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Saint Petersburg, Russia

Grigorian A.S.,Trans Tekhnologii Company | Gilerovich E.G.,Russian Academy of Medical Sciences | Pavlichenko N.N.,Trans Tekhnologii Company | Kruglyakov P.V.,Trans Tekhnologii Company | And 2 more authors.
Bulletin of Experimental Biology and Medicine | Year: 2011

We studied the effect of various methods of transplantation of mesenchymal stem cells on neuronal survival in rat brain 1 and 6 weeks after severe traumatic brain injury. It was found that intracerebral and systemic transplantation of mesenchymal stem cells improves neuronal survival in the piriform cortex of the contralateral hemisphere without affecting neuronal survival in the marginal zone of the traumatic cavity and amygdaloid nuclei. Intracerebral transplantation of mesenchymal stem cells increases the content of the astroglial component of the scar in the borderline zone of the traumatic cavity. © 2011 Springer Science+Business Media, Inc. Source


Kalmykova N.V.,Trans Tekhnologii Company | Skorobogataya E.V.,Trans Tekhnologii Company | Berestovoy M.A.,Trans Tekhnologii Company | Kruglyakov P.V.,Trans Tekhnologii Company | And 3 more authors.
Bulletin of Experimental Biology and Medicine | Year: 2011

We studied the effect of platelet lysates from different donors on fi broblast growth in culture. In most samples (40 of 50), the growth-stimulating characteristics were greater than in 10% FCS, but every ninth sample exhibited low mitogenic activity. A weak dependence between platelet concentration and total protein content was noted, but no correlation was found between these parameters and fi broblast growth in culture. © 2011 Springer Science+Business Media, Inc. Source


Sokolova I.B.,Trans Tekhnologii Company | Gilerovich E.G.,Trans Tekhnologii Company | Pavlichenko N.N.,Trans Tekhnologii Company | Polyntsev D.G.,Trans Tekhnologii Company
Bulletin of Experimental Biology and Medicine | Year: 2012

We performed morphological analysis of the structure of rat hippocampus after ablation of the left sensorimotor cortex. Four experimental groups were formed: two control groups (intravenous and intracerebral injections of the culture medium) and two experimental groups (intravenous and intracerebral transplantation of MSC). Ten weeks after surgery, disturbed cytoarchitectonics and great number of dead neurons were found in all zones of the hippocampus in animals of the control groups. In animals receiving cell therapy, no pathological changes in the structure of the hippocampus were found: hyperchromatic neurons were absent and the cells had regular shape and closely adjoined to each other. © 2012 Springer Science+Business Media, Inc. Source

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