Tri Institutional Training Program in Computational Biology and Medicine and

Tri Institutional Training Program in Computational Biology and Medicine and

SEARCH FILTERS
Time filter
Source Type

PubMed | Applied Genomics, Sloan Kettering Cancer Center, University of Ulm, Huazhong University of Science and Technology and 3 more.
Type: Journal Article | Journal: Blood | Year: 2014

The survival of classical Hodgkin lymphoma (cHL) cells depends on activation of NF-B, JAK/STAT, and IRF4. Whereas these factors typically induce the master regulator of plasma cell (PC) differentiation PRDM1/BLIMP-1, levels of PRDM1 remain low in cHL. FOXO1, playing a critical role in normal B-cell development, acts as a tumor suppressor in cHL, but has never been associated with induction of PC differentiation. Here we show that FOXO1 directly upregulates the full-length isoform PRDM1 in cHL cell lines. We also observed a positive correlation between FOXO1 and PRDM1 expression levels in primary Hodgkin-Reed-Sternberg cells. Further, we show that PRDM1 acts as a tumor suppressor in cHL at least partially by blocking MYC. Here we provide a link between FOXO1 repression and PRDM1 downregulation in cHL and identify PRDM1 as a tumor suppressor in cHL. The data support a potential role for FOXO transcription factors in normal PC differentiation.

Loading Tri Institutional Training Program in Computational Biology and Medicine and collaborators
Loading Tri Institutional Training Program in Computational Biology and Medicine and collaborators