Translational Genomic Science Institute

Phoenix, AZ, United States

Translational Genomic Science Institute

Phoenix, AZ, United States
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Dumitrescu L.,Vanderbilt University | Carty C.L.,Fred Hutchinson Cancer Research Center | Franceschini N.,University of North Carolina at Chapel Hill | Hindorff L.A.,National Human Genome Research Institute | And 26 more authors.
Human Genetics | Year: 2013

Genome-wide association studies (GWAS) have identified many variants that influence high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and/or triglycerides. However, environmental modifiers, such as smoking, of these known genotype-phenotype associations are just recently emerging in the literature. We have tested for interactions between smoking and 49 GWAS-identified variants in over 41,000 racially/ethnically diverse samples with lipid levels from the Population Architecture Using Genomics and Epidemiology (PAGE) study. Despite their biological plausibility, we were unable to detect significant SNP × smoking interactions. © 2013 Springer-Verlag Berlin Heidelberg.

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