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Liu Y.-P.,Chinese Traditional Medicine Hospital | Liang C.-H.,Southern Medical University | Zhang S.-X.,Southern Medical University | Liu B.,Chinese Traditional Medicine Hospital | Ran P.-C.,Chinese Traditional Medicine Hospital
Chinese Journal of Radiology

Objective: To evaluate blood oxygen level-dependent (BOLD) MRI on assessing renal damage after injection of iodine contrast medium with a 3.0 T system. Methods: Routine MRI examination, including T 1WI and T 2WI, and BOLD MRI were performed in 29 SD rats with a 3.0 T system before the injection of iodine contrast agent and 20 min, 24 h, 48 h, 72 h after the injection, respectively. T 2* and R 2* (= 1/T 2*) measurements were obtained in the cortex, inner and outer medulla of kidney, respectively. The results obtained before contrast agent administration were considered as the self-controls. AVONA test were used for the comparison of R 2* values in different parts of both kidneys before contrast agent administration. Two-sample t test was used to compare R 2* values before and at each time point after contrast agent administration, and R 2* values in different parts of the kidneys. Results: Before contrast agentadministration, R 2* values in outer medulla in both sides of kidney [R 2* left OM = (31.76±2.73)/s, R 2* right OM = (32-77±3.07)/s] were higher than those in cortex [R 2* left C = (30.20±3.48)/s, R 2* right c = (28.84±3.11)/s] and in inner medulla [R 2* left IM = (29.54±2.42)/s, R 2* right IM = (28.37±2.80)/s] (F = 3.357 and 14.961, P<0.05). There was no statistical significance in R 2* values in the three parts between left and right kidney, including cortex, outer and inner medulla (P>0.05). After contrast agent administration, R 2* values in outer medulla changed obviously, which reached to the peak values at 20 minutes after contrast agent administration [R 2* left OM = (43-57±3.84)/s, R 2* right OM = (44.58±3.13)/s] and dropped from 24 hours [R 2* left OM = (42.07±4.82)/s, R 2* right OM = (42-89±3.40)/s]. R 2* values in inner medulla and cortex only presented slight changes. Conclusion: R 2* values reflected the changes of oxygen content in renal cortex and medulla quantitatively, which helped for detecting medullar ischemia and hypoxia. BOLD MR imaging could offer a feasible method for evaluating oxygen metabolism and renal injury in cortex and medulla. © 2010 by the Chinese Medical Association. Source

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