Transonic Scisense Inc.

London, Canada

Transonic Scisense Inc.

London, Canada
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Kutty S.,University of Nebraska Medical Center | Kottam A.T.,Transonic Scisense Inc. | Padiyath A.,University of Nebraska Medical Center | Bidasee K.R.,University of Nebraska Medical Center | And 6 more authors.
Experimental Physiology | Year: 2013

The admittance and Wei's equation is a new technique for ventricular volumetry to determine pressure-volume relations that addresses traditional conductance-related issues of parallel conductance and field correction factor. These issues with conductance have prevented researchers from obtaining real-time absolute ventricular volumes. Moreover, the time-consuming steps involved in processing conductance catheter data warrant the need for a better catheter-based technique for ventricular volumetry. We aimed to compare the accuracy of left ventricular (LV) volumetry between the new admittance catheterization technique and transoesophageal real-time three-dimensional echocardiography (RT3DE) in a large-animal model. Eight anaesthetized pigs were used. A 7 French admittance catheter was positioned in the LV via the right carotid artery. The catheter was connected to an admittance control unit (ADVantage; Transonic Scisense Inc.), and data were recorded on a four-channel acquisition system (FA404; iWorx Systems). Admittance catheterization data and transoesophageal RT3DE (X7-2; Philips) data were simultaneously obtained with the animal ventilated, under neuromuscular blockade and monitored in baseline conditions and during dobutamine infusion. Left ventricular volumes measured from admittance catheterization (Labscribe; iWorx Systems) and RT3DE (Qlab; Philips) were compared. In a subset of four animals, admittance volumes were compared with those obtained from traditional conductance catheterization (MPVS Ultra; Millar Instruments). Of 37 sets of measurements compared, admittance- and RT3DE-derived LV volumes and ejection fractions at baseline and in the presence of dobutamine exhibited general agreement, with mean percentage intermethod differences of 10% for end-diastolic volumes, 14% for end-systolic volumes and 9% for ejection fraction; the respective intermethod differences between admittance and conductance in eight data sets compared were 11, 11 and 12%. Admittance volumes were generally higher than those obtained by RT3DE, especially among the larger ventricles. It is concluded that it is feasible to derive pressure-volume relations using admittance catheterization in large animals. This study demonstrated agreements between admittance and RT3DE to within 10-14% mean intermethod difference in the estimation of LV volumes. Further investigation will be required to examine the accuracy of volumes in largest ventricles, where intermethod divergence is greatest. © 2013 The Authors. Experimental Physiology © 2013 The Physiological Society.


Fricke K.,University of Western Ontario | Konecny F.,Transonic Scisense Inc. | El-Warrak A.,University of Western Ontario | Hodgson C.,Transonic Scisense Inc. | And 4 more authors.
Biomedical Microdevices | Year: 2016

We present in-vivo study related to the use of our implantable RF telemetry system for pressure-volume (PV) cardiac monitoring in a animal subject. We implant a commercial MEMS PV sensor into the subject’s heart left-ventricle (LV), while the telemetry system is implanted outside of the heart and connected to the sensor with a 7-microwires tether. The RF telemetry system is suitable for commercial application in medium sized subjects, its total volume of 2.475cm3 and a weight of 4.0g. Our designed system is 58 % smaller in volume, 44 % in weight and has a 55 % reduction in sampling power over the last reported research in PV telemetry. In-vivo data was captured in both an acute and a freely moving setting over a 24 hour period. We experimentally demonstrated viability of the methodology that includes the surgical procedure and real-time monitoring of the in-vivo data in a freely moving subject. Further improvements in catheter design will improve the data quality and safety of the subject. This real–time implantable technology allows for researchers to quantify cardiac pathologies by extracting real–time pressure-volume loops, wirelessly from within freely moving subjects. © 2016, Springer Science+Business Media New York.


Fricke K.,University of Western Ontario | Konecny F.,Transonic Scisense Inc. | El-Warrak A.,University of Western Ontario | Hodgson C.,Transonic Scisense Inc. | And 4 more authors.
IEEE Biomedical Circuits and Systems Conference: Engineering for Healthy Minds and Able Bodies, BioCAS 2015 - Proceedings | Year: 2015

We present our in-vivo study related to the use of our implantable RF telemetry system for pressure-volume (PV) cardiac monitoring in animal subject. We used commercial MEMS PV sensor that is implanted into the subject's heart left-ventricle (LV), while the telemetry was implanted close-by and connected to the sensor with a 7-microwires tether. The study demonstrated viability of the methodology that includes the surgical procedure and real-Time monitoring of the in-vivo data in a freely moving subject. © 2015 IEEE.


Popa S.,University of Western Ontario | Popa S.,Imperial College London | Fricke K.,University of Western Ontario | Dubois J.,Transonic Scisense Inc. | And 2 more authors.
IEEE Transactions on Biomedical Engineering | Year: 2014

A full set of finite-element method (FEM) studies of the catheter within a cylindrical cuvette and within an elliptical cuvette are presented along with novel insight on the fundamental electromagnetic properties of the catheter. An in vitro experiment with modified small mouse pressure-volume catheters was conducted and the results are presented as a validation of the FEM models. In addition, sensitivity analysis on the electrode size and position is conducted and the results allow for a novel calibration factor based on catheter geometry to be presented. This calibration factor is used in conjunction with Wei's conductance volume equations to reduce the average measured error in cuvette volume measurements from 26.5% to 5%. © 2014 IEEE.


Fricke K.,University of Western Ontario | Sobot R.,University of Western Ontario | Hodgson C.,Transonic Scisense Inc.
IEEE 2014 Biomedical Circuits and Systems Conference, BioCAS 2014 - Proceedings | Year: 2014

We present our design and submersion evaluation of a custom bio-compatible implant capsule to house our wireless telemetry system for cardiac monitoring. The package is 3D printed in two sizes and four different materials: ABS, bio-compatible ABS-M30i, RDG720 Transparent Acrylic, and 316L Stainless Steel. A long-term 98 day and 1 week short-term water immersion study is performed to validate the design and encapsulation process. Each implant is sealed with Loctite 4311 epoxy and dipped into Loctite 5091 silicone to create an impermeable membrane. Conclusion of the long-term immersion study determined the implant capsule suitable for in-vivo studies. © 2014 IEEE.


PubMed | University of Western Ontario and Transonic Scisense Inc.
Type: Journal Article | Journal: Biomedical microdevices | Year: 2016

We present in-vivo study related to the use of our implantable RF telemetry system for pressure-volume (PV) cardiac monitoring in a animal subject. We implant a commercial MEMS PV sensor into the subjects heart left-ventricle (LV), while the telemetry system is implanted outside of the heart and connected to the sensor with a 7-microwires tether. The RF telemetry system is suitable for commercial application in medium sized subjects, its total volume of 2.475cm(3) and a weight of 4.0g. Our designed system is 58 % smaller in volume, 44 % in weight and has a 55 % reduction in sampling power over the last reported research in PV telemetry. In-vivo data was captured in both an acute and a freely moving setting over a 24 hour period. We experimentally demonstrated viability of the methodology that includes the surgical procedure and real-time monitoring of the in-vivo data in a freely moving subject. Further improvements in catheter design will improve the data quality and safety of the subject. This real-time implantable technology allows for researchers to quantify cardiac pathologies by extracting real-time pressure-volume loops, wirelessly from within freely moving subjects.


Patent
Transonic Scisense Inc. | Date: 2014-02-24

A sensor package for a microelectromechanical system (MEMS) is provided. The sensor package comprises a slot for receiving a MEMS, a bonding area in, or adjacent to, the slot for bonding the MEMS to the package and at least one package electrode to engage an electrode pad on the MEMS. Each package electrode is in communication with a conductor pad for connecting the MEMS to an electronic device.


A method for real-time observation of absolute ventricular volume wherein electrical measurements are made with a tetra polar catheter and compared to electrical measurements in a database, said database being assembled using electric field theory to predict the non-linear relation between blood volume and electrical measurements between a fist limit characterized by an infinitely thick volume of blood and second limit characterized by infinitely thick tissue completely surrounding the catheter. The calculations are performed under the assumption that the blood is surrounded by an infinitely thick region of tissue.

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