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Toyohashi, Japan

Uchiya K.-I.,Meijo University | Takahashi H.,Kainan Hospital Aichi Prefectural Welfare Federation of Agricultural Cooperatives | Nakagawa T.,National Hospital Organization | Yagi T.,Nagoya University | And 7 more authors.
PLoS ONE | Year: 2015

Mycobacterium avium complex (MAC) causes mainly two types of disease. The first is disseminated disease in immunocompromised hosts, such as individuals infected by human immunodeficiency virus (HIV). The second is pulmonary disease in individuals without systemic immunosuppression, and the incidence of this type is increasing worldwide. M. avium subsp. hominissuis, a component ofMAC, causes infection in pigs as well as in humans. Many aspects of the different modes of M. avium infection and its host specificity remain unclear. Here, we report the characteristics and complete sequence of a novel plasmid, designated pMAH135, derived from M. avium strain TH135 in an HIV-negative patient with pulmonary MAC disease. The pMAH135 plasmid consists of 194,711 nucleotides with an average G + C content of 66.5% and encodes 164 coding sequences (CDSs). This plasmid was unique in terms of its homology to other mycobacterial plasmids. Interestingly, it contains CDSs with sequence homology to mycobactin biosynthesis proteins and type VII secretion system-related proteins, which are involved in the pathogenicity of mycobacteria. It also contains putative conserved domains of the multidrug efflux transporter. Screening of isolates from humans and pigs for genes located on pMAH135 revealed that the detection rate of these genes was higher in clinical isolates frompulmonary MAC disease patients than in those from HIV-positive patients, whereas the genes were almost entirely absent in isolates from pigs. Moreover, variable number tandem repeats typing analysis showed that isolates carrying pMAH135 genes are grouped in a specific cluster. Collectively, the pMAH135 plasmid contains genes associated with M. avium's pathogenicity and resistance to antimicrobial agents. The results of this study suggest that pMAH135 influence not only the pathological manifestations of MAC disease, but also the host specificity of MAC infection. © 2015 Uchiya et al.


Umeda Y.,Toyohashi Medical Center
Kyobu geka. The Japanese journal of thoracic surgery | Year: 2011

Pleomorphic carcinoma is a rare primary lung cancer with a poor prognosis. We report a surgically treated case of pleomorphic carcinoma of the lung. An abnormal shadow was incidentally detected by computed tomography (CT) scan for an 80-year-old male. CT scan performed 1 month before the detection of tumor was normal. Right upper lobectomy with ND2a was performed after 5 months follow-up by CT scan because of the enlargement of the tumor. Histological examination showed numerous atypical spindle cells with massive necrosis, diagnosing as pleomorphic carcinoma. Only 2 months after operation, multiple metastases to the lung, chest wall, pleura, and small intestine were found.


Umeda Y.,Toyohashi Medical Center
Kyobu geka. The Japanese journal of thoracic surgery | Year: 2011

Between March 2005 and September 2009, 41,827 patients visited our emergency outpatient clinic, and 50 patients (0.12%) were admitted to our institution for chest trauma. Seventy percent of the chest traumas were caused by traffic accidents. Eighty-five percent of the traffic accidents were associated with car driving or motorcycle driving. Rib fracture, pneumothorax, hemothorax, and lung injury were seen in 56%, 40%, 22%, and 28% of the patients, respectively. Chest tube drainage was performed in 36% of the patients. Sixty-two percent of the patients with chest trauma underwent conservative follow-up. Only 1 patient underwent the ligation of the intercostal artery. One patient with chest trauma and fracture of the cervical vertebra and the pelvis died, who was in the state of cardio-pulmonary arrest on arrival. Forty-nine patients were discharged in 15.2 +/- 17.0 days. Twenty-two percent of the patients were hospitalized only 1 night.


We report a case in which the double-patch technique was used to repair residual shunt after infarct exclusion technique for post-infarction ventricular septal perforation (VSP). A 68-year-old man was diagnosed with post-infarction VSP and surgical interveniton was performed by infarct exclusion technique through left ventriculotomy. Residual shunt was observed by left ventriculography, and he developed cardiac failure in spite of medical therapy. Additional surgery for residual shunt was performed 5 months after the initial operation. The VSP was closed with 2 pericardial patches onto both sides of the septum through right ventriculotomy. Complete closure of the defect was accomplished, and no residual shunt was observed by post-operative left ventriculography. The patient has been doing well with no signs of cardiac failure.


Ikeda M.,Nagoya University | Makino R.,Toyohashi Medical Center | Imai K.,Nagoya University
Australasian Physical and Engineering Sciences in Medicine | Year: 2012

We have proposed a direct evaluation method concerning preservation of noise-free components for image noise reduction. This evaluation method is to graphically estimate how well a noise-reduction method will preserve noise-free image components by using the normal probability plot of the image pixel value difference between an original image and its noise-reduced image; this difference is equivalent to the "method noise" which was defined by Buades et al. Further, by comparing the linearity of a normal probability plot for two different noise reduction methods, one can graphically assess which method will be more able to preserve the noise-free component than the other. As an illustrative example of this evaluation method, we have evaluated the effectiveness of the spatially-adaptive BayesShrink noise-reduced method devised by Chang et al., when applied to chest phantom CT images. The evaluation results of our proposed method were consistent with the visual impressions for the CT images processed in this study. The results of this study also indicate that the spatially-adaptive BayesShrink algorithm devised by Chang et al. will work well on the chest phantom CT images, although the assumption for this method is often violated in CT images, and the assumption postulated for the spatially-adaptive BayesShrink method is expected to have sufficient robustness for CT images. © 2012 Australasian College of Physical Scientists and Engineers in Medicine.

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