Translam Institute of Pharmaceutical Education and Research

Meerut, India

Translam Institute of Pharmaceutical Education and Research

Meerut, India
SEARCH FILTERS
Time filter
Source Type

Chaudhary A.K.,Uttarakhand Technical University | Chaudhary A.K.,Subharti University | Ahmad S.,Translam Institute of Pharmaceutical Education and Research | Mazumder A.,Noida Institute of Engineering and Technology
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2014

Objective: To evaluate the antiulcer activity of chloroform extract of Cedrus deodara and Pinus roxburghii wood (Cd C and Pr C, respectively). Methods: Cd C and Pr C at doses of 50 and 100 mg/kg were given orally to fasted rats and ulcers were induced by pyloric ligation and ethanol. Number of ulcer, ulcer score, ulcer index, percentage ulcer inhibition and tissue histology were measured in both the models. The effect on volume of gastric secretion, pH, total acidity and free acidity were evaluated in the pyloric ligation model. Results: Cd C (50, 100 mg/kg) and Pr C (50, 100 mg/kg) extracts were able to protect gastric mucosa against pyloric ligation and ethanol. In case of pyloric ligation model respective inhibition produced were 24.18, 60.44, 10.98 and 25.27%, and in case of ethanol model inhibition were 30.00, 56.36, 20.91 and 29.09%. Like famotidine, Cd C 100 significantly decreased the gastric content (2.40 ± 0.313 to 2.09 ± 0.095 ml), total acidity (473.85 ± 25.774 to 246.04 ± 32.602 meq./l) and free acidity (357.21 ± 30.496 to 182.25 ± 25.774 meq./l) and increase the pH of gastric content (2.99 ± 0.097 to 3.68 ± 0.221) in pyloric ligation model. The protective effect of this extract was associated with marked reduction in gastric hemorrhage and maintenance of tissue integrity. Conclusion: The present investigation provides the rationale for the use of Cedrus deodara in the management of peptic ulcer.


Garg A.,Translam Institute of Pharmaceutical Education and Research | Singh R.,Mm University
International Journal of Pharmaceutical Sciences Review and Research | Year: 2015

Obesity is a chronic disorder of global prevalence and associated with morbidity and mortality. The presents work evaluates the effect of ethanol (AmEe) and aqueous (AmAe) extracts of Aegle marmelos leaves in high fat diet (HFD) induced obese rats. Male Wistar rats weighing 150-200 g were divided into different groups i.e. Normal control, HFD control, Orlistat (lipase inhibitor), AmEe and AmAe at doses of 200, 400, 250 and 500 mg/kg. Treatment was started after 6 weeks upto 12 weeks along with HFD (except normal control). Oxidative stress was measured by measuring MDA, SOD and GSH level. AmEe and AmAe at 200, 400, 250 and 500 mg/kg/orally significantly attenuated oxidative stress as well as morphological parameters i.e. % body weight gain, BMI, WHR, obesity index, adiposity index respectively as compare to HFD control group. Similarly, serum glucose, triglyceride and total cholesterol were found to be attenuated as compare to HFD control group. Thus AmEe and AmAe exhibited antiobesity activity may due to decrease fat pad mass, by reduced adipocyte differentiation or by decreasing adipocyte hypertrophy in high fat diet induced obese rats. © 2015, Global Research Online. All rights reserved.


Khan I.,Shobhit University | Singh V.,Translam Institute of Pharmaceutical Education and Research | Chaudhary A.K.,Subharti University
Bangladesh Journal of Pharmacology | Year: 2012

The hepatoprotective activity of wood oil of Pinus roxburghii at doses of 200, 300 and 400 mg/kg body weight were studied on rat liver damage induced by CCL4 and ethanol. The substantially elevated serum enzymatic levels of SGPT, SGOT, ALP, total bilirubin, MDA and decreased level of GSH and total protein induced by hepatotoxins were significantly restored towards normalization by the wood oil at doses of 200 and 300 mg/kg. Hepatoprotective effect of oil may be due to its inhibitory effect on free radical formation as evident by recovery of GSH contents and decreased lipid peroxidation. Light microscopy of the liver tissue further confirmed the reversal of damage induced by hepatotoxins. Phytochemical analysis revealed presence of triterpenes and steroids, which have been known for their hepatoprotective activity. The results indicate that this plant possess hepatoprotective property that support the reported therapeutic use of plant in Indian system of medicine.


Kumar A.,Shobhit University | Singh V.,Translam Institute of Pharmaceutical Education and Research | Chaudhary A.K.,Shobhit University
Journal of Ethnopharmacology | Year: 2011

Ethnopharmacological relevance: Cedrus deodara (Roxb.) Loud. is used in Ayurvedic medicine to treat peptic ulcer. Aim of the study: To evaluate the gastric antisecretory and antiulcer activity of Cedrus deodara. Materials and methods: The volatile oil extracted by steam distillation of Cedrus deodara wood was examined for its gastric antisecretory and antiulcer effect in the pylorus-ligated rat model and ethanol induced gastric lesions in rats. Results: The volatile oil showed significant antisecretory activity as evidenced by decreased gastric fluid volume, total acidity, free acidity and increase in the pH of the gastric fluid in pylorus-ligated rats. Our studies also revealed that pretreatment with Cedrus deodara significantly reduced the number of ulcer, ulcer score and ulcer index in pylorus-ligated and ethanol treated rats. The antiulcer activity of Cedrus deodara is further supported by histopathological study which showed protection of mucosal layer from ulceration and inflammation. Conclusion: The present findings conclude that volatile oil of Cedrus deodara wood has potent antisecretory and antiulcer effects and justify the traditional usage of this herb to treat peptic ulcers. © 2010 Elsevier Ireland Ltd.


Harminder,Shobhit University | Singh V.,Translam Institute of Pharmaceutical Education and Research | Chaudhary A.K.,Subharti University
Indian Journal of Pharmaceutical Sciences | Year: 2011

Oroxylum indicum Vent. (O. indicum) is a tree commonly called Indian trumpet tree found in tropical countries, such as India, Japan, China, Sri Lanka, Malaysia. The chemical constituents obtained from different parts of plant include baicalein-7-O-diglucoside (Oroxylin B), baicalein-7-O-glucoside, chrysin, apegenin, prunetin, sitosterol, oroxindin, biochanin-A, ellagic acid, baicalein and its 6-and 7-glucuronides, scutellarein, tetuin, antraquinone and aloe-emodin. Various parts of the plant are used in Ayurveda and folk medicine for the treatment of different ailments such as cancer, diarrhea, fever, ulcer and jaundice. Recent in vivo and in vitro studies have indicated its antiinflammatory, antiulcer, hepatoprotective, anticancer, antioxidant, photocytotoxic, antiproliferative, antiarthritic, antimicrobial, antimutagenic and immunostimulant properties. Exhaustive literature survey reveals that there are some activities which are still not proven scientifically. This article is an attempt to compile an up-to-date and comprehensive review on O. indicum covering its traditional and folk medicinal uses, phytochemistry and pharmacology.


Sharma J.,Translam Institute of Pharmaceutical Education and Research | Ahmad S.,Translam Institute of Pharmaceutical Education and Research | Shamsher Alam M.,Translam Institute of Pharmaceutical Education and Research
Journal of Chemical and Pharmaceutical Research | Year: 2012

In recent years, Triazole derivatives have acquired conspicuous significance due to their wide spectrum of biological activities. There is an increasing demand for the preparation of new antimicrobial agents due to the developing resistance towards conventional antibiotics. This review article covers the latest information over active triazole derivatives having different pharmacological action such as, antiviral, anticonvulsant, anti-inflammatory, antibacterial, antifungal and antituberculosis. It can act as an important tool for medicinal chemists to develop newer compounds possessing triazole moiety that could be better agents in terms of efficacy and safety.


Tiwari B.K.,Translam Institute of Pharmaceutical Education and Research | Khosa R.L.,Bharat Institute of Technology
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2010

Berberis asiatica roots have been used for the treatment of affection of eyes, skin, rheumatism and jaundice could be a substitute for endangered species Berberis aristata exhaustively used by industries and in ayurvedic system of medicine. The present investigation describes hepatoprotective and antioxidant activities of dried aerial parts of Berberis asiatica, aqueous (AqBA) and methanol (MeBA) extracts, against CCl4 -induced hepatic injury. Hepatic injury was achieved by injecting 2ml/kg s.c of CCl4 in equal proportion with olive oil. AqBA and MeBA at dose levels of 200 and 300 mg/kg offered significant (P<0.001) hepatoprotective action by reducing the serum marker enzymes like serum glutamate oxaloacetate (SGOT), serum glutamate transaminase (SGPT). They also reduced the elevated level of serum alkaline phosphatase (ALP) serum acid phosphatase (ACP) and serum bilirubin. Reduced enzymic and non nonenzymic antioxidant levels and elevated lipid peroxide level were restored to normal by administration of MeBA and AqBA. Histopathological studies further confirmed the hepatoprotective activity of these extracts when compared with CCl4 treated control groups. The result obtained were compared with silymarin (100mg/kg; p.o), the standard drug. In conclusion MeBA extract at (200mg/kg, p.o) showed significant p<0.001 hepatoprotective activity similar to that standard drug, silymarin.


Garg A.,Translam Institute of Pharmaceutical Education and Research | Singh R.,Mm University
International Journal of Phytomedicine | Year: 2014

Obesity is a chronic disorder of global prevalence and associated with morbidity and mortality. Therefore, attention is being focused on the investigation of plant-based drugs used in the traditional medicine for the treatment of obesity. The presents work evaluates the anti-lipase and antiobesity activity of ethanol and aqueous extracts of Enccostemma ltttorale (ElEe & ElAe) (Genitanaceae) (Synonym - Enicostemma axillare) in HFD induced obesity in rats. Male Wistar rats weighing 150200 g were divided into different group’s i.e. Normal control, HFD control, Orlistat (lipase inhibitor), ElEe & ElAe at doses of 200, 400, 250 and 500 mg/kg p.o. Treatment was started after 6 weeks upto 12 weeks alongwith HFD (except normal control). Oxidative stress was measured by measuring MDA, SOD and GSH level. Obesity was assessed by measuring morphological parameters, serum glucose, serum cholesterol, triglycerides and HDL level. ElEe & ElAe at 200, 400, 250 and 500 mg/kg/orally significantly attenuated morphological parameters i.e. weight gain, BMI, WHR, obesity index and adiposity index respectively as compare to HFD control group. Similarly, serum glucose, triglyceride, total cholesterol and oxidative stress were found to be attenuated as compare to HFD control group. The aqueous and ethanol extracts of Enicostemma littorale exhibit significant anti-lipase and antiobesity activity in high fat diet induced obesity in rats. © 2014, Advanced Research Journals. All rights reserved.


Tiwari B.K.,Translam Institute of Pharmaceutical Education and Research | Khosa R.L.,Bharat Institute of Technology
Internet Journal of Tropical Medicine | Year: 2010

The flower heads of Sphaeranthus indicus Linn (Asteraceae) a traditional Indian medicinal plant is commonly used to nourish and improve the liver conditions. This study was designed to evaluate the hepatoprotective and antioxidant effect of aqueous (AQS) and methanolic (MES) extract of flower heads of Sphaeranthus indicus on Paracetamol (APAP)-induced hepatotoxicity in rat's in-vivo. Activities of liver marker enzymes, glutamate-oxaloacetate transaminase (SGOT) glutamate pyruvate transaminase (SGPT), acid phosphatase (ACP) and alkaline phosphatase (ALP) bilirubin and total protein at an oral dose of MES (300mg/kg) showed a significant hepatoprotective effect in comparison with the same dose of aqueous extract. This fact was also confirmed by studying the liver histopathology of treated animals. As Regards the antioxidant activity, MES exhibited a significant effect (P < 0.05) showing increasing levels of superoxide dismutase (SOD), Catalase (CAT), and glutathione peroxides (GPX) by reducing malondialdehyde (MDA) levels. © Internet Scientific Publications, LLC., 1996 to 2010.


Ali F.,Translam Institute of Pharmaceutical Education and Research
International Journal of Pharma and Bio Sciences | Year: 2015

A simple, precise, sensitive and rapid reverse phase high performance liquid chromatographic method was developed for the estimation of Pantoprazole in bulk and pharmaceutical dosage forms. The method was developed by using Waters X-Bridge C- 18(4.6×150 mm, 5μm) column; mobile phase consisting of ACN and bicarbonate buffer at pH 9.0; the flow rate of 1.0 ml/min and detection wavelength 214nm and eluted at 4.775 min. The linearity ranges were 25 to 125ppm for Pantoprazole. The method was validated as per ICH guidelines for various parameters like linearity, precision, accuracy, LOD, LOQ and robustness. The validated method was applied to the commercially available pharmaceutical dosage forms and obtained the desired result.

Loading Translam Institute of Pharmaceutical Education and Research collaborators
Loading Translam Institute of Pharmaceutical Education and Research collaborators