Yu M.-C.,Chang Gung Childrens Hospital |
Lo F.-S.,Chang Gung Childrens Hospital |
Yu M.-K.,Changhua Christian Hospital |
Huang W.-H.,Chang Gung Memorial Hospital |
And 3 more authors.
European Journal of Pediatrics | Year: 2012
People with type 1 diabetes mellitus are at an increased risk of cardiovascular mortality. Studies comparing arterial stiffness between subjects with type 1 diabetes and nondiabetic controls have provided controversial findings.We investigated brachial-ankle pulse wave velocity (baPWV) in 87 teenagers with type 1 diabetes mellitus and in 21 matched healthy controls. Our data show that baPWV was not increased in teenagers after a median illness of 5 years. © Springer-Verlag 2011.
Janckila A.J.,University of Louisville |
Lin H.-F.,TriService General Hospital |
Wu Y.-Y.,TriService General Hospital |
Ku C.-H.,TriService General Hospital |
And 6 more authors.
Clinica Chimica Acta | Year: 2011
Objective: This study was undertaken to determine the association between serum tartrate-resistant acid phosphatase 5a (TRACP5a) and cardiovascular disease (CVD) risk. Methods: Four hundred patients were enrolled including, 291 asymptomatic subjects grouped by the number of traditional risk factors, 36 patients undergoing cardiac arteriography, 34 undergoing percutaneous cardiac intervention, and 39 with acute myocardial infarction. Serum was collected at baseline and, in arteriograpy and intervention groups, periodically for 1. week afterward. In addition to laboratory and clinical evaluation for risk assessment, serum TRACP5a, C-reactive protein (CRP) and interleukin-6 (IL-6) were determined. Results: All biomarkers rose with increasing CVD risk. Only serum TRACP5a, logCRP and cholesterol were elevated in symptomatic patients. Serum TRACP5a was higher in men and correlated with age, logCRP, logIL-6 and log-triglycerides, and in symptomatic patients, with the number of diseased coronary arteries. IL-6 and CRP showed acute phase responses, whereas TRACP5a did not change over 1. week after arteriography or intervention. After adjustment for all other variables and risk factors, TRACP5a and logCRP were the only biomarkers to associate with symptomatic disease. TRACP5a was more specific than CRP to predict myocardial infarction among all subjects. Conclusions: Serum TRACP5a is a macrophage-derived inflammation marker associated with CVD risk, and with coronary vessel disease and its severity and may be a useful marker for screening and assessment of CVD risk. © 2011.
Chu H.,Institute of Aerospace and Undersea Medicine |
Ma H.-I.,Triservice General Hospital |
Hueng D.-Y.,Triservice General Hospital |
Hueng D.-Y.,National Defense Medical Center
Neurology India | Year: 2012
Objective: Decompressive hemicraniectomy is accepted as the most effective life-saving treatment for malignant middle cerebral artery (MCA) infarction. However, the outcome remains hard to predict. This study examined the efficacy of using the Glasgow Coma Scale (GCS) and Acute Physiology and Chronic Health Evaluation (APACHE) II scores before emergency craniectomy for predicting clinical outcome in malignant MCA infarction. Materials and Methods: Seventy-nine consecutive patients with malignant MCA infarction treated from January 2006 to October 2010 were retrospectively analyzed. The GCS and APACHE II scores within the first 24 h of neurological deterioration or before decompressive hemicraniectomy, were used to predict short-term functional outcome rated by the modified Rankin Scale (mRS). The receiver operating characteristic (ROC) curve was obtained to determine the accuracy and best cut-off value for each scoring system. Results: At 6 months, there was dramatic life-saving effect of surgery, with a significant reduction in mortality rate (from 71% to 19%, P < 0.001). After the ROC analysis, cut-off values of pre-operative GCS > 8 (P = 0.003) and APACHE II <13 (P = 0.006) were sufficiently sensitive and specific to predict favorable outcome (mRS 0-3). Conclusions: Pre-operative GCS and APACHE II scores are useful tools in predicting outcomes for patients with malignant MCA infarction who underwent decompressive hemicraniectomy. Copyright © Wolters Kluwer 2012.
PubMed | Cheng Hsin General Hospital, TriService General Hospital, China Medical University at Taichung, Post University and Ching Cheng High School
Type: Journal Article | Journal: Molecular medicine reports | Year: 2015
Chitosan and Agaricus blazei Murill (ABM) extracts possess antitumor activities. The aim of the present study was to investigate whether chitosan, ABM extract or the two in combination were effective against tumors in tumorbearing mice. The mice were subcutaneously injected with SK-Hep 1 cells and were then were divided into the following six groups: Group 1, control group; group 2, chitosan 5 mg/kg/day; group 3, chitosan 20 mg/kg/day; group 4, ABM (246 mg/kg/day) and chitosan (5 mg/kg/day) combined; group 5, ABM (984 mg/kg/day) and chitosan (20 mg/kg/day) combined; and group 6, ABM (984 mg/kg/day). The mice were treated with the different concentrations of chitosan, ABM or combinations of the two for 6 weeks. The levels of glutamic oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT) and vascular endothelial growth factor (VEGF), and tissue histopathological features were examined in the surviving animals. Based on the results of the investigation, the treatments performed in groups 2, 3 and 4 were identified as being capable of reducing the weights of the tumors, however, group 4, which was treated with chitosan (5 mg/kg/day) in combination with ABM (246 mg/kg/day) was able to reduce the levels of GOT and VEGF. As a result, treatment with chitosan in combination with ABM may offer potential in cancer therapy and requires further investigation.
Chiang H.-H.,Triservice General Hospital |
Lin L.,University of California at San Francisco |
Lee T.S.-H.,National Taiwan Normal University
Geriatrics and Gerontology International | Year: 2016
Aim: Happiness is an important indicator of mental and physical health. It has been emphasized as one kind of well-being, and its definition varies from culture to culture. The main objective of the present study was to examine the psychometric integrity and dimensions of the Chinese Happiness Inventory (CHI) in relation to scores on Ryff's Psychological Well-Being Scale among retired older people in Taiwan. Methods: A cross-sectional study was carried out at social service centers in Taipei, Taiwan. Retired adults gave informed consent from September to November 2010, and completed a package of structured questionnaires measuring happiness and psychological well-being. Internal consistency, the factor structure of the CHI and criterion validity were assessed. Results: Results from an exploratory factor analysis showed a three-factor solution for the CHI. These factors were named Positive Affect, Life Satisfaction and Interpersonal Relationships. Internal consistency coefficients were 0.95 (Positive Affect), 0.91 (Life Satisfaction), 0.85 (Interpersonal Relationships) and 0.97 (total scale). The results of a canonical correlation analysis showed the presence of a strong relationship between CHI and Ryff's Psychological Well-Being Scale (r = 0.69), and that two canonical variates could be derived from the relationship between them. Conclusions: The results show that the CHI is a three-dimensional scale with high reliability and validity. The construct of happiness emphasizes relationships in relation to others and environment rather than autonomy in this sample. Although the components of happiness might be similar for Positive Affect and Life Satisfaction, their weights for Interpersonal Relationships should be considered when measuring happiness in different cultures. Geriatr Gerontol Int 2016; 16: 865–872. © 2015 Japan Geriatrics Society
PubMed | Triservice General Hospital, University of California at San Francisco and National Taiwan Normal University
Type: Journal Article | Journal: Geriatrics & gerontology international | Year: 2016
Happiness is an important indicator of mental and physical health. It has been emphasized as one kind of well-being, and its definition varies from culture to culture. The main objective of the present study was to examine the psychometric integrity and dimensions of the Chinese Happiness Inventory (CHI) in relation to scores on Ryffs Psychological Well-Being Scale among retired older people in Taiwan.A cross-sectional study was carried out at social service centers in Taipei, Taiwan. Retired adults gave informed consent from September to November 2010, and completed a package of structured questionnaires measuring happiness and psychological well-being. Internal consistency, the factor structure of the CHI and criterion validity were assessed.Results from an exploratory factor analysis showed a three-factor solution for the CHI. These factors were named Positive Affect, Life Satisfaction and Interpersonal Relationships. Internal consistency coefficients were 0.95 (Positive Affect), 0.91 (Life Satisfaction), 0.85 (Interpersonal Relationships) and 0.97 (total scale). The results of a canonical correlation analysis showed the presence of a strong relationship between CHI and Ryffs Psychological Well-Being Scale (r=0.69), and that two canonical variates could be derived from the relationship between them.The results show that the CHI is a three-dimensional scale with high reliability and validity. The construct of happiness emphasizes relationships in relation to others and environment rather than autonomy in this sample. Although the components of happiness might be similar for Positive Affect and Life Satisfaction, their weights for Interpersonal Relationships should be considered when measuring happiness in different cultures. Geriatr Gerontol Int 2016; 16: 865-872.
Lo H.-C.,Tao Yuan Armed Forces General Hospital |
Lo H.-C.,Triservice General Hospital |
Hung S.-T.,Tao Yuan Armed Forces General Hospital |
Kuo D.-P.,Tao Yuan Armed Forces General Hospital |
And 2 more authors.
Journal of Shoulder and Elbow Surgery | Year: 2016
Background: This study investigated diffusion-weighted (DWI) magnetic resonance imaging (MRI) as an alternative to fat-suppressed T2-weighted imaging (FS-T2WI) for assessment of partial-thickness rotator cuff tears (RCTs). Methods: Patients with arthroscopy proven partial-thickness RCTs who also received MRI (FS-T2WI and DWI) before surgery were prospectively included. Receiver operating characteristic curves were used to compare DWI vs. FS-T2WI using lesion-to-muscle signal intensity ratios. A cutoff point for predicting partial-thickness tears was determined using the Youden index. Results: Included were 146 patients, with a mean age of 48.3 years (range, 19-86 years), of whom 43 had full-thickness RCTs, 67 had partial-thickness RCTs, and 36 had no tears. Areas under receiver operating characteristic curves for diagnosing partial-thickness tears were significantly higher for DWI (0.910) than for FS-T2WI (0.822, P = .016). Lesion-to-muscle signal intensity ratio cutoff values were 1.06 for DWI vs. 1.65 for FS-T2WI, respectively. The sensitivity and accuracy of DWI (89.1% [98 of 110] and 87.7% [128 of 146], respectively) for diagnosing partial-thickness and full-thickness tears were higher than for FS-T2WI (65.5% [72 of 110] and 72.6% [106 of 146], respectively). FS-T2WI, however, had higher specificity (94.4% [34 of 36]) than DWI (83.3% [30 of 36]). Conclusions: DWI is more accurate and sensitive than FS-T2WI for diagnosing partial-thickness RCTs. © 2016 Journal of Shoulder and Elbow Surgery Board of Trustees.
Shih H.-L.,TriService General Hospital |
Tseng H.-T.,National Taipei University of Nursing and Health Sciences |
Lo Y.-F.,Medical Intensive Care Unit |
Pan H.-H.,TriService General Hospital
Journal of Nursing and Healthcare Research | Year: 2015
Background: The caring behavior of nursing staff critically influences the quality of care received by end‐stage cancer patients. Better understanding the caring behavior of nurses toward end‐stage cancer patients and providing suitable education and instruction on caring behavior to these nurses may enhance the quality of life, wellbeing, and dignity and decrease the suffering of end‐stage cancer patients. Purpose: The aim of this study was to explore the level of familiarity among nursing staff with caring behaviors and its related factors with regard to end‐stage cancer patients. Methods: We applied a cross‐sectional study design that targeted the nursing staff of adult inpatient wards at a medical center in northern Taiwan. A purposive sampling method was used and a self‐structured questionnaire on nursing caring behavior was used to collect data from 118 nursing staff. Results: The average scores for physical caring behavior were higher than those for psychological, social, spiritual, and integrated care. The division of the wards and prior participation in related courses were identified as important predictors of integrated and physical‐care behavior. The number of patients, the division of the wards, and prior participation in related courses were all identified as important predictors of psychological caring behavior. Finally, prior participation in related courses was an important predictor of social and spiritual‐ caring behavior. Conclusions / Implications for Practice: The results of this study may be referenced in the planning of nursing education training programs related to caring behavior with regard to end‐stage cancer patients. The results may further be applied to elevate the quality of care provided by nursing staff to their end‐stage cancer patients. © 2015, (publisher). All rights reserved.
Chung R.-H.,National Health Research Institute |
Tsai W.-Y.,National Health Research Institute |
Hsieh C.-H.,Triservice General Hospital |
Hung K.-Y.,National Health Research Institute |
And 2 more authors.
Genetic Epidemiology | Year: 2015
Simulation tools that simulate sequence data in unrelated cases and controls or in families with quantitative traits or disease status are important for genetic studies. The simulation tools can be used to evaluate the statistical power for detecting the causal variants when planning a genetic epidemiology study, or to evaluate the statistical properties for new methods. We previously developed SeqSIMLA version 1 (SeqSIMLA1), which simulates family or case-control data with a disease or quantitative trait model. SeqSIMLA1, and several other tools that simulate quantitative traits, do not specifically model the shared environmental effects among relatives on a trait. However, shared environmental effects are commonly observed for some traits in families, such as body mass index. SeqSIMLA1 simulates a fixed three-generation family structure. However, it would be ideal to simulate prespecified pedigree structures for studies involving large pedigrees. Thus, we extended SeqSIMLA1 to create SeqSIMLA2, which can simulate correlated traits and considers the shared environmental effects. SeqSIMLA2 can also simulate prespecified large pedigree structures. There are no restrictions on the number of individuals that can be simulated in a pedigree. We used a blood pressure example to demonstrate that SeqSIMLA2 can simulate realistic correlation structures between the systolic and diastolic blood pressure among relatives. We also showed that SeqSIMLA2 can simulate large pedigrees with large chromosomal regions in a reasonable time frame. © 2014 WILEY PERIODICALS, INC.
Chiang Y.-C.,Kaohsiung Armed Forces General Hospital |
Chiang Y.-C.,Taichung Veterans General Hospital |
Lee C.-H.,Taichung Veterans General Hospital |
Chen W.-H.,Taichung Veterans General Hospital |
And 2 more authors.
World Neurosurgery | Year: 2016
Background Paraplegia after intracranial aneurysmal subarachnoid hemorrhage (SAH) is a rare condition, and its pathogenesis is still unclear. Case Description We present a case of a ruptured basilar dissecting aneurysm treated with the stent-assisted coiling procedure. Progressive weakness of the lower limbs developed within 5 days postoperatively. Spinal magnetic resonance image showed SAH accumulation in the lumbosacral area. Emergency lumbar drainage was performed, and the patient's symptoms improved dramatically. Conclusions To the best of our knowledge, this is the first report to describe the successful treatment of paraplegia after intracranial aneurysmal SAH. © 2016 Elsevier Inc. All rights reserved.