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Stara Zagora, Bulgaria

The Trakia University or Thrace University is a Bulgarian university in the city of Stara Zagora. It was named after the historical region of Thrace and was established in 1995. The university's structure includes colleges in Sliven, Haskovo and Yambol.The university organizes training on programs with four educational and qualification degrees: Specialist, Bachelor, Master and PhD, as well as on programs for qualification and post-graduate training in the system of lifelong education.Trakia University has legitimate institutional accreditation by resolution of the National Assessment and Accreditation Agency at the Council of Ministers. Graduate students receive a diploma stamped with the state coat of arms of the Republic of Bulgaria . Wikipedia.

Dinev I.,Trakia University
Journal of Poultry Science

The aim of the present work is to make a review on the literature concerning the incidence of some major pathologies of leg skeleton in broiler chickens and broiler breeders, related to poor animal welfare. On the basis of data on the incidence of leg skeletal pathology published by us and by other researchers, this review goes through some reports on femoral head necrosis (FHN), tibial dyschondroplasia (TD), rupture of the gastrocnemius tendon (RGT) and rickets. The welfare of broiler chickens and breeder flocks continues to be closely related to leg skeletal pathology. Although some reports establish that most abnormalities related to legs in chickens were largely overcome by selection work and improvement of production systems by the end of the 20th century, the problems still occupy an important place in broiler production. Apart published literature data, own results from the last decade (2001-2011) were also used. © 2012, Japan Poultry Science Association. Source

Background and aim: The aim of the present work was to analyze the expression of antioxidant enzymes GST-pi, SOD1, and SOD2 in endocrine cells of colorectal cancers and to evaluate the significance of the presence of thus labeled endocrine cells as prognostic factor. Methods: The expression of chromogranin A (ChGA), GST-pi, SOD1, and SOD2 was determined in endocrine cells of 128 colorectal cancers using light and electron immunohistochemistry and double immunogold labeling method. Results: Endocrine cells expressing at least one of the studied antioxidant enzymes were detected in a relatively small proportion of primary colorectal cancers (22 cases, 17%; 14% GST-pi-positive, 14% SOD1-positive, and 9% SOD2-positive). The double immunogold staining and the following electron microscopy showed that GST-pi, SOD1, and SOD2 were co-localized with ChGA to the granules of most endocrine cells. The survival analyses revealed that patients with endocrine cells in primary tumor tissues expressing GST-pi had worse prognosis after the surgical therapy than those without GST-pi-positive endocrine cells (median of 22.70 vs. 49.43 months, p∈<∈0.05, Log-rank test). Conclusions: Most of the ChGA-positive endocrine cells in colorectal cancers also expressed some or all of the three studied antioxidant enzymes, GST-pi, SOD1, and SOD2. Moreover, patients having tumors with GST-pi-positive endocrine cells have an unfavorable prognosis. We suggest that not the neuroendocrine differentiation in general, but the presence in the tumors of endocrine cells with activated antioxidant defense and probably metabolically more active might determine a more aggressive type of cancer leading to worse prognosis for patients. © 2010 Springer-Verlag. Source

The protective effects of various feed supplements against the harmful effect of ochratoxin A on egg production and sexual maturation of two-weeks old Plymouth Rock female chicks designed for laying hens were studied. A significant protective effect of the feed additives or materials: water extract of artichoke (WEA), sesame seed (SS), Roxazyme-G (RG) and l-β phenylalanine (PHE) against the suppressive effect of ochratoxin A (OTA) on egg production of laying hens was found. A similar protection was also seen on the toxic effect of OTA on various internal organs of the same hens. A significant protection was found against the decrease of the weight or the quantity of eggs as well as against the delay of the beginning of the laying period of chicks, both of which were provoked by ochratoxin A. These protective effects were strongest in chicks treated with SS or WEA, but were slightest in chicks treated with l-β PHE. © 2009 Elsevier Ltd. Source

Stoev S.D.,Trakia University
Critical Reviews in Food Science and Nutrition

The possible hazard of mycotoxin occurrence in foods and feeds and some food-borne mycotoxicoses is reviewed. Management of the risk of mycotoxin contamination using some useful preventive measures against mycotoxin contamination of foods/feeds during pre- and post-harvesting periods is considered. The physical and chemical methods of mycotoxin decontamination of foods/feeds are briefly described. The use of various feed additives as a method for prevention of the adverse effects of mycotoxins is reviewed. The processing of various foods and feeds is considered in a view to possible mycotoxin decontamination. The necessary hygiene control and risk assessment in regard to mycotoxin contamination of foods and feeds in addition to some useful prophylactic measures are briefly described. A short reference is made concerning the most successful methods of veterinary hygiene control in order to prevent a possible entering of some mycotoxins in commercial channels with a view to human health. © 2013 Copyright Taylor and Francis Group, LLC. Source

Carcinogenic/toxic effects of ochratoxin A (OTA) in various internal organs of Plymouth Rock chicks were determined. The number of OTA-induced neoplasms was similar in chicks given 25 ppm L-β-phenylalanine (PHE) in addition to 5 ppm OTA compared to chicks given only 5 ppm OTA, which showed that PHE cannot be used as a real protector against the carcinogenic or toxic effects of OTA in chicks. OTA was found to provoke strong degenerative changes in liver and kidneys, degenerative changes and depletion of cells in lymphoid organs, oedematous and degenerative changes in the brain, muscular haemorrhages and fatty changes in the bone marrow. The target organs for carcinogenic effect of OTA in chicks were found to be kidneys and liver. © 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. Source

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