Tri-City Medical Center , founded in 1961, is a full-service, acute-care public hospital in Oceanside, California. Located 40 miles north of San Diego, Tri-City serves the three major cities in the North County section of San Diego County: Oceanside, Vista, and Carlsbad. The hospital also owns and operates nearby outpatient services, as well as the Tri-City Health and Wellness Complex in Carlsbad, home to the Tri-City Wellness Center, a 58,000-square-foot medically integrated training facility.TCMC is administered by the Tri-City Healthcare District, a Health District of California. Wikipedia.
Chung M.-T.,Tri-City Medical Center |
Lam K.-K.,Taipei Medical University
Journal of Cellular and Molecular Medicine | Year: 2017
Oestrogens have been reported to attenuate acute inflammation in sepsis. In this study, the effects of long-term oestrogen replacement with 17β-oestradiol (E2) on endotoxaemia-induced circulatory dysfunction and multiple organ dysfunction syndrome were evaluated in ovariectomized (Ovx) rats. E2 (50 μg/kg, s.c., 3 times/week) was administered for 8 weeks, followed by the induction of endotoxaemia by intravenous infusion of lipopolysaccharides (LPS; 30 mg/kg/4 hrs). Oestrogen deficiency induced by ovariectomy for 9 weeks augmented the LPS-induced damage, including endotoxic shock, myocardial contractile dysfunction, renal dysfunction and rhabdomyolysis. Cardiac levels of NF-κB p65, iNOS and oxidized glutathione, free radical production in skeletal muscles, myoglobin deposition in renal tubules, and plasma levels of plasminogen activator inhibitor-1, TNF-α, and IL-6 were more pronounced in the Ovx + LPS group than in the Sham + LPS group. Long-term treatment of E2 prevented this amplified damage in Ovx rats. Six hours after LPS initiation, activation of the autophagic process, demonstrated by increases in Atg12 and LC3B-II/LC3B-I ratios, and induction of haem oxygenase (HO)-1 and heat-shock protein (HSP) 70 protein expression in myocardium were increased significantly in the Ovx + E2 + LPS group. These results suggest that activation of autophagy and induction of HO-1 and HSP70 contribute to the protective effect of long-term E2 replacement on multiple organ dysfunction syndrome in endotoxaemia. © 2017 Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.
Dake M.D.,Stanford University |
Ansel G.M.,Riverside Methodist Hospital |
Jaff M.R.,Massachusetts General Hospital |
Ohki T.,Jikei University School of Medicine |
And 7 more authors.
Journal of the American College of Cardiology | Year: 2013
Objectives A prospective, multinational randomized controlled trial (RCT) and a complementary single-arm study evaluated the 2-year safety and effectiveness of a paclitaxel-coated drug-eluting stent (DES) in patients with superficial femoral artery lesions. The RCT compared the DES with percutaneous transluminal angioplasty (PTA) and provisional bare-metal stent (BMS) placement. Background Local drug delivery for superficial femoral artery lesions has been investigated with the intent of limiting restenosis similarly to DES for the coronary arteries. One-year outcomes of DES in the superficial femoral artery are promising, but longer-term benefits have not been established. Methods In the RCT, patients were randomly assigned to primary DES implantation (n = 236) or PTA (n = 238). Acute PTA failure occurred in 120 patients, who underwent secondary randomization to DES (n = 61) or BMS (n = 59) placement. The single-arm study enrolled 787 patients with DES treatment. Results Compared with the control group, the primary DES group demonstrated significantly superior 2-year event-free survival (86.6% vs. 77.9%, p = 0.02) and primary patency (74.8% vs. 26.5%, p < 0.01). In addition, the provisional DES group exhibited superior 2-year primary patency compared with the provisional BMS group (83.4% vs. 64.1%, p < 0.01) and achieved higher sustained clinical benefit (83.9% vs. 68.4%, p = 0.05). Two-year freedom from target lesion revascularization with primary DES placement was 80.5% in the single-arm study and 86.6% in the RCT. Conclusions Two-year outcomes with the paclitaxel-eluting stent support its sustained safety and effectiveness in patients with femoropopliteal artery disease, including the long-term superiority of the DES to PTA and to provisional BMS placement. (Evaluation of the Zilver PTX Drug-Eluting Stent in the Above-the-Knee Femoropopliteal Artery; NCT00120406; Zilver® PTX™ Global Registry; NCT01094678). © 2013 by the American College of Cardiology Foundation. Published by Elsevier Inc.
Chen S.-F.,China Medical University at Taichung |
Chen S.-F.,Department of National Defence |
Nieh S.,Department of National Defence |
Jao S.-W.,Tri Service General Hospital |
And 5 more authors.
Journal of Pathology | Year: 2013
Head and neck squamous cell carcinoma (HNSCC) is one of the leading causes of cancer-related death worldwide. The prognosis of HNSCC is usually poor because of its propensity for extensive invasion, local recurrence and frequent regional lymph node metastasis, even at initial diagnosis. Carcinoma-associated fibroblasts (CAFs), a major type of tumour-surrounding stromal cell, generate mediators through which they interact with tumours and contribute to cancer progression. The orchestration between CAFs and cancer cells is complex. Despite recent studies demonstrating the paracrine effect of stromal cells in the tumour microenvironment on initiation and progression of cancer cells, the major mediator related to CAFs and its underlying mechanism remain unknown. In the present study, we used organotypic culture to investigate CAFs that promote aggressive behaviour of HNSCC cells. Using microarray analysis, we detected abundant expression of interleukin-33 (IL-33) in CAFs and identified IL-33 as a critical mediator in CAF-induced invasiveness. Counteracting IL-33 activity diminished the aggressive phenotype of cancer cells induced by CAFs. Administration of IL-33 promoted cancer cell migration and invasion through induction of epithelial-to-mesenchymal transdifferentiation and increased IL-33 gene expression in cancer cells. In 40 patients with HNSCC, IL-33 expression in CAFs correlated with IL-33 expression in cancer cells. Most cases with a low invasion pattern grading score (IPGS) showed low or no expression of IL-33, whereas most HNSCC cases with high IPGS displayed over-expression of IL-33 in CAFs and cancer cells. High IL-33 expression associated with poor prognosis in terms of nodal metastasis-free survival. These results indicate that CAFs promote cancer invasiveness via paracrine and autocrine effects on microenvironmental IL-33 signalling, and suggest that IL-33 is a potential prognostic biomarker that could be considered in therapeutic strategies for the treatment of patients with HNSCC. Copyright © 2013 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. Copyright © 2013 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Kao H.-W.,University of California at Irvine |
Kao H.-W.,Tri-City Medical Center |
Tsai F.Y.,University of California at Irvine |
Tsai F.Y.,Taipei Medical University |
Hasso A.N.,University of California at Irvine
European Radiology | Year: 2012
Objectives To investigate the ability of susceptibilityweighted imaging (SWI) to predict stroke evolution in comparison with perfusion-weighted imaging (PWI). Methods In a retrospective analysis of 15 patients with nonlacunar ischaemic stroke studied no later than 24 h after symptom onset, we used the Alberta Stroke Program Early CT Score (ASPECTS) to compare lesions on initial diffusion-weighted images (DWI), SWI, PWI and followup studies obtained at least 5 days after symptom onset. The National Institutes of Health Stroke Scale scores at entry and stroke risk factors were documented. The clinical-DWI, SWI-DWI and PWI-DWI mismatches were calculated. Results SWI-DWI and mean transit time (MTT)-DWI mismatches were significantly associated with higher incidence of infarct growth (P00.007 and 0.028) and had similar ability to predict stroke evolution (P01.0). ASPECTS values on initial DWI, SWI and PWI were significantly correlated with those on follow-up studies (P≤0.026) but not associated with infarct growth. The SWI ASPECTS values were best correlated with MTT ones (00.8, P<0.001). Conclusions SWI is an alternative to PWI to assess penumbra and predict stroke evolution. Further prospective studies are needed to evaluate the role of SWI in guiding thrombolytic therapy. Key Points ̇ SWI can provide perfusion information comparable to MTT ̇ SWI-DWI mismatch can indicate ischaemic penumbra ̇ SWI-DWI mismatch can be a predictor for stroke evolutio. © European Society of Radiology 2012.
News Article | February 26, 2017
SAN DIEGO, CA, February 26, 2017 /24-7PressRelease/ -- Puzzle Pieces Marketing, LLC. is honored to be chosen by the Vista Chamber of Commerce to provide PR and Event Promotion Services at the 2017 Vista Strawberry Festival for the sixth year in a row. The Annual Vista Strawberry Festival is sponsored by the Tri-City Medical Center and is expected to draw more than 100,000 individuals to the festivities. The 2017 Strawberry Festival will officially begin with the Strawberry Festival Runs through Historic Downtown Vista at 6:45 AM on Sunday, May 28, 2017. " We are honored that the Vista Chamber of Commerce selected us as the PR agency for their annual Strawberry Festival. Puzzle Pieces Marketing is excited to promote and participate in this fun family event," said Angel Mason Broadus, President of Puzzle Pieces Marketing. The Vista Strawberry Festival is the Chamber's signature event of the year. It will be a day full of exciting activities, delicious food and endless fun. It is also a great opportunity to support the local Vista businesses. This year's Strawberry Festival will include countless contests, pie-eating, carnival rides, music, and much more! For more information, please visit the Strawberry Festival website at http://www.vistastrawberryfest.com. About Puzzle Pieces Marketing Puzzle Pieces Marketing, LLC. is a San Diego-based marketing and public relations firm offering comprehensive marketing services in the areas of Strategic Planning, Online Marketing, and Creative Design. Focusing on integrated marketing where every method works together across both traditional and non-traditional marketing channels, Puzzle Pieces Marketing uses a variety of marketing techniques to deliver measurable results. To learn more, visit PuzzlePiecesMarketing.com or contact them at (858) 848-6584. You can also find them on Facebook, Instagram, LinkedIn, Google+ and Twitter Contact: Puzzle Pieces Marketing Angel Mason Broadus email@example.com (858) 848-6584 http://www.PuzzlePiecesMarketing.com FOR IMMEDIATE RELEASE
Lin J.-G.,China Medical University at Taichung |
Chou P.-C.,China Medical University at Taichung |
Chu H.-Y.,Tri-City Medical Center
Evidence-based Complementary and Alternative Medicine | Year: 2013
Objective. To explore the existing scientific information regarding safe needling depth of acupuncture points and the needling depth of clinical efficacy. Methods. We searched the PubMed, EMBASE, Cochrane, Allied and Complementary Medicine (AMED), The National Center for Complementary and Alternative Medicine (NCCAM), and China National Knowledge Infrastructure (CNKI) databases to identify relevant monographs and related references from 1991 to 2013. Chinese journals and theses/dissertations were hand searched. Results. 47 studies were recruited and divided into 6 groups by measuring tools, that is, MRI, in vivo evaluation, CT, ultrasound, dissected specimen of cadavers, and another group with clinical efficacy. Each research was analyzed for study design, definition of safe depth, and factors that would affect the measured depths. Depths of clinical efficacy were discussed from the perspective of de-qi and other clinical observations. Conclusions. Great inconsistency in depth of each point measured from different subject groups and tools exists. The definition of safe depth should be established through standardization. There is also lack of researches to compare the clinical efficacy. A well-designed clinical trial selecting proper measuring tools to decide the actual and advisable needling depth for each point, to avoid adverse effects or complications and promote optimal clinical efficacy, is a top priority. © 2013 Jaung-Geng Lin et al.
Lawrence B.R.,Tri-City Medical Center |
Thuen E.,Tri-City Medical Center
Foot and Ankle Specialist | Year: 2013
Implant arthroplasty has been a surgical alternative for correction of hallux rigidus for many decades. A study is presented reviewing the authors' experience using the (Tornier/Futura) Primus double-stemmed silicone implant. A total of 144 patients representing 201 implants were identified and invited to participate in the study. The postoperative period ranged from 32 to 108 months, with an average of 66.4 months. Chart review was performed on all cases. This review revealed that there were 2 implants that had been removed, each for reasons other than implant breakdown. Several indications in addition to hallux rigidus were found, including hallux valgus with arthritis, geriatric bunion, rheumatoid arthritis, and iatrogenic and traumatic arthritis. The outcomes are presented for all patients, with additional breakdown by their indication for surgery. In all, 54 patients involving 70 implants responded and were clinically evaluated. This study included a Visual Analogue Scale, Foot and Ankle (VAS FA) patient outcome and satisfaction questionnaire, clinical examination, and X-ray evaluation. Patients with hallux rigidus had an average postoperative American Orthopaedic Foot and Ankle Society (AOFAS) score of 88.2, and those with hallux valgus with arthritis had an average score of 88.6. The average AOFAS score for all patients was 87.4. The average VAS patient satisfaction for all patients was 8.5 (with 10 being highest satisfaction). Implant arthroplasty continues to be a viable alternative for surgical correction of hallux rigidus as well as other degenerative conditions of the first MTP joint. This procedure is particularly effective in older, less-active patients with lower functional demand.Levels of Evidence: Therapeutic, Level IV, Retrospective case series © 2012 The Author(s).
Tai H.-Y.,Tamkang University |
Fu E.,Tri-City Medical Center |
Don T.-M.,Tamkang University
Carbohydrate Polymers | Year: 2012
Calcium deficient hydroxyapatite (CDHA) having an average particle size of 45 nm was synthesized by reverse emulsion method. It was converted to the respective biphasic calcium phosphate (BCP, 226 nm) and β-tricalcium phosphate (TCP, 450 nm) by calcination at 800°C and 1000°C, and the BCP consisted of 92% TCP and 8% CDHA. Subsequently, chitosan was mixed with calcium phosphates to prepare CDHA/chitosan, BCP/chitosan, and TCP/chitosan membranes. The initial moduli of the BCP/chitosan and TCP/chitosan membranes were about 1.9 times that of the pure chitosan membrane; and the elongations at break were almost 6 times. The CDHA/chitosan and BCP/chitosan could induce mineralization of apatite on the membranes by increasing 20.6 and 16.3 wt.%, respectively, after 24 days in the simulated body fluid. Moreover, the BCP/chitosan exhibited superior osteoblast cell attachment and proliferation than the other membranes. It has the potential to be used as the barrier membrane for guided bone regeneration. © 2012 Elsevier Ltd. All rights reserved.
Liston M.B.,Tri-City Medical Center
Journal of Hospital Librarianship | Year: 2012
Librarian involvement in the Magnet process is vital to an organization attempting to achieve the transformation required for accreditation. Magnet criteria for accreditation are in direct alignment with the Medical Library Association's recommendations for professional librarians to support evidence-based processes and decision-making within a health care environment. Specific criteria required of the New Knowledge, Innovations, and Improvements component of the Magnet process are described along with recommendations for librarian involvement. The framework outlined in this article is one method for librarians to facilitate organizational achievement of Magnet accreditation. © 2012 Copyright Taylor and Francis Group, LLC.