Tripura, India
Tripura, India

Tripura University is the main public/central government university of the Indian state of Tripura. Tripura University ranked 4th position in Eastern and 43rd position in all India according to India Today – Nielsen University Ranking Survey 2014 published in India Today on June 30, 2014. Wikipedia.

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Ghosh R.,Tripura University | De B.,Regional Institute of Pharmaceutical Science and Technology
International Journal of Pharmaceutical Sciences Review and Research | Year: 2013

Imidazole is a planar, five membered heteroaromatic molecule with pyrrole type and pyridine type annular nitrogens. Several approaches are available for synthesis of imidazoles from alpha halo ketones, aminonitrile, aldehyde etc. Reactivity of imidazole and benzimidazole is referred from sets of resonance structure in which the dipolar contributors have finite importance. Electrophilic substitution takes place at the 2nd, 4th and 5th position in the imidazole ring, it is much less likely to become involved in nucleophilic substitution reaction unless there is a strongly electron withdrawing substituents elsewhere in the ring. This interesting group of heterocyclic compound has diverse biological activities such as antimicrobial, anticancer, analgesic, anti-inflammatory, antiviral, anthelmintic, anticonvulsant, antiulcer, anti-allergic activity etc. In the present article we review the various synthetic approaches, chemistry and biological activities reported by researchers throughout the world on imidazole.

Bhattacharjee S.,Tripura University | Pal S.,Tripura University
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2014

Objectives: Alteration in lipid profiles and increased levels of oxidative stress have been implicated in the cardiotoxicity induced by arsenic. Selenium and vitamin E against metal-induced cytotoxicity have been showed protective effects and well documented. However, the effectiveness of them to reduce arsenic-induced cardiotoxicity in has not yet been evaluated. So, the present work was undertaken to investigate the cardio protective effects of them against arsenic-induced cardiotoxicity. Methods: In the present study, intraperitoneal dose of arsenic at 7.2mg/kg b.w./day for 30 days was used in Swiss albino mice as cardiotoxicant. Selenium at a dose of 10 μg/k.g./day and vitamin E at a dose of 20 mg/k.g./day for last 14 days of arsenic treatment were used separately and in combination (orally). They were studied in response to control and antioxidant control groups. Results: Sub-acute arsenic exposure resulted in decrease in antioxidant enzyme activities like superoxide dismutase, catalase, glutathione reductase, glutathione S-tranferase, glutathione peroxidase activities and elevated transaminase activities, cholesterol, triglycerides, low density lipoprotein and uric acid level in serum. Additionally, arsenic treatment increased protein carbonyl content, free hydroxyl radical and nitric acid formation in cardiac tissue. Other enzyme activities such as xanthine oxidase, nicotinamide adenine dinucleotide phosphate-oxidase, γ-glutamyl transpeptidase in cardiac tissue were also increased by arsenic. Conclusion: Appreciable beneficial effects of selenium and vitamin E co-administration against arsenic-induced changes in biochemical and histopathological parameters indicate that supplementation of vitamin E along with micronutrient selenium has anti-oxidative as well as antilipidemic effects against arsenic-induced cardiotoxicity.

Kumar M.S.,Tripura University | Das A.P.,Tripura University
Advances in Colloid and Interface Science | Year: 2017

At present, various diagnostic and therapeutic approaches are available for urinary tract infections. But, still the quest for development of more rapid, accurate and reliable approach is an unending process. The pathogens, especially uropathogens are adapting to new environments and antibiotics day by day rapidly. Therefore, urinary tract infections are evolving as hectic and difficult to eradicate, increasing the economic burden to the society. The technological advances should be able to compete the adaptability characteristics of microorganisms to combat their growth in new environments and thereby preventing their infections. Nanotechnology is at present an extensively developing area of immense scientific interest since it has diverse potential applications in biomedical field. Nanotechnology may be combined with cellular therapy approaches to overcome the limitations caused by conventional therapeutics. Nanoantibiotics and drug delivery using nanotechnology are currently growing areas of research in biomedical field. Recently, various categories of antibacterial nanoparticles and nanocarriers for drug delivery have shown their potential in the treatment of infectious diseases. Nanoparticles, compared to conventional antibiotics, are more beneficial in terms of decreasing toxicity, prevailing over resistance and lessening costs. Nanoparticles present long term therapeutic effects since they are retained in body for relatively longer periods. This review focuses on recent advances in the field of nanotechnology, principally emphasizing diagnostics and therapeutics of urinary tract infections. © 2017.

Das M.,Tripura University | Manna K.,Tripura University
Journal of Toxicology | Year: 2016

Cancer is an inevitable matter of concern in the medicinal chemistry era. Chalcone is the well exploited scaffold in the anticancer domain. The molecular mechanism of chalcone at cellular level was explored in past decades. This mini review provides the most recent updates on anticancer potential of chalcones. © 2016 Manik Das and Kuntal Manna.

Das M.,Tripura University | Manna K.,Tripura University
Current Bioactive Compounds | Year: 2015

Cyclohexenone derivatives have been found to play pivotal role in the field of medicinal chemistry. They are embedded in several bioactive natural products like carvotacetones, phorbasins, antheminones and gabosines which are well known anchor for their biological activity like antitumor, antiplasmodial, antileishmanial and other activities. Therefore, the reported biological activity of cyclohexenone derivatives is coupled up with explanation. This mini review article summarizes the biological potential of bioactive cyclohexenone derivatives and their mechanism of action reported over the past few decades. © 2015 Bentham Science Publishers.

Langmuir-Blodgett (LB) films of N,N′-dioctadecyl thiacyanine perchlorate (TC18) and octadecyl rhodamine B chloride (RhB18) and their mixtures in the presence and absence ofclay mineral layers were investigated by recording surface pressure-area (π-A) isotherms and by UV-vis and fluorescencespectroscopies. The (π-A) isotherms of TC18, RhB18, and their mixtures are characteristic of liquid expanded state behavior with repulsive interactions between the two cationic dyes. In the presence of laponite, the(π-A) isotherms show liquid expanded and condensed-state behavior. In laponite dispersions and in monolayers, TC18 has a strong tendency to aggregate with formation of H- and J- aggregates. The absorption and fluorescence maxima of the monomers in the films are at 435 nm and at 480 nm; H-dimers have an absorption maximum around 410 nm and do not fluoresce. J-dimers are present in all the films with absorption maximum at461 nm and fluorescence at 463 nm. RhB18 is mainly present as monomers in the LB films with an absorption maximum at 576 nm and fluorescence at 595 nm. Fluorescence resonance energy transferfrom TC18 to RhB18 has been observed in clay dispersions and in films with and without laponite. The optimum condition for TC18→RhB18 fluorescence energy transfer in the films is 90 mol% TC18 p 10 mol % RhB18. © 2010 American Chemical Society.

Tripathy B.C.,Institute of Advanced Study in Science and Technology | Debnath S.,Tripura University
Journal of Intelligent and Fuzzy Systems | Year: 2013

In this paper we introduce the notion of γ-open sets and γ-continuous functions in fuzzy bitopological spaces. We examine some basic properties and prove some characterization theorems for the said functions. It is observed that every pairwise fuzzy γ-continuous functions is pairwise fuzzy precontinuous but the converse not true. © 2013 - IOS Press and the authors. All rights reserved.

Folk people of Tripura, a small state of Northeast India, rely on their own traditional knowledge of phenological indicators for predicting the weather, to help plan their agroforestry activities and for disaster prevention. One such prediction relates to the phenology of Nyctanthes arbor-tristis L., night-flowering jasmine, which helps them to forecast the onset of heavy rainfall. During 2007-2009, a comprehensive study was initiated to document the predictive accuracy of this indicator, through conversations and interviews with village members, observation and reviewing the older literature. The researchers found that the flowering of Nyctanthes arbor-tristis is a good indicator of weather lore for the prediction of both short- and long-range precipitation. The information about the prediction of rainfall by observing the flowering phenology was recorded through the interview with village elders. The researchers use interview schedule while interacting with elders. Several small groups of knowledge holders including elder men and women (as focus group) were selected randomly from a wider population of study areas and sampled. A questionnaire was also prepared for knowledge gathering through open conversation and discussion. Prior Informed Consent (PIC) was taken from the knowledge providers time to time.

Acharya S.,Tripura University
Indian Journal of Traditional Knowledge | Year: 2011

The method used by local and indigenous peoples for predicting rainfall and other weather conditions solely on the basis of bio-indicators - the phenology of plants and behavior of animals - is coined as a new term: Presage Biology. Some of these activities of floral and faunal diversity are described in their application to predict oncoming rain, based a literature review as well as personal observations of present author as well as other reference sources pertaining to India and different parts of the world.

Electronic spectrum of astrophysically important molecule magnesium hydride (MgH) has been studied using configuration interaction methodology excluding and including spin–orbit coupling. Potential energy curves of several spin-independent (Λ−S) electronic states have been constructed and spectroscopic constants of low-lying bound Λ−S states within 8.2 eV of term energy are reported in the first stage of calculations. The X2Σ+ is identified as the ground state in the Λ−S level. In the subsequent stage, the spin–orbit interaction has been incorporated and its effects on the potential energy curves and spectroscopic features of different electronic states of the species have been investigated. The X2Σ+ 1/2 is identified as the spin–orbit (Ω) ground state of the species. Transition moments of several dipole-allowed transitions are computed in both the stages and radiative lifetimes of the corresponding excited states are computed. Electric dipole moments (µ) for a number of low-lying bound Λ−S states as well as several low-lying Ω-states are also calculated in the present study. © 2016 Informa UK Limited, trading as Taylor & Francis Group

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