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Garg A.,Translam Institute of Pharmaceutical Education and Research | Singh R.,Mm University
International Journal of Phytomedicine | Year: 2014

Obesity is a chronic disorder of global prevalence and associated with morbidity and mortality. Therefore, attention is being focused on the investigation of plant-based drugs used in the traditional medicine for the treatment of obesity. The presents work evaluates the anti-lipase and antiobesity activity of ethanol and aqueous extracts of Enccostemma ltttorale (ElEe & ElAe) (Genitanaceae) (Synonym - Enicostemma axillare) in HFD induced obesity in rats. Male Wistar rats weighing 150200 g were divided into different group’s i.e. Normal control, HFD control, Orlistat (lipase inhibitor), ElEe & ElAe at doses of 200, 400, 250 and 500 mg/kg p.o. Treatment was started after 6 weeks upto 12 weeks alongwith HFD (except normal control). Oxidative stress was measured by measuring MDA, SOD and GSH level. Obesity was assessed by measuring morphological parameters, serum glucose, serum cholesterol, triglycerides and HDL level. ElEe & ElAe at 200, 400, 250 and 500 mg/kg/orally significantly attenuated morphological parameters i.e. weight gain, BMI, WHR, obesity index and adiposity index respectively as compare to HFD control group. Similarly, serum glucose, triglyceride, total cholesterol and oxidative stress were found to be attenuated as compare to HFD control group. The aqueous and ethanol extracts of Enicostemma littorale exhibit significant anti-lipase and antiobesity activity in high fat diet induced obesity in rats. © 2014, Advanced Research Journals. All rights reserved.

Kumar R.,Meerut Institute of Engineering and Technology | Subramanian A.,Institute of Physics, Bhubaneswar | Masand N.,L L R M Medical College | Patil V.M.,Translam Institute of Pharmaceutical Education and Research
Digest Journal of Nanomaterials and Biostructures | Year: 2010

Docking studies into the catalytic sites of COX-2 inhibitor were used to identify potential lead COX-2 inhibitor compounds. Those derivatives with good binding energies were chosen for synthesis and biological evaluation was done to support docking results with practical data. Compound P1, P2 and P3 endowed with best binding energy (-5.72, -5.71 and -5.82 kcal/mol respectively) in docking studies with COX-2 receptor. For analgesic evaluation acetic acid induced writhing method and hot plate method were used. The results indicate that three compounds (P1, P2 and P3) possess the analgesic activity at ≥47.5 mg/kg dose level.

Tiwari B.K.,Translam Institute of Pharmaceutical Education and Research | Khosa R.L.,Bharat Institute of Technology
Internet Journal of Tropical Medicine | Year: 2010

The flower heads of Sphaeranthus indicus Linn (Asteraceae) a traditional Indian medicinal plant is commonly used to nourish and improve the liver conditions. This study was designed to evaluate the hepatoprotective and antioxidant effect of aqueous (AQS) and methanolic (MES) extract of flower heads of Sphaeranthus indicus on Paracetamol (APAP)-induced hepatotoxicity in rat's in-vivo. Activities of liver marker enzymes, glutamate-oxaloacetate transaminase (SGOT) glutamate pyruvate transaminase (SGPT), acid phosphatase (ACP) and alkaline phosphatase (ALP) bilirubin and total protein at an oral dose of MES (300mg/kg) showed a significant hepatoprotective effect in comparison with the same dose of aqueous extract. This fact was also confirmed by studying the liver histopathology of treated animals. As Regards the antioxidant activity, MES exhibited a significant effect (P < 0.05) showing increasing levels of superoxide dismutase (SOD), Catalase (CAT), and glutathione peroxides (GPX) by reducing malondialdehyde (MDA) levels. © Internet Scientific Publications, LLC., 1996 to 2010.

Kaur P.,Lovely Professional University | Kumar N.,Translam Institute of Pharmaceutical Education and Research | Shivananda T.N.,Indian Institute of Horticulturural Research | Kaur G.,Lovely Professional University
Journal of Medicinal Plant Research | Year: 2011

Mimosa pudica is the herb that shows sensation on touch. It has been identified as Lajjalu in Ayurveda and has been found to have antiasthmatic, aphrodisiac, analgesic, anti-inflammatory and antidepressant activities. In the present study the active phytocomponents of M. pudica were revealed using phytochemical analysis. The antimicrobial activity of Mimosa was studied using disk diffusion method. The activity was tested against Straphyloccus aureus, Escherichia coli, Pseudomonas aeruginosa and Candida albicans at different concentrations of 25, 30 and 35 mg/ml and the results have been illustrated. © 2011 Academic Journals.

Chaudhary R.,Translam Institute of Pharmaceutical Education and Research | Shuaib M.,Kalka Institute of Research and Advanced Studies | Hashim S.R.,Indian Institute of Chemical Technology | Mishra P.S.,Meerut Institute of Engineering and Technology
Asian Journal of Chemistry | Year: 2016

Cinnamoyl ureas have been identified as novel compounds with their various biological activities. Some novel cinnamoyl ureas were synthesized successfully by these substitutions, at the phenyl ring, at α,β -unsaturated carbon and the substitution at the carbonyl functionality, which further were studied for their antitumor activity. Thus in this research work, we aimed to use all these active moieties with phenyl urea substitutions at carbonyl moiety. Molecular docking study was used for confirming their interaction with tubulin protein for their antitumor activity. Through in silico molecular docking study, the result showed that all the synthesized compounds (3a-3e) have minimum binding energy and good affinity toward their active pocket, thus they were considered as good antitumor agents.

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