Kōtō-ku, Japan
Kōtō-ku, Japan

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Kurita K.,Seikei University | Matsumura Y.,Seikei University | Takahara H.,Seikei University | Hatta K.,Toyo Suisan Kaisha Ltd. | Shimojoh M.,Toyo Suisan Kaisha Ltd.
Biomacromolecules | Year: 2011

N-Acetyl-d-glucosamine branches were incorporated at the C-6 position of curdlan, a linear β-1,3-d-glucan, and the resulting nonnatural branched polysaccharides were evaluated in terms of the immunomodulation activities in comparison with lentinan, a β-1,3-d-glucan having d-glucose branches at C-6. To incorporate the amino sugar branches, we conducted a series of regioselective protection-deprotections of curdlan involving triphenylmethylation at C-6, phenylcarbamoylation at C-2 and C-4, and detriphenylmethylation. Subsequent glycosylation with a d-glucosamine-derived oxazoline, followed by deprotection gave rise to the branched curdlans with various substitution degrees. The products exhibited remarkable solubility in both organic solvents and water. Their immunomodulation activities were determined using mouse macrophagelike cells, and the secretions of both the tumor necrosis factor and nitric oxide proved to be significantly higher than those with lentinan. These results conclude that the amino sugar/curdlan hybrid materials are promising as a new type of polysaccharide immunoadjuvants useful for cancer chemotherapy. © 2011 American Chemical Society.


Kumano H.,Shinshu University | Hirata T.,Shinshu University | Kobayashi Y.,Toyo Suisan Kaisha Ltd.
International Journal of Refrigeration | Year: 2012

The flow and heat transfer characteristics of a tetra-n-butyl ammonium bromide (TBAB) hydrate slurry were investigated experimentally. The characteristics in the transition region were examined in detail. Two types of hydrates form from TBAB solution of different concentrations. The hydrate type, Reynolds number and solid fraction were varied as experimental parameters and the coefficients of pipe friction and heat transfer were measured. In the low solid fraction region, it was found that the coefficients of pipe friction and heat transfer were constant and the values were the same as that for turbulent flow of the TBAB solution. However, for the high solid fraction region, a laminarization phenomenon occurs and the flow and heat transfer characteristics can be estimated from the laminar flow of the hydrate slurry. Moreover, the laminarization point for the solid fraction can be predicted using the apparent Reynolds number. © 2012 Elsevier Ltd and IIR. All rights reserved.


Tanaka Y.,Tokyo University of Marine Science and Technology | Tanaka Y.,Toyo Suisan Kaisha Ltd. | Takahashi H.,Tokyo University of Marine Science and Technology | Simidu U.,Toyo Suisan Kaisha Ltd. | Kimura B.O.N.,Tokyo University of Marine Science and Technology
Journal of Food Protection | Year: 2010

A novel universal real-time PCR, consisting of newly designed oligonucleotide subsets, was designed for a bacterial housekeeping gene encoding the peptide elongation factor Tu. Specificity and universality were confirmed in 66 bacterial strains, including 51 genera and 63 species. The amplification kinetics of tuf gene-targeted real-time quantitative PCR were consistent in a wide range of bacterial species tested. A calibration curve (r2 = 0.97) was produced for the estimation of bacterial counts, based on measurements of representative inoculations with 10-fold serial dilutions of the cells of representative bacterial species. Linear regression analysis of the real-time PCR-derived bacterial counts and aerobic plate counts, in a total 149 samples consisting of 25 minced meat, 34 fresh-cut vegetables, and 90 fish, exhibited a high correlation (r2 = 0.84, 0.87, and 0.95, respectively) over the range of 3.0 to 9.0 log CFU/g. In total, the difference between the two methods was less than 0.5 log in 75 of these samples, and in the remaining 74 samples, the difference was 0.5 to 1.0 log. Presently, our tuf gene-targeted real-time quantitative PCR assay achieves a rapid (within 2 h) estimation of bacterial counts of 3.0 to 9.0 log CFU/g, in a practical manner. Copyright ©, International Association for Food Protection.


Yuichiro T.,Tokyo University of Marine Science and Technology | Yuichiro T.,Toyo Suisan Kaisha Ltd. | Hajime T.,Tokyo University of Marine Science and Technology | Nao K.,Tokyo University of Marine Science and Technology | Bon K.,Tokyo University of Marine Science and Technology
Journal of Food Protection | Year: 2010

A rapid system using terminal restriction fragment length polymorphism (T-RFLP) analysis targeting 16S rDNA is described for microbial population analysis in edible fish samples. The defined terminal restriction fragment database was constructed by collecting 102 strains of bacteria representing 53 genera that are associated with fish. Digestion of these 102 strains with two restriction enzymes, HhaI and MspI, formed 54 pattern groups with discrimination to the genus level. This T-RFLP system produced results comparable to those from a culture-based method in six natural fish samples with a qualitative correspondence of 71.4 to 92.3%. Using the T-RFLP system allowed an estimation of the microbial population within 7 h. Rapid assay of the microbial population is advantageous for food manufacturers and testing laboratories; moreover, the strategy presented here allows adaptation to specific testing applications. Copyright ©, International Association for Food Protection.


Shimojoh M.,Toyo Suisan Kaisha Ltd. | Kojima T.,Seikei University | Nakajima K.,Toyo Suisan Kaisha Ltd. | Hatta K.,Toyo Suisan Kaisha Ltd. | And 2 more authors.
Biomacromolecules | Year: 2010

In view of the interesting properties of branched polysaccharides occurring in nature, biological activities of nonnatural branched chitins having β-1,6-N-acetyl-d-glucosamine branches on the poly(β-1,4-N-acetyl-d- glucosamine) backbone have been studied. The immunostimulatory activities of the branched chitins were determined and compared with those of lentinan, a β-1,3-d-glucan having β-1,6-d-glucose branches, using the mouse macrophagelike cell line RAW264.7 in vitro. The secretions of the tumor necrosis factor and nitric oxide proved to be significantly higher with the branched chitins than with lentinan. Moreover, when interferon-- was used in conjunction with the branched chitins on macrophage treatment, a marked augmentation of nitric oxide production was observed. These results are interpreted as the direct stimulation of macrophages by the branched chitins, and the distinctive activities suggest the possibility of developing new types of polysaccharide antitumor agents. © 2010 American Chemical Society.


Patent
Toyo Suisan Kaisha Ltd. | Date: 2012-09-27

A stable Ca preparation in solution form even at high concentration is provided. The aqueous preparation of Ca includes water, Ca, compounds of Formula I and Formula II. Most of Ca is in non-ionic form and forms a complex. In the complex, Ca binds to the compound(s) of Formula I and/or Formula II in a state that basic structures of them are kept. At least partially, the complex forms colloidal particles. The aqueous preparation is transparent. pH is equal to or higher than that of slightly acid; [A_(1), A_(2), A_(3), A_(4), A_(5 )and A_(6 )are independently O^() or OX. X represents a monovalent or polyvalent cation].


Patent
Toyo Suisan Kaisha Ltd. | Date: 2011-11-23

A novel compound which specifically resides in a tumor, a method for allowing it to reside in a tumor, and a method for detecting, diagnosing, and treating tumor with use thereof are provided. The present invention relates to a compound represented by chemical formula (I)_(1) is OH, OCOH, OCO(CH_(2))_(h)CH_(3), or an acting group, h being an integer of 0 or more, R_(2) is H, OH, OCOH, OCO(CH_(2))_(i)CH_(3), or an acting group, i being an integer of 0 or more, R_(3) is OH, SO_(3)H, or an acting group, R_(4) is OH, SO_(3)H, or an acting group, and R_(5) is OH, SO_(3)H, or an acting group, at least one of R_(1), R_(2), R_(3), R_(4), and R_(5) containing an acting group, or pharmaceutically acceptable salts thereof.


Sulfoquinovosylacyl propanediol compounds represented by formula (I): wherein R_(1 )is an acyl residue of a fatty acid, Y is a number of 1, 2 or 3, and M represents a cation having a positive charge equal to Y and pharmaceutically acceptable salts thereof are effective for treating tumors.


Patent
Toyo Suisan Kaisha Ltd. | Date: 2013-02-27

A stable calcium preparation in solution form even at high concentration is provided. As such a calcium preparation, an aqueous preparation of calcium is provided, wherein the aqueous preparation of calcium includes, for example, water, calcium, a compound of Formula I, and a compound of Formula II as constituent elements, most of the calcium is in non-ionic calcium form and forms a complex, wherein in the complex, the calcium binds to the compound of Formula I and/or the compound of Formula II in a state that basic structures of these compounds are kept, at least a part of the complex forms colloidal particles, and the aqueous preparation of calcium is a transparent aqueous preparation having a pH equal to or higher than that of slightly acid;_(1), A_(2), A_(3), A_(4), A_(5) and A_(6) are independently O^(-) or OX, X represents a monovalent or polyvalent cation, and the Xs are the same or different when multiple OXs exist.


Patent
Toyo Suisan Kaisha Ltd. | Date: 2012-12-27

Provided is a dried noodle having a porosity in the cross-sectional area of the noodle of from 0.1 to 15%, a unit porosity in the cross-sectional area of the noodle of from 0.01 to 1%, a gelatinization degree of 30 to 75% and a porous structure.

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