Central Laboratory for Stem Cell Research and Translational Medicine

Hyderabad, India

Central Laboratory for Stem Cell Research and Translational Medicine

Hyderabad, India
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Kumar K.S.,Osmania University | Meesa S.R.,Osmania University | Rajesham B.,Osmania University | Bhasker B.,Osmania University | And 4 more authors.
RSC Advances | Year: 2016

An inexpensive, practical and one-pot method has been developed for the synthesis of quinoxalines fused with pyrano[3,4-b]indole, the central core of Lamellarin D. The methodology involved construction of the central pyranone ring via an AlCl3-mediated heteroarylation-cyclization method. A number of compounds were prepared using this methodology, some of which were converted to the corresponding indol-3-ylquinoxaline derivatives. Several of the pyrano[3,4-b]indole fused quinoxalines showed promising growth inhibition of cervical and lung cancer cells and good interactions with topoisomerase I in silico. © The Royal Society of Chemistry.

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