR laboratory will enhance undergraduate chemical education by introducing students to this important modern instrumentation and will help students to learn and understand the molecular interactions occurring at interfaces. © 2010 The American Chemical Society and Division of Chemical Education, Inc. Source

Kim N.,Troy High School | Fuentes E.J.,CCOM | Fuentes E.J.,Holden Comprehensive Cancer Center | Mallinger A.,University of Kansas | And 2 more authors.
Cell Cycle | Year: 2010

During cell proliferation, protein degradation is strictly regulated by the cell cycle and involves two complementary ubiquitin ligase complexes, the SCF (Skp, Cullin, F-box) and APC/C (Anaphase Promoting Complex/Cyclosome) ubiquitin ligases. SCF ligases are constitutively active and generally target only proteins after they have been selected for degradation, usually by phosphorylation. In contrast, APC/C complexes are themselves activated by phosphorylation and their substrates contain a targeting signal known as degron, a consensus amino acid sequence such as a D-Box. SCF complexes degrade proteins during the G1 phase. However, as DNA synthesis begins, the SCF complexes are degraded and APC/C complexes are activated. APC-2, a protein crucial to cell division, initiates anaphase by triggering the degradation of multiple proteins. This study explores an unexpected interaction between APC-2 and SCFFBG1. We found that FBG1 is a promiscuous ubiquitin ligase with many partners. Immunoprecipitation experiments demonstrate that FBG1 and APC2 interact directly. Mutagenesis-based experiments show that this interaction requires a D-Box found within the FBG1 F-box domain. Unexpectedly, we demonstrate that co-expression with FBG1 increases total APC2 levels. However, free APC2 is decreased, inhibiting cell proliferation. Finally, FACS analysis of cell populations expressing different forms of FBG1 demonstrate that this ubiquitin ligase induces S-phase arrest, illustrating the functional consequences of the interaction described. In summary, we have discovered a novel APC2 inhibitory activity of FBG1 independent from its function as ubiquitin ligase, providing the basis for future studies of FBG1 in aging and cancer. © 2010 Landes Bioscience. Source

Khakoo M.A.,California State University, Fullerton | Hong L.,California State University, Fullerton | Kim B.,Troy High School | Winstead C.,California Institute of Technology | McKoy V.,California Institute of Technology
Physical Review A - Atomic, Molecular, and Optical Physics | Year: 2010

We report measured and calculated results for elastic scattering of low-energy electrons by ethyl vinyl ether (ethoxyethene), a prototype system for studying indirect dissociative attachment processes that may play a role in DNA damage. The integral cross section displays the expected π* shape resonance. The agreement between the calculated and measured cross sections is generally good. © 2010 The American Physical Society. Source

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