Tri Institutional Program on Computational Biology and Medicine CBM

New York, United States

Tri Institutional Program on Computational Biology and Medicine CBM

New York, United States

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Afshinnekoo E.,New York Medical College | Afshinnekoo E.,Queens College, City University of New York | Meydan C.,New York Medical College | Chowdhury S.,New York Medical College | And 50 more authors.
Cell Systems | Year: 2015

Afshinekoo et al respond to Ackelsberg et al. © 2015 Elsevier Inc.


Afshinnekoo E.,New York Medical College | Afshinnekoo E.,Queens College, City University of New York | Meydan C.,New York Medical College | Chowdhury S.,New York Medical College | And 51 more authors.
Cell Systems | Year: 2015

Summary The panoply of microorganisms and other species present in our environment influence human health and disease, especially in cities, but have not been profiled with metagenomics at a city-wide scale. We sequenced DNA from surfaces across the entire New York City (NYC) subway system, the Gowanus Canal, and public parks. Nearly half of the DNA (48%) does not match any known organism; identified organisms spanned 1,688 bacterial, viral, archaeal, and eukaryotic taxa, which were enriched for genera associated with skin (e.g., Acinetobacter). Predicted ancestry of human DNA left on subway surfaces can recapitulate U.S. Census demographic data, and bacterial signatures can match a station's history, such as marine-associated bacteria in a hurricane-flooded station. This baseline metagenomic map of NYC could help long-term disease surveillance, bioterrorism threat mitigation, and health management in the built environment of cities. © 2015 The Authors.

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