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Transgene (Paris:TNG), a company focused on designing and developing targeted immunotherapies for the treatment of cancer and infectious diseases, today announced the signature of a collaborative arrangement with UC Davis (USA, California) to support an investigator-initiated study led UC Davis Medical Center that will evaluate TG4010 in combination with Opdivo® (nivolumab) for the treatment of 2nd line metastatic non-small cell lung cancer (NSCLC). This trial is supported by Transgene through financial support and supply of TG4010 and by Bristol-Myers Squibb through supply of nivolumab for use in the clinical study. Karen Kelly, MD, a world-renowned expert of lung cancer and Associate Director for Clinical Research at UC Davis Comprehensive Cancer Center, is the Principal Investigator of this Phase 2 study. The enrollment of the first patients is expected in the coming weeks. TG4010 is an active immunotherapy that has been designed to express the coding sequences of the MUC1 tumor-associated antigen and the cytokine, Interleukin-2 (IL2). TG4010, which is based on a modified vaccinia virus (MVA), induces an immune response against MUC1 expressing tumors, such as non-squamous NSCLC. Its mechanism of action and excellent safety profile make TG4010 a very suitable candidate for combinations with other therapies, such as Opdivo®, a PD-1 immune checkpoint inhibitor that is designed to prevent the PD-1 pathway from suppressing the immune system’s response against tumors. Opdivo® is approved in the USA for the 2nd line treatment of advanced non-small cell lung cancer. This study is a Phase 2, multi-center, single arm, open-label trial. Its primary objective is to evaluate the efficacy (Overall Response Rate) of the combination of TG4010 plus Opdivo® in patients with stage IV non-squamous NSCLC who have progressed after one line of platinum-based chemotherapy. Secondary endpoints include progression-free survival (PFS), overall survival (OS), duration of response and safety. Immunotherapy, particularly the use of immune checkpoint blockers such as the anti-PD-1 Opdivo®, is rapidly transforming cancer care, due to its demonstrated antitumor activity. There is increasing interest among the medical community in exploring whether combining different immunotherapy agents could provide additional benefit to patients. This study will evaluate the efficacy of this combination of immunotherapies that target distinct stages of the immune cycle. Philippe Archinard, Chairman and CEO of Transgene, added: “We are delighted to start a collaboration with a highly respected clinical investigator, Dr. Karen Kelly of UC Davis. We are also glad that Bristol-Myers Squibb, a leader in cancer immunotherapy research, is supporting this trial. The interest from such a leading company in investigating the potential of TG4010 in combination with Opdivo® supports confidence in researching whether our active immunotherapies are complementary to an immune checkpoint inhibitor.” About non-small cell lung cancer Lung cancer is one of the most common malignancies worldwide with an estimated 1.8 million new cases annually. It is also a leading cause of cancer-related deaths, accounting for an estimated nearly 1.6 million deaths in 2012 (Source: GLOBOCAN 2012). NSCLC represents approximately 85% or more of all lung cancers of which about 75% are non-squamous. According to the American Cancer Society, deaths due to lung cancer were expected to account for about 27% of all U.S. cancer deaths in 2015, more than any other cancer type. It is estimated that there will be over 221,000 new cases of lung cancer in the U.S. in 2015 and over 158,000 deaths due to this disease. Recent statistics from GLOBOCAN 2012 estimate that there were over 448,000 cases of lung cancer in Europe in 2012, and over 388,000 people in Europe died from this disease. Advanced lung cancer remains one of the cancer types with the worst prognosis (five-year survival rate for advanced NSCLC of less than 5%), underlining the unmet need in this disease. About TG4010 TG4010 is a novel MUC1 targeting immunotherapy. This therapeutic vaccine is in development for the treatment of metastatic NSCLC. TG4010 is a recombinant vaccinia virus of the Ankara strain (MVA) expressing the coding sequences of the MUC1 antigen and of the cytokine, Interleukin-2 (IL2). In healthy cells, the MUC1 protein is normally found on the surface of epithelial cells in many types of tissue and works to protect these cells. In tumor cells, several modifications of MUC1 can occur: over expression, hypo-glycosylation and changes in cellular localization. These changes transform the MUC1 protein into a highly immunogenic tumor associated antigen (TAA) and make it an attractive target for cancer immunotherapy. Thus, the strategy is to induce MUC1 antigen expression in a non-tumor environment, i.e., where the immune system is fully functional, in order to induce both innate and MUC1 specific adaptive immunity. In addition to NSCLC, the MUC1 TAA is expressed in many other solid tumor types, such as lung, breast, colorectal, kidney and prostate cancers. The results from the Phase 2b part of the Phase 2b/3 TIME trial with TG4010 immunotherapy in non-small cell lung cancer (NSCLC) have been published in the peer-reviewed medical journal, The Lancet Oncology in December 2015. About Transgene Transgene S.A. (Euronext: TNG), part of Institut Mérieux, is a publicly traded French biopharmaceutical company focused on designing and developing targeted immunotherapies for the treatment of cancer and infectious diseases. Transgene’s programs utilize viral vector technology with the goal of indirectly or directly killing cancerous or infected cells. The Company’s two lead clinical-stage programs are: TG4010, a therapeutic vaccine for non-small cell lung cancer, and Pexa-Vec, an oncolytic virus for liver cancer. The Company has several other programs in clinical and pre-clinical development, including TG4001. Transgene is based in Strasbourg, France, and has additional operations in Lyon, in China and in the U.S. Additional information about Transgene is available at www.transgene.com. Disclaimer This press release contains forward-looking statements about the future development of TG4010. Although the Company believes its expectations are based on reasonable assumptions, these forward-looking statements are subject to numerous risks and uncertainties, which could cause actual results to differ materially from those anticipated. The occurrence of any of these risks could have a significant negative outcome for the Company’s activities, perspectives, financial situation, results and development. The Company’s ability to commercialize its products depends on but is not limited to the following factors: positive pre-clinical data may not be predictive of human clinical results, the success of clinical studies, the ability to obtain financing and/or partnerships for product development and commercialization, and marketing approval by government regulatory authorities. For a discussion of risks and uncertainties which could cause the Company’s actual results, financial condition, performance or achievements to differ from those contained in the forward-looking statements, please refer to the Risk Factors (“Facteurs de Risque”) section of the Document de Référence, which is available on the AMF website (http://www.amf-france.org) or on Transgene’s website (www.transgene.fr).


STRASBOURG, France--(BUSINESS WIRE)--Regulatory News: Transgene (Paris:TNG) (Euronext Paris : TNG), société biopharmaceutique qui conçoit et développe des produits d’immunothérapie ciblée contre les cancers et les maladies infectieuses, a présenté ce jour un poster sur des résultats précliniques de TG1050 au Liver Meeting 2016, la réunion annuelle de l’AASLD (American Association for the Study of Liver Disease) qui s’est tenue à Boston (États-Unis). TG1050 est un vaccin thérapeutique pour le tr


News Article | November 21, 2016
Site: www.prnewswire.co.uk

ReportsnReports.com adds "Tuberculosis - Pipeline Review, H2 2016" to its store providing comprehensive information on the therapeutics under development for Tuberculosis (Respiratory), complete with analysis by stage of development, drug target, mechanism of action (MoA), route of administration (RoA) and molecule type. The guide covers the descriptive pharmacological action of the therapeutics, its complete research and development history and latest news and press releases. Complete report on H2 2016 pipeline review of Tuberculosis with 108 market data tables and 17 figures, spread across 393 pages is available at http://www.reportsnreports.com/reports/755901-tuberculosis-pipeline-review-h2-2016.html. Tuberculosis, commonly known as TB, is a bacterial infection that can spread through the lymph nodes and bloodstream to any organ in body. It is most often found in the lungs. The symptoms of tuberculosis range from no symptoms (latent tuberculosis) to symptoms of active disease. Symptoms include overall sensation of feeling unwell; cough, possibly with bloody mucus, fatigue, shortness of breath, weight loss and pain in the chest. Companies discussed in this Tuberculosis Pipeline Review, H2 2016 report include Abera Bioscience AB, Akthelia Pharmaceuticals Limited, Alvogen Korea Co., Ltd., Anacor Pharmaceuticals, Inc., Archivel Farma S.L., AstraZeneca Plc, Beech Tree Labs, Inc., BioDiem Ltd, BioLingus AG, Biomar Microbial Technologies, Bioversys AG, Celgene Corporation, Cellceutix Corporation, Chongqing Zhifei Biological Products Co., Ltd., Crestone, Inc., Dafra Pharma International Ltd., Daiichi Sankyo Company, Limited, Demuris Limited, Eisai Co., Ltd., Eli Lilly and Company, Ensol Biosciences Inc., EpiVax, Inc., FIT Biotech Oy, GangaGen Inc., GlaxoSmithKline Plc, Globeimmune, Inc., Hager Biosciences, LLC, Hsiri Therapeutics LLC, Imaxio SA, Immunitor, Inc., ImmunoBiology Limited, Inovio Pharmaceuticals, Inc., Johnson & Johnson, Lakewood-Amedex Inc, Lipotek Pty Ltd., Matinas BioPharma Holdings, Inc., Microbion Corporation, Microbiotix, Inc., NEARMEDIC PLUS, Ltd, Novartis AG, NovoBiotic Pharmaceuticals, LLC, Otsuka Holdings Co., Ltd., QureTech Bio AB, Recce Pty Ltd, Rodos BioTarget GmbH, Sanofi, Sanofi Pasteur SA, Sarepta Therapeutics, Inc., Sequella, Inc., Shionogi & Co., Ltd., Sphaera Pharma Pvt. Ltd., Spring Bank Pharmaceuticals, Inc., Takeda Pharmaceutical Company Limited, TetraLogic Pharmaceuticals, TGV-Laboratories, Theravectys SA, Tomegavax, Inc., Transgene SA, TVAX Biomedical, Inc., Univalue Valorizacion, S.L., Vaccibody AS, Vakzine Projekt Management GmbH, Vaxil Bio Therapeutics Ltd. and Vichem Chemie Research Ltd. The Tuberculosis (Infectious Disease) pipeline guide also reviews of key players involved in therapeutic development for Tuberculosis and features dormant and discontinued projects. The guide covers therapeutics under Development by Companies /Universities /Institutes, the molecules developed by Companies in Pre-Registration, Phase III, Phase II, Phase I, Preclinical, Discovery and Unknown stages are 1, 5, 7, 8, 61, 37 and 3 respectively. Similarly, the Universities portfolio in Phase III, Phase II, Phase I, Preclinical and Discovery stages comprises 2, 4, 5, 35 and 37 molecules, respectively. Tuberculosis (Infectious Disease) pipeline guide helps in identifying and tracking emerging players in the market and their portfolios, enhances decision making capabilities and helps to create effective counter strategies to gain competitive advantage. The guide is built using data and information sourced from Global Markets Direct’s proprietary databases, company/university websites, clinical trial registries, conferences, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources. Additionally, various dynamic tracking processes ensure that the most recent developments are captured on a real time basis. The report helps in identifying and tracking emerging players in the market and their portfolios, enhances decision making capabilities and helps to create effective counter strategies to gain competitive advantage. Scope of this report: The report provides a snapshot of the global therapeutic landscape of Tuberculosis and reviews pipeline therapeutics for Tuberculosis by companies and universities/research institutes based on information derived from company and industry-specific sources and key players involved Tuberculosis therapeutics and enlists all their major and minor projects. The research covers pipeline products based on various stages of development ranging from pre-registration till discovery and undisclosed stages. The report features descriptive drug profiles for the pipeline products which includes, product description, descriptive MoA, R&D brief, licensing and collaboration details & other developmental activities and assesses Tuberculosis therapeutics based on drug target, mechanism of action (MoA), route of administration (RoA) and molecule type. The report summarizes all the dormant and discontinued pipeline projects with latest news related to pipeline therapeutics for Tuberculosis. ReportsnReports.com is your single source for all market research needs. Our database includes 500,000+ market research reports from over 100+ leading global publishers & in-depth market research studies of over 5000 micro markets. With comprehensive information about the publishers and the industries for which they publish market research reports, we help you in your purchase decision by mapping your information needs with our huge collection of reports. Connect With Us on: Facebook: https://www.facebook.com/ReportsnReports/ LinkedIn: https://www.linkedin.com/company/reportsnreports Twitter: https://twitter.com/marketsreports G+ / Google Plus: https://plus.google.com/111656568937629536321/posts RSS/Feeds: http://www.reportsnreports.com/feed/l-latestreports.xml


News Article | November 9, 2016
Site: www.newsmaker.com.au

The report provides comprehensive information on the therapeutics under development for Basal Cell Carcinoma (Basal Cell Epithelioma) ,complete with analysis by stage of development,drug target,mechanism of action (MoA),route of administration (RoA) and molecule type. The report also coversthe descriptive pharmacological action of the therapeutics,its complete research and development history and latest news and press releases. Additionally,the report provides an overview of key players involved in therapeutic development for Basal Cell Carcinoma (Basal Cell Epithelioma)  and features dormant and discontinued projects. The report helps in identifying and tracking emerging players in the market and their portfolios,enhances decision making capabilities and helps to create effective counter strategies to gain competitive advantage. Complete report on Basal Cell Carcinoma (Basal Cell Epithelioma)  - Pipeline Review,H2 2016 addition with 27 market data tables and 12 figures, spread across 112 pages is available at http://www.rnrmarketresearch.com/basal-cell-carcinoma-basal-cell-epithelioma-pipeline-review-h2-2016-market-report.html This report features investigational drugs from across globe covering over 20 therapy areas and nearly 3,000 indications. The report is built using data and information sourced from Global Markets Direct's proprietary databases,company/university websites,clinical trial registries,conferences,SEC filings,investor presentations and featured press releases from company/university sites and industry-specific third party sources. Drug profiles featured in the report undergoes periodic review following a stringent set of processes to ensure that all the profiles are updated with the latest set of information. Additionally,various dynamic tracking processes ensure that the most recent developments are captured on a real time basis. Biofrontera AG,Biosceptre (Aust) Pty Ltd,Cannabis Science, Inc,Genextra S.p.a.,Ignyta, Inc. Laboratories Ojer Pharma S.L.,MediGene AG,Merck & Co., Inc.,PellePharm, Inc.,Provectus Biopharmaceuticals, Inc.,Redx Pharma Plc,Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd.,Transgene SA Inquire before buying  http://www.rnrmarketresearch.com/contacts/inquire-before-buying?rname=748017(This is a premium report price at US$2000 for a single user PDF license).


News Article | November 15, 2016
Site: www.prnewswire.co.uk

ReportsnReports.com adds "Bladder Cancer - Pipeline Review, H2 2016" to its store, providing comprehensive information on the therapeutics under development for Bladder Cancer, complete with analysis by stage of development, drug target, mechanism of action (MoA), route of administration (RoA) and molecule type. The report also covers the descriptive pharmacological action of the therapeutics, its complete research and development history and latest news and press releases. Additionally, the report provides an overview of key players involved in therapeutic development for Bladder Cancer and features dormant and discontinued projects. Bladder cancer occurs in tissues of the urinary bladder. Symptoms include blood or blood clots in the urine, frequent urination, lower back pain on one side of the body and burning during urination. Risk factors for bladder cancer include smoking, exposure to substances such as rubber, certain dyes and textiles, paint, and hairdressing supplies, diet rich in fried meats and fat, old age, sex and color, certain parasitic infections. Treatment of bladder cancer includes chemotherapy, surgery, biological therapy and radiation therapy. Complete report on Global Bladder Cancer Market Research with 151 market data tables and 17 figures, spread across 742 pages is available at http://www.reportsnreports.com/reports/747719-bladder-cancer-pipeline-review-h2-2016.html . Company Analysis and Positioning discussed in this research are 4SC AG, Adaptimmune Therapeutics Plc, ADC Therapeutics SA, Agenus Inc, Altor BioScience Corporation, AndroScience Corporation, APIM Therapeutics AS, Arno Therapeutics, Inc., Astellas Pharma Inc., Astex Pharmaceuticals Inc, Aura Biosciences, Inc., AVEO Pharmaceuticals, Inc., Azaya Therapeutics, Inc., Bavarian Nordic A/S, Bayer AG BioCancell Ltd, Biomics Biotechnologies Co., Ltd., Bioncotech Therapeutics SL, Biotest AG, Boehringer Ingelheim GmbH, Bristol-Myers Squibb Company, Celgene Corporation, Cellceutix Corporation, Celldex Therapeutics, Inc., Celprogen, Inc., Celsion Corporation, Codagenix, Inc., Cold Genesys, Inc., Corvus Pharmaceuticals Inc, CytomX Therapeutics, Inc., DormaTarg, Inc., Eisai Co., Ltd., Eleven Biotherapeutics Inc., Eli Lilly and Company, Elsalys Biotech SAS, enGene, Inc, Esperance Pharmaceuticals, Inc., Exelixis, Inc., F. Hoffmann-La Roche Ltd., Five Prime Therapeutics, Inc., Gene Signal International SA, Genmab A/S, GlaxoSmithKline Plc, H3 Biomedicine Inc., Hamlet Pharma AB, Heat Biologics, Inc., HEC Pharm Co., Ltd., Hutchison MediPharma Limited, Idera Pharmaceuticals, Inc., ImmuNext, Inc., Immunocore Limited, Immunomedics, Inc., Immupharma Plc, InteRNA Technologies B.V., Johnson & Johnson, LipoMedix Pharmaceutical Inc., MacroGenics, Inc., MaxiVAX SA, Meabco A/S, Medicenna Therapeutics, Inc., MedImmune LLC, Merck & Co., Inc., Merck KGaA, Mirati Therapeutics Inc., Mirna Therapeutics, Inc., Miyarisan Pharmaceutical Company, Ltd, Moleculin Biotech Inc, NanoCarrier Co., Ltd., Nektar Therapeutics, NuCana BioMed Limited, Omeros Corporation, Oncogenex Pharmaceuticals, Inc., Oncolytics Biotech Inc., OncoTherapy Science, Inc., Ono Pharmaceutical Co., Ltd., Optimum Therapeutics, LLC, Pfizer Inc., Pharma Mar, S.A., Philogen S.p.A., Plexxikon Inc., Polaris Pharmaceuticals, Inc., Provectus Biopharmaceuticals, Inc., PsiOxus Therapeutics Limited, Rexahn Pharmaceuticals, Inc., Rodos BioTarget GmbH, Sanofi, Savoy Pharmaceuticals, Inc., Serometrix, LLC, Shionogi & Co., Ltd., Sillajen Biotherapeutics, Sorrento Therapeutics Inc, Spectrum Pharmaceuticals, Inc., Stemline Therapeutics, Inc., Sun Pharma Advanced Research Co Ltd, Synovo GmbH, Taiwan Liposome Company, Ltd., Tara Immuno-Oncology Therapeutics LLC, Taris Biomedical LLC, Telormedix SA, TesoRx Pharma LLC, Theravectys SA, Theryte Limited, Transgene SA, UroGen Pharmaceuticals, Ltd., Vakzine Projekt Management GmbH, Vault Pharma Inc., Vaxeal Holding SA, Vaxiion Therapeutics, Inc. and Viralytics Ltd. The Bladder Cancer (Oncology) pipeline guide also reviews of key players involved in therapeutic development for Bladder Cancer and features dormant and discontinued projects. The guide covers therapeutics under Development by Companies /Universities /Institutes, the molecules developed by Companies in Pre-Registration, Phase III, Phase II, Phase I, IND/CTA Filed, Preclinical and Discovery stages are 1, 9, 44, 35, 2, 56 and 12 respectively. Similarly, the Universities portfolio in Phase II, Phase I, Preclinical and Discovery stages comprises 3, 1, 12 and 2 molecules, respectively. Bladder Cancer (Oncology) pipeline guide helps in identifying and tracking emerging players in the market and their portfolios, enhances decision making capabilities and helps to create effective counter strategies to gain competitive advantage. The guide is built using data and information sourced from Global Markets Direct’s proprietary databases, company/university websites, clinical trial registries, conferences, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources. Additionally, various dynamic tracking processes ensure that the most recent developments are captured on a real time basis. ReportsnReports.com is your single source for all market research needs. Our database includes 500,000+ market research reports from over 100+ leading global publishers & in-depth market research studies of over 5000 micro markets. With comprehensive information about the publishers and the industries for which they publish market research reports, we help you in your purchase decision by mapping your information needs with our huge collection of reports. Connect With Us on:


News Article | January 28, 2016
Site: phys.org

The ability of Group A Streptococcus (GAS) to induce rapid destruction of red blood cells has been observed for more than a century and remains a clinical hallmark of GAS diagnosis. This destruction is due to the production of a small peptide toxin by GAS known as Streptolysin S (SLS). Although it has been widely held that SLS exerts its lytic activity—the excessive destruction of red blood cells—through membrane disruption, its exact mode of action has remained unknown. "Recent molecular studies by our lab and others have demonstrated that SLS is a peptide toxin linked to a broad class of bacterially produced compounds known as bacteriocins," Shaun Lee, an associate professor of biological sciences at the University of Notre Dame, said. "Many of these related bacteriocins have defined cellular targets and have not been shown to function as general lytic agents of cellular membranes." In a new study, Lee's research group provides the first real-time, high-resolution observation of Group A streptoccocal red cell destruction, also called beta-hemolysis. "We demonstrate that the long-observed red blood cell hemolysis by SLS is not caused by general destruction of the red blood cell membrane, as has been previously thought, but rather that the action is due to the ability of the SLS toxin to directly target a specific outer membrane protein on the surface of the red blood cell, the major erythrocyte anion exchange protein Band 3." Importantly, chemical inhibition of Band 3 function completely blocked the hemolytic activity of SLS, and significantly altered the pathology induced by GAS in an in vivo skin infection model. "Our studies provide the first mechanistic look into the longstanding question of SLS function and, importantly, open new therapeutic avenues for the treatment of severe GAS disease," Lee said. "This was a wonderful collaborative effort led by Dustin Higashi, a senior researcher in my lab, to try to answer the longstanding mystery of how this very powerful toxin known as Streptolysin S lyses red blood cells to contribute to invasive human disease caused by the Group A Streptococcus," he said. "Findings critical to the support of our hypothesis were provided by in vivo studies performed at the W.M. Keck Center for Transgene Research, under the direction of Francis Castellino and Victoria Ploplis. Using humanized mouse models, Keck scientists Deborah Donahue and Jeff Mayfield demonstrated that by blocking the action of SLS toxin during a GAS infection, the pathology at the site of the infection could be drastically reduced. These findings have tremendous potential for developing novel therapeutics to treat severe diseases caused by Group A Streptococcus." More information: Dustin L. Higashi et al. Activation of band 3 mediates group A Streptococcus streptolysin S-based beta-haemolysis, Nature Microbiology (2016). DOI: 10.1038/nmicrobiol.2015.4


WiseGuyReports.Com Publish a New Market Research Report On – “Immunotherapy Drugs Market Global Potential Growth,Share,Demand and Analysis Of Key Players Research Report Forecasts to 2020”. This market research report presents a comprehensive segmentation of the global immunotherapy drugs market by type of immunotherapy (mAbs, vaccines, immune checkpoint inhibitors, non-specific immunotherapies, and others), by therapy area (oncology, infectious disease, autoimmune and inflammatory disorders, respiratory diseases, and others), and by geography (the Americas, APAC, and EMEA). Key vendors are AbbVie, Amgen, Bristol-Myers Squibb, F.Hoffmann-La Roche, Johnson & Johnson, and Merck. Overview of the global immunotherapy drugs market  The market research analyst predicts that the global immunotherapy drugs market will grow at a steady CAGR of close to 12% by 2020. During a rise in cancer and a number of autoimmune diseases, the need for immunotherapy drugs is on the rise. Furthermore, with the increasing demand for mAbs, the market for immunotherapy drugs will have a positive outlook until the end of the forecast period. mAbs have a high affinity for specific disease cells and areas that need treatment. Consequently, they can be used for therapies like radioimmunotherapy and antibody-directed enzyme prodrug therapy. The augmented usage of these antibodies in drug development will help to bolster the market’s revenue generating capacity over the course of the next four years. For more information or any query mail at [email protected] An important factor impelling the prospects for growth in this market is the emergence of biosimilars. Unlike generic drugs, which have active pharmaceutical ingredients similar to original drugs, biosimilars are almost identical to their originator biologic compounds. Since biosimilars help to make treatments more accessible to patients and are less expensive than biologics, their sale among the end users is anticipated to increase significantly over the next few years. Segmentation by type of immunotherapy and analysis of the immunotherapy drugs market  - mAbs  - Vaccines  - Immune checkpoint inhibitors  - Non-specific immunotherapies During 2015, the mAbs segment dominated this market and accounted for an impressive market share of nearly 61%. The development of new drugs and the entry of new molecules like zanolimumab, elotuzumab, obinutuzumab, and onartuzumab into the market will aid in the growth of this market segment during the forecast period. Geographical segmentation and analysis of the immunotherapy drugs market  - Americas  - APAC  - EMEA The Americas dominated the global market with over 50% market share in 2015. The market is flourishing in this region due to the higher incidences of cancer, infectious diseases, and autoimmune diseases in the US. Additionally, factors such as the high affordability of therapies due to the presence of well-structured reimbursement plans will also spur the prospects for market growth until 2020. Competitive landscape and key vendors  The global market for immunotherapy drugs is highly competitive due to the presence of a number of large and small vendors. Many of these vendors have a huge global presence and enter into strategic alliances to aid in the manufacture and marketing of essential drugs. Safety and effectiveness of drugs are key factors, which will give vendors an edge in the marketplace. Key vendors in this market are - AbbVie  Amgen  Bristol-Myers Squibb  F.Hoffmann-La Roche  Johnson & Johnson  Merck  Other prominent vendors are AB Science. Ablynx, Acorda Therapeutics, ADC Therapeutics, Aduro Biotech, Advantagene, Advaxis, Agensys, Agenus, Alder Biopharmaceuticals, AlphaVax, Altor BioScience, Antares Pharma, Antigen Express, Argos Therapeutics, Astellas Pharma, AstraZeneca, AVAX Technologies, Bavarian Nordic, Baxter, Bayer, Biogen, Biotech Pharmaceutical, Biothera, Boehringer Ingelheim, Can-Fite BioPharma, Celgene, Celldex Therapeutics, Celltrion, Cel-Sci, ChemoCentryx, Chugai Pharmaceutical, Coherus BioSciences, CTI BioPharma, CureVac, Daiichi Sankyo, Eisai, Eli Lilly, Fortress Biotech, Galena Biopharma, Genexine, Genmab, Gilead Sciences, GSK, GlobeImmune, Gradalis, Heat Biologics, Hospira, Idera, Inmatics, ImmunoCellular Therapeutics, Immunomedics, ImmuPharma, Immutep, Incyte, Inovio Pharmaceuticals, Intas Pharmaceuticals, Invion, ISA Pharmaceuticals, Janssen Biotech, Juvaris Biotherapeutics, KaloBios Pharmaceuticals, Kyowa Hakko Kirin, Lexicon Pharmaceuticals, MedImmune, Morphotek, Neovii Biotech, Northwest Biotherapeutics, Novartis, NovaRx, Novo Nordisk, OncoMed Pharmaceuticals, Oncothyreon, Oncovir, Opexa Therapeutics, Oxford BioMedica, Pfizer, Prima BioMed, Principia, Progenics, Provectus Biopharmaceuticals, Regeneron, Sandoz, Sanofi, Santarus, Seattle Genetics, Sotio, Spectrum Pharmaceuticals, Takeda, TG Therapeutics, Transgene, UbiVac, UCB, Vaccinex, Vaccinogen, Vaxon Biotech, Vertex Pharmaceuticals, Vical, Vitae Pharmaceuticals, and XBiotech. Key questions answered in the report include  - What will the market size and the growth rate be in 2020?  - What are the key factors driving the global immunotherapy drugs market?  - What are the key market trends impacting the growth of the global immunotherapy drugs market?  - What are the challenges to market growth for immunotherapy drugs?  - Who are the key vendors in the global immunotherapy drugs market?  - What are the market opportunities and threats faced by the vendors in the immunotherapy drugs market?  - Trending factors influencing the market shares of the Americas, APAC, and EMEA.  - What are the key outcomes of the five forces analysis of the global immunotherapy drugs market? For more information or any query mail at [email protected] Wise Guy Reports is part of the Wise Guy Consultants Pvt. Ltd. and offers premium progressive statistical surveying, market research reports, analysis & forecast data for industries and governments around the globe. Wise Guy Reports features an exhaustive list of market research reports from hundreds of publishers worldwide. We boast a database spanning virtually every market category and an even more comprehensive collection of market research reports under these categories and sub-categories.


News Article | November 9, 2016
Site: www.newsmaker.com.au

The Global market for Therapeutic vaccines is expected to reach US $4.82 billion by the end of 2020 growing at a CAGR of around 33.6% from 2015 to 2020. Several new approaches are being developed in order to boost the immune response to the cancerous cells.These technical advancements are expected to add powerful new components to the standard cancer treatments.In the pipeline, therapeutic vaccines are also in development to treat infectious diseases such as the Human Immunodeficiency Virus (HIV), neurological disorders such as Alzheimers disease, autoimmune disorders such as rheumatoid arthritis and multiple sclerosis, and other conditions such as hypertension. The Global Therapeutic Vaccines Market is segregated on the basis of Autoimmune Disease Vaccines (Type I Diabetes), Neurological Disease Vaccines (CAD106, ACC-001, Alzheimer's Disease, Parkinsons Disease Vaccine and Other Disease Vaccines), Cancer Vaccines (TroVax, PR1 Peptide Vaccine, Multikine, CYT004-MelQbG10 etc..), and Infectious Disease Vaccines (HIV/AIDS, Hepatitis C, and Other Infectious Disease Vaccines) & Region (North America, Europe, Asia Pacific & Rest of the World). The Favorable government funding for vaccine development, increasing investments by the companies Technological advancements, rising prevalence of disease are the major factors that are driving the market growth. Huge capital expenditures and Stringent Regulatory policies are hindering the market growth. What the report offers:  • Market Definition for the specified topic along with identification of key drivers and restraints for the market.  • Market analysis for the Global Therapeutic vaccines Market in Healthcare Industry, with region specific assessments and competition analysis on a global and regional scale.  • Identification of factors instrumental in changing the market scenarios, rising prospective opportunities and identification of key companies which can influence the market on a global and regional scale.  • Extensively researched competitive landscape section with profiles of major companies along with their strategic initiatives and market shares.  • Identification and analysis of the Macro and Micro factors that affect the Global Therapeutic vaccines Market in Healthcare Industry on both global and regional scale.  • A comprehensive list of key market players along with the analysis of their current strategic interests and key financial information. Introduction  Study Deliverables  Market Definition  Sizing Units  Base Currency  Review and Forecast Period Years  General Study Assumptions  Research Methodology  Introduction  Analysis Methodology  Econometric Forecast Model  Research Assumptions  Executive Summary  Key Inferences  Market Characterisation  Current Market Scenario  Market Overview  New Developments  Porter’s Five Forces  Bargaining Power of Suppliers  Bargaining Power of Consumers  Threat of New Entrants  Threat of Substitute Products and Services  Competitive Rivalry within the Industry  Drivers, Restraints, Opportunities, and Challenges (DROC) Analysis  Drivers  Restraints  Opportunities  Challenges  Therapeutic Vaccines Market Segmentation  By Types  Autoimmune Disease Vaccines  Neurological Disease Vaccines  Cancer Vaccines  Infectious Disease Vaccines  By Geography  Asia Pacific  Europe  North America  Middle East and North Africa  Latin America  Competitive Landscape  Merger and Acquisition Analysis  New Product Launches  Agreements, Collaborations & Partnerships  Company Profiling  Antigenics  Bavarian Nordic  Celtic Pharma  Curevac  Cytos Biotechnology  GlaxoSmithKline  Pfizer  Merck Kgaa (Merck Serono)  Novartis  Transgene  Vaccinogen  Analyst Outlook for Investment Opportunities  Future Outlook of the Market


News Article | December 15, 2016
Site: globenewswire.com

Lyon, 15 December 2016, ELSALYS BIOTECH announces the acquisition of development and marketing rights for TG3003 anti-CD115 (as of now ELB041) from TRANSGENE, a monoclonal antibody that inhibits a highly immunosuppressive macrophage subpopulation: type-2 macrophages. In exchange for the license granted to ELSALYS BIOTECH (along with all related sublicensing rights), TRANSGENE will be eligible to receive milestone payments until the medicinal product is registered and will receive royalties based on future sales. M-CSF is a cytokine essential to the survival and differentiation of myeloid lineage cells (monocytes, macrophages, dendritic cells.). The M-CSF receptor (M-CSF-R or CD115) therefore proves to be a promising therapeutic target to modulate the activity of some of these cells, notably those implicated in the tumoral progression as the Tumor Associated Macrophages (TAM). These TAM are in effect made up of 2 subpopulations: the so-called type M1 « tumor killers » macrophages and the type M2 macrophages that suppress the immune response and promote the growth and dissemination of cancer cells.  Thus, in most cancers, the strong presence of these M2 macrophages in the center of the tumor is seen as a factor of poor prognosis The first studies conducted by TRANSGENE with the anti-CD115 ELB041 demonstrate the latter could counter this deleterious effect: it lifts the immunosuppression mediated by the M2 macrophages (Immune Checkpoint Inhibitor or ICI) while restoring the ability of the immune system to destroy the tumor cells (Antibody-Dependent Cell-mediated Cytotoxicity or ADCC). In the light of these encouraging data, ELSALYS BIOTECH will now initiate a preclinical study targeting proof-of-concept in immuno-oncology "ELB041 possesses unique properties. Beyond its dual mechanism of action, it selectively inhibits the formation of M2 macrophages and, unlike the anti-CD115s under development, does not block the interaction between M-CSF and its receptor, CD115, but modulates its activity. Therefore, it should not induce an increase, potentially toxic, in the concentration of serum M-CSF thereby maintaining the viability of myeloid cells. Alone or in combination, it has a favorable efficacy/toxicity ratio." Dr. Jacques MIZRAHI, Scientific Director at ELSALYS BIOTECH, pointed out. "Our goal now is to undertake a clinical assessment of anti-CD115 before the end of 2018." "This new antibody provides a wonderful opportunity for ELSALYS BIOTECH. It highlights the trust we have received from TRANSGENE, which is one of the company's founding shareholders, but also a leader in immunotherapy which intends to focus on therapeutic vaccines and oncolytic viruses" said Dr. Christine GUILLEN, CEO and Co-founder of ELSALYS BIOTECH. "This licensing agreement consolidates our position in immunotherapy antibodies targeting tumors and their immune and/or vascular microenvironment. We now have five development programs in this field, giving ELSALYS BIOTECH an optimum risk profile." ELB041 is a humanized antibody, potentially "best-in-disease", that targets CD115, the M-CSF (Macrophage Colony-Stimulating Factor) found on the surface of macrophages and, more generally, on all cells in the so-called myeloid lineage. An active member of the organism's first line of defense, macrophages are cells with a dual personality: nested in the heart of tumors, some of them promote the immune reaction and contribute to tumor destruction (M1 macrophages), whereas others (M2 macrophages) promote the growth and dissemination of cancer cells and slow the action of the lymphocytes that eliminate them. Many clinical studies have demonstrated that patients dealing with tumors that are highly infiltrated by M2 macrophages run a high risk of relapse. More recently, scientists have discovered that macrophages' functions actually evolve in response to changes in the tumor microenvironment. These studies led TRANSGENE to develop an antibody that is able to inhibit the activity of these deleterious macrophages. In a first series of in vitro and in vivo studies TRANSGENE has already shown that anti-CD115: ELSALYS BIOTECH is a fast-growing biotechnology company that designs and develops "best-in-disease" therapeutic antibodies that target tumors and their immune and/or vascular microenvironment. By restoring the ability of immune cells to recognize and kill tumors (Immune Checkpoint Inhibitors or ICI) or by blocking the mechanisms that promote their growth (targeted antibodies), ELSALYS BIOTECH widens the range of combinations of oncology and ophthalmology in novel strong potential therapeutic targets. To drive its developments, the company relies on an academic network of international standing, an R&D platform that covers from targets sourcing to clinical development of drug candidates and a team of experts with solid experience in immuno-oncology, antibodies development and partnerships. Today ELSALYS BIOTECH has five R&D proprietary development programs in oncology and in ophthalmology. Founded in 2013, ELSALYS BIOTECH is made up of a team of 14 people and managed by Dr Christine GUILLEN. Its founding shareholders are Transgene and Sofimac Partners, joined by IM Europe and Crédit Agricole Création in 2015. The company is located in the heart of the Biodistrict Lyon Gerland.


STRASBOURG, France--(BUSINESS WIRE)--#HBV--Regulatory News: Transgene (Paris:TNG) (Euronext Paris: TNG), a company focused on designing and developing targeted immunotherapies for the treatment of cancer and infectious diseases, today presented a poster on TG1050 preclinical results at the AASLD (American Association for the Study of Liver Diseases) Liver Meeting 2016, Boston (MA). TG1050 is a therapeutic vaccine for the treatment of chronic hepatitis B (or HBV1 infection). The abstract published in

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