Translam Institute of Pharmaceutical Education and Research

Meerut, India

Translam Institute of Pharmaceutical Education and Research

Meerut, India

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Kumar R.,Meerut Institute of Engineering and Technology | Subramanian A.,Institute of Physics, Bhubaneswar | Masand N.,L L R M Medical College | Patil V.M.,Translam Institute of Pharmaceutical Education and Research
Digest Journal of Nanomaterials and Biostructures | Year: 2010

Docking studies into the catalytic sites of COX-2 inhibitor were used to identify potential lead COX-2 inhibitor compounds. Those derivatives with good binding energies were chosen for synthesis and biological evaluation was done to support docking results with practical data. Compound P1, P2 and P3 endowed with best binding energy (-5.72, -5.71 and -5.82 kcal/mol respectively) in docking studies with COX-2 receptor. For analgesic evaluation acetic acid induced writhing method and hot plate method were used. The results indicate that three compounds (P1, P2 and P3) possess the analgesic activity at ≥47.5 mg/kg dose level.


Chaudhary R.,Translam Institute of Pharmaceutical Education and Research | Shuaib M.,Kalka Institute of Research and Advanced Studies | Hashim S.R.,Indian Institute of Chemical Technology | Mishra P.S.,Meerut Institute of Engineering and Technology
Asian Journal of Chemistry | Year: 2016

Cinnamoyl ureas have been identified as novel compounds with their various biological activities. Some novel cinnamoyl ureas were synthesized successfully by these substitutions, at the phenyl ring, at α,β -unsaturated carbon and the substitution at the carbonyl functionality, which further were studied for their antitumor activity. Thus in this research work, we aimed to use all these active moieties with phenyl urea substitutions at carbonyl moiety. Molecular docking study was used for confirming their interaction with tubulin protein for their antitumor activity. Through in silico molecular docking study, the result showed that all the synthesized compounds (3a-3e) have minimum binding energy and good affinity toward their active pocket, thus they were considered as good antitumor agents.


Chaudhary R.,Translam Institute of Pharmaceutical Education and Research | Shuaib,K.I.R.A.S | Riaz Hashim S.,Indian Institute of Chemical Technology | Mishra P.S.,M.I.E.T
Der Pharma Chemica | Year: 2015

Substituted cinnamoyl ureas have been identified as novel compounds with their various biological activities. The novel cinnamoyl ureas were synthesized successfully by various substitutions, at the various position, which further were evaluated for their tubulin inhibitor activity.Thus in this research work, we aimed to use all these active moieties with urea and phenyl urea substitutions at carbonyl moiety. Molecular docking study was used for confirming their interaction with tubulin protein taking MSE137, ACO 201 and MSE148 as tubulin molecule for their antitumor activity. Through molecular docking study, the result showed that all the synthesized compounds act by inhibiting cell mitosis by binding to the protein tubulin in the mitotic spindle and preventing polymerization or depolymerization into the microtubules. Among the synthesized compounds 3a,3b, 3d showed higher no of interaction with amino acids of tubulin molecule, thus they were considered as good antitumor agents.


Chaudhary A.K.,Uttarakhand Technical University | Chaudhary A.K.,Subharti University | Ahmad S.,Translam Institute of Pharmaceutical Education and Research | Mazumder A.,Noida Institute of Engineering and Technology
Journal of Natural Medicines | Year: 2014

Cedrus deodara and Pinus roxburghii, plants mentioned in Indian literature, have been described to possess central nervous system effects and are used in Ayurvedic medicine to treat disorders of the mind. To investigate the memory-enhancing activity of volatile oil and chloroform extracts of C. deodara and P. roxburghii in the Morris water maze paradigm as well as evaluating their antioxidant properties. Aged albino mice were used to study the effect of oil and chloroform extracts on learning and memory by using the Morris water maze paradigm. The chloroform extract of C. deodara produced a significant decrease in escape latency over 7 days of training in both reference and working memory training in comparison to the control group. In the probe trial on day 8, mice in the chloroform extract of C. deodara group crossed the target area more often and spent more time in the target quadrant. Amongst the oils and extracts tested for oxidative stress parameters, only the chloroform extract of C. deodara at doses of 100 mg/kg produced a significant decrease in malondialdehyde (MDA) with a simultaneous significant increase in the level of glutathione (GSH) in both the frontal cortex and hippocampus. The present findings indicate that the chloroform extract of C. deodara has the best memory-enhancing effect due to its strong antioxidant properties from compounds like terpenoids and flavonoids. The study provides a scientific rationale for the traditional use of C. deodara in the management of memory dysfunction and related disorders. © 2013 The Japanese Society of Pharmacognosy and Springer Japan.


Garg A.,Translam Institute of Pharmaceutical Education and Research | Singh R.,Mm University
International Journal of Phytomedicine | Year: 2014

Obesity is a chronic disorder of global prevalence and associated with morbidity and mortality. Therefore, attention is being focused on the investigation of plant-based drugs used in the traditional medicine for the treatment of obesity. The presents work evaluates the anti-lipase and antiobesity activity of ethanol and aqueous extracts of Enccostemma ltttorale (ElEe & ElAe) (Genitanaceae) (Synonym - Enicostemma axillare) in HFD induced obesity in rats. Male Wistar rats weighing 150200 g were divided into different group’s i.e. Normal control, HFD control, Orlistat (lipase inhibitor), ElEe & ElAe at doses of 200, 400, 250 and 500 mg/kg p.o. Treatment was started after 6 weeks upto 12 weeks alongwith HFD (except normal control). Oxidative stress was measured by measuring MDA, SOD and GSH level. Obesity was assessed by measuring morphological parameters, serum glucose, serum cholesterol, triglycerides and HDL level. ElEe & ElAe at 200, 400, 250 and 500 mg/kg/orally significantly attenuated morphological parameters i.e. weight gain, BMI, WHR, obesity index and adiposity index respectively as compare to HFD control group. Similarly, serum glucose, triglyceride, total cholesterol and oxidative stress were found to be attenuated as compare to HFD control group. The aqueous and ethanol extracts of Enicostemma littorale exhibit significant anti-lipase and antiobesity activity in high fat diet induced obesity in rats. © 2014, Advanced Research Journals. All rights reserved.


Alam M.S.,Jazan University | Ali M.S.,Jazan University | Alam N.,Jazan University | Alam M.I.,Jazan University | And 5 more authors.
Journal of Applied Pharmaceutical Science | Year: 2012

Psoriasis is a chronic T lymphocyte mediated autoimmune inflammatory disorder that affects the skin, joints, and tendons. Betamethasone dipropionate (BD) has anti-inflammatory, immunosuppressive,and antiproliferative activity. The aim of this study was to investigate and evaluate a nanoemulsion topical gel of betamethasone dipropionate. For the preparation of nanoemulsion eucalyptus oil and babchi oil was taken. Nanomulsions were prepared by aqueous phase-titration method. Pseudoternary phase diagrams were constructed for the identification of nanoemulsion existence zones. Prepared nanoemulsions were subjected to different thermodynamic stability tests and characterized for droplet size, viscosity and refractive index. In vitro skin permeation of betamethasone dipropionate through rat abdominal skin was determined by the Franz diffusion cell. The prepared nanoemulsion gel is a potential vehicle for improved topical delivery of BD for better treatment of psoriasis.


Kaur P.,Lovely Professional University | Kumar N.,Translam Institute of Pharmaceutical Education and Research | Shivananda T.N.,Indian Institute of Horticulturural Research | Kaur G.,Lovely Professional University
Journal of Medicinal Plant Research | Year: 2011

Mimosa pudica is the herb that shows sensation on touch. It has been identified as Lajjalu in Ayurveda and has been found to have antiasthmatic, aphrodisiac, analgesic, anti-inflammatory and antidepressant activities. In the present study the active phytocomponents of M. pudica were revealed using phytochemical analysis. The antimicrobial activity of Mimosa was studied using disk diffusion method. The activity was tested against Straphyloccus aureus, Escherichia coli, Pseudomonas aeruginosa and Candida albicans at different concentrations of 25, 30 and 35 mg/ml and the results have been illustrated. © 2011 Academic Journals.


Chaudhary P.,Translam Institute of Pharmaceutical Education and Research | Ahmad S.,Translam Institute of Pharmaceutical Education and Research | Khan N.A.,IFTM University
Asian Journal of Pharmaceutical and Clinical Research | Year: 2016

Liver diseases have become one of the major causes of morbidity and mortality all over the world. From among, drug-induced liver injury is one of the most common causative factors that possess a major clinical and regulatory challenge. Herbal plants have been used traditionally by herbalist worldwide for the prevention and treatment of liver disease. Herbal medicines have recently attracted much attention as alternative medicines useful for treating or preventing lifestyle related disorders and relatively very little knowledge is available about their mode of action. There has been a growing interest in the analysis of plant products which has stimulated intense research on their potential health benefits. Allopathic drugs cause toxicity to the liver by elevating the levels of various biomarkers present in the liver. At present, no single allopathic drug is available in the market for liver damage. Only Liv.52 and silymarin are herbal medicine for this purpose, so herbal drugs have a strong potential in the treatment of liver diseases. The herbal market, in the recent times, is growing day by day and is accepted at the global level. The present review focused on different herbal plants that have been tested for hepatotoxicity in different animal models. © 2016, Asian Journal of Pharmaceutical and Clinical Research. All rights reserved.


Tiwari B.K.,Translam Institute of Pharmaceutical Education and Research | Khosa R.L.,Bharat Institute of Technology
Internet Journal of Tropical Medicine | Year: 2010

The flower heads of Sphaeranthus indicus Linn (Asteraceae) a traditional Indian medicinal plant is commonly used to nourish and improve the liver conditions. This study was designed to evaluate the hepatoprotective and antioxidant effect of aqueous (AQS) and methanolic (MES) extract of flower heads of Sphaeranthus indicus on Paracetamol (APAP)-induced hepatotoxicity in rat's in-vivo. Activities of liver marker enzymes, glutamate-oxaloacetate transaminase (SGOT) glutamate pyruvate transaminase (SGPT), acid phosphatase (ACP) and alkaline phosphatase (ALP) bilirubin and total protein at an oral dose of MES (300mg/kg) showed a significant hepatoprotective effect in comparison with the same dose of aqueous extract. This fact was also confirmed by studying the liver histopathology of treated animals. As Regards the antioxidant activity, MES exhibited a significant effect (P < 0.05) showing increasing levels of superoxide dismutase (SOD), Catalase (CAT), and glutathione peroxides (GPX) by reducing malondialdehyde (MDA) levels. © Internet Scientific Publications, LLC., 1996 to 2010.


Ali F.,Translam Institute of Pharmaceutical Education and Research
International Journal of Pharma and Bio Sciences | Year: 2015

A simple, precise, sensitive and rapid reverse phase high performance liquid chromatographic method was developed for the estimation of Pantoprazole in bulk and pharmaceutical dosage forms. The method was developed by using Waters X-Bridge C- 18(4.6×150 mm, 5μm) column; mobile phase consisting of ACN and bicarbonate buffer at pH 9.0; the flow rate of 1.0 ml/min and detection wavelength 214nm and eluted at 4.775 min. The linearity ranges were 25 to 125ppm for Pantoprazole. The method was validated as per ICH guidelines for various parameters like linearity, precision, accuracy, LOD, LOQ and robustness. The validated method was applied to the commercially available pharmaceutical dosage forms and obtained the desired result.

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