Kumar K.S.,Osmania University |
Meesa S.R.,Osmania University |
Rajesham B.,Osmania University |
Bhasker B.,Osmania University |
And 4 more authors.
RSC Advances | Year: 2016
An inexpensive, practical and one-pot method has been developed for the synthesis of quinoxalines fused with pyrano[3,4-b]indole, the central core of Lamellarin D. The methodology involved construction of the central pyranone ring via an AlCl3-mediated heteroarylation-cyclization method. A number of compounds were prepared using this methodology, some of which were converted to the corresponding indol-3-ylquinoxaline derivatives. Several of the pyrano[3,4-b]indole fused quinoxalines showed promising growth inhibition of cervical and lung cancer cells and good interactions with topoisomerase I in silico. © The Royal Society of Chemistry.