Shiraz Transplant Research Center

Shīrāz, Iran

Shiraz Transplant Research Center

Shīrāz, Iran
SEARCH FILTERS
Time filter
Source Type

PubMed | Gastroenterohepatology Research Center, Shiraz Transplant Research Center and Shiraz University of Medical Sciences
Type: Journal Article | Journal: International journal of organ transplantation medicine | Year: 2014

Liver transplantation (LT) is the standard treatment of end-stage liver diseases (ESLD). Invasive fungal infection is one of the important causes of morbidity and mortality after transplantation.To determine the incidence of late-onset (after 6 months of LT) Candida infection in recipients.A retrospective study was conducted to evaluate 50 pediatric patients after LT for 8 years at the LT Unit of Nemazee Hospital affiliated to Shiraz University of Medical Sciences, Shiraz, Iran. We followed the patients until 6 months post-LT for episodes of Candida infection proven by culture.One recipient (2%) developed late-onset esophageal candidiasis with improvement after intravenous amphotricin therapy but finally expired with a diagnosis of post-transplant lymphoproliferative disorder (PTLD).The incidence of late-onset Candida infection is not significant in pediatric liver recipient, but it still remains a significant problem. Control of Candida colonization would reduce the risk of invasive fungal infections and possibly more fatal complications.


PubMed | Gastroenterohepatology Research Center, Shiraz Transplant Research Center and Shiraz University of Medical Sciences
Type: Journal Article | Journal: International journal of organ transplantation medicine | Year: 2014

Liver transplantation (LT) is a life-saving treatment for end-stage liver diseases (ESLD). Cytomegalovirus (CMV) infection is one of the important causes of morbidity after LT.To evaluate the incidence of late-onset (after 6 months of LT) CMV infection in pediatric recipients.A retrospective analysis was conducted to evaluate 50 pediatric patients who underwent LT for 8 years at the LT Unit of Nemazee Hospital affiliated to Shiraz University of Medical Sciences, Shiraz, Iran. We retrospectively investigated episodes of CMV infection after 6 months of LT proven by CMV antigenemia test.Three recipients (6%) developed late-onset CMV infection. These patients finally responded to ganciclovir.CMV infection is one of the most common post-LT viral infections that usually occurs in the first six months of LT. Our study shows that the incidence of late-onset CMV infection is relatively low, but it still remains a significant problem. Therefore, monitoring and management is crucial for improving the survival of children.


Ebadi M.,Islamic Azad University at Science and Research of Fars | Yaghobi R.,Shiraz Transplant Research Center | Geramizadeh B.,Shiraz Transplant Research Center | Bahmani M.K.,Shiraz University of Medical Sciences | And 2 more authors.
Transplantation Proceedings | Year: 2011

Background: Infections with hepatitis C virus (HCV) and the familially related hepatitis G virus (HGV) threaten survival of liver transplant recipients. The prevalence and pathogenic effects of these hepatitis virus infections, in particular HGV, on clinical outcome and the need for surveillance are controversial. The present study examined the prevalence of HCV and HGV infections using polymerase chain reaction-based molecular methods in Iranian patients who had undergone orthotopic liver transplantation (oLT). Materials and Methods: Between 2007 and 2010, 202 EDTA-treated blood samples were obtained before and after liver transplantation in 106 patients. An optimized qualitative in-house multiplex reverse transcription polymerase chain reaction protocol was used for simultaneous diagnosis of HCV and HGV infections. Results: Hepatitis C virus molecular infection was diagnosed in 13 of 202 plasma samples (6.4%) in 10 of 106 patients (9.4%) before and after oLT. Eleven of 202 plasma samples (5.4%) from 10 of 106 patients (9.4%) demonstrated HGV genome infection before and after oLT. Conclusion: Detection of moderate prevalence of HCV and especially HGV infection in liver transplant recipients suggests potential importance of HCV infection in liver dysfunction and supports the hypothesis that HGV infection has a pathogenic role in liver-related clinical complications. © 2011 by Elsevier Inc. All rights reserved.


PubMed | Shiraz University of Medical Sciences and Shiraz Transplant Research Center
Type: Journal Article | Journal: International journal of organ transplantation medicine | Year: 2014

Solid organ transplantation is the only definitive treatment available for patients with end-stage organ failure. Organs procured from brain-death donors are the main source of transplants. Following brain death, a burst of inflammatory reaction develops; it is characterized by increased plasma levels of cytokines. This inflammatory reaction has been associated with increased early allograft dysfunction.In this study, we test if the increased inflammatory response in brain-death donors is associated with more recipient complications.We prospectively recruited 38 consecutive brain-death donors admitted to the intensive care units (ICUs) of Shiraz University of Medical Sciences. Following the declaration of brain death, the demographics data on donor and recipient characteristics and cause of brain death were recorded. The post-liver transplant complications in recipients were stratified according to the Clavien classification. Plasma levels of cytokines IL-6, IL-2, and TNF- were measured using enzyme linked immunosorbent assay (ELISA) kits, in all donors before organ procurement.The mean (range) age of donors was 44 (16-74) years. Trauma due to car accident was the most common cause of brain death (79%). The post-liver transplant complications occurred in 19 (50%) recipients. The meanSD plasma TNF- concentration was significantly (p<0.001) higher in recipients with grade 1-3 post-transplant complications (68.3327.74 pg/mL) than those without complication (22.094.14 pg/mL). Recipients with complications had also a significantly (p=0.001) higher meanSD donor plasma concentration of IL-6 (1009375.5 pg/mL) compared to those without complications (779202 pg/mL). No significant differences was observed between the two groups in respect to IL-2 concentration (0.2950.333 vs 0.2850.342 U/mL, p=0.207). Six recipients died of complications (grade5), in whom no correlation could be found with donor plasma cytokine concentrations.Higher plasma concentrations of IL-6 and TNF- in donors before organ procurement, are associated with more post-operative complications in liver transplant recipients.

Loading Shiraz Transplant Research Center collaborators
Loading Shiraz Transplant Research Center collaborators