Trauson Medical Instrument Co.

Changzhou, China

Trauson Medical Instrument Co.

Changzhou, China

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Lin X.,CAS Shenyang Institute of Metal Research | Yang X.,Panyu Hospital of Chinese Medicine | Tan L.,CAS Shenyang Institute of Metal Research | Li M.,General Hospital of Guangzhou Military Command | And 5 more authors.
Applied Surface Science | Year: 2014

Magnesium alloys are promising biodegradable implant candidates for orthopedic application. In the present study, a phosphate-based micro-arc oxidation (MAO) coating was applied on the ZK60 alloy to decrease its initial degradation rate. Strontium (Sr) was incorporated into the coating in order to improve the bioactivity of the coating. The in vitro degradation studies showed that the MAO coating containing Sr owned a better initial corrosion resistance, which was mainly attributed to the superior inner barrier layer, and a better long-term protective ability, probably owning to its larger thickness, superior inner barrier layer and the superior apatite formation ability. The degradation of MAO coating was accompanied by the formation of degradation layer and Ca-P deposition layer. The in vitro cell tests demonstrated that the incorporation of Sr into the MAO coating enhanced both the proliferation of preosteoblast cells and the alkaline phosphatase activity of the murine bone marrow stromal cells. In conclusion, the MAO coating with Sr is a promising surface treatment for the biodegradable magnesium alloys. © 2013 Elsevier B.V. All rights reserved.


Tan L.-L.,CAS Shenyang Institute of Metal Research | Wang Q.,CAS Shenyang Institute of Metal Research | Wang Q.,Shenyang University | Geng F.,CAS Shenyang Institute of Metal Research | And 3 more authors.
Transactions of Nonferrous Metals Society of China (English Edition) | Year: 2010

A Ca-P coating consisting of biodegradable β-tricalcium phosphate [β-TCP, β-Ca3(PO4)2] accepted for medical application was coated on a biodegradable AZ31 alloy by chemical deposition to improve the corrosion resistance. The good bonding strength of the coating is obtained. The results show that the corrosion potential of the Ca-P coated AZ31 alloy increases significantly, and MG63 cells show good adherence, proliferation and differentiation on the surface of the coated alloy. The Ca-P coating might be an effective way to improve the surface bioactivity of magnesium alloys. © 2010 The Nonferrous Metals Society of China.


Wang Q.,CAS Shenyang Institute of Metal Research | Wang Q.,University of Chinese Academy of Sciences | Tan L.,CAS Shenyang Institute of Metal Research | Zhang Q.,General Hospital of the Peoples Liberation Army | And 2 more authors.
Biomedical Engineering - Applications, Basis and Communications | Year: 2011

Surface modification is believed to be an effective way to control the biodegradation rate of magnesium alloys and improve their biological properties. In the present work, a calcium phosphate (Ca-P) coating was prepared on the AZ31B magnesium alloy by a chemical deposition method to integrate the mechanical advantages of the magnesium substrate and the good bioactivity of the ceramic coating. It was shown that the coating was mainly composed of magnesium and calcium phosphates. Scanning electron microscope coupled with the energy dispersive spectrum analyses showed that rough and crystallined Ca-P coatings with different Ca/P ratios and thickness were formed on the alloy by variation of deposition time. The corrosion resistance of AZ31B alloy was significantly improved by the Ca-P coating. Electrochemical impedance spectroscopy test was used to illustrate the reaction process of Ca-P coating on the alloy. Upon the above results, Ca-P formation mechanism on the AZ31B alloy was proposed. The heterogeneous nucleation and growth of the calcium phosphate coating may be catalyzed by the anodic dissolution of the magnesium alloy substrate in the early stage of deposition, and the deposition coating is mainly composed of the magnesium phosphate. Then calcium phosphate deposition on the alloy becomes dominant with the increase of time. Tensile test in simulated body environment results showed that the time of fracture and ultimate tensile strength for the coated AZ31B Mg alloy were higher than those of the uncoated, which is beneficial in supporting fractured bone for a longer time. © 2011 National Taiwan University.


Lin X.,CAS Shenyang Institute of Metal Research | Tan L.,CAS Shenyang Institute of Metal Research | Zhang Q.,Chinese PLA General Hospital | Yang K.,CAS Shenyang Institute of Metal Research | And 3 more authors.
Acta Biomaterialia | Year: 2013

Magnesium has attracted much attention as a class of biodegradable metallic biomaterials. In this study, a silicate electrolyte-based micro-arc oxidation (MAO) treatment was adopted to prepare forsterite-containing MAO coatings on a ZK60 magnesium alloy in order to decrease the degradation rate and increase the biological property of the alloy. Four anodization voltages were chosen to prepare the MAO coatings. The cell experiment showed a cytotoxicity of grade 0 for the MAO-coated alloy to L929 cells and the hemolytic ratio was dramatically decreased for the MAO-coated alloy compared with the bare one. The corrosion resistance and the degradation behavior of the MAO-coated ZK60 alloy were studied using drop tests, electrochemical measurements and immersion tests. The results indicate that the MAO coating could effectively decrease the initial degradation rate of the alloy. The corrosion resistance of MAO coating was increased with the elevation of the preparation voltage. A degradation model for ZK60 alloy with a forsterite-containing MAO coating was proposed. Based on the model, the MAO-coated alloy experiences destruction and restoration simultaneously, and the coating fails in a peeling-off mode. © 2012 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

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