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Tosu, Japan

Puerariae flower extract (PFE) is a crude extract of the Kudzu flower. Previous studies have shown that PFE supplementation exerts anti-obesity and anti-fatty liver effects in high-fat diet-fed mice. In this study, we aimed to identify the PFE components responsible for these effects and to determine their influence on energy expenditure and uncoupling protein 1 (UCP1) expression. Experiments were conducted on C57BL/6J male mice classified into 3 groups: (1) high-fat diet-fed (HFD), (2) high-fat diet-fed given PFE (HFD + PFE), and (3) high-fat diet-fed given the PFE isoflavone-rich fraction (HFD + ISOF). All groups were fed for 42 days. The HFD + PFE and HFD + ISOF groups showed significant resistance to increases in body weight, hepatic triglyceride level, and visceral fat compared to the HFD group. These groups also exhibited significant increases in oxygen consumption and UCP1-positive brown adipose tissue (BAT) area. Our results demonstrate that the active ingredients in PFE are present in the ISOF and that these compounds may increase energy expenditure by upregulation of BAT UCP1 expression. These findings provide valuable information regarding the anti-obesity effects of isoflavones. Source


Trademark
Toyo Shinyaku Co. | Date: 2011-05-31

Dietary supplements mainly composed of protein for medical use; dietary supplements mainly composed of protein for medical use and pharmaceuticals that act as an appetite suppressant; dietary supplements mainly composed of protein for medical use and pharmaceuticals that act as an appetite suppressant and give a feeling of satiety; dietary supplements mainly composed of protein for medical use and pharmaceuticals that give a feeling of satiety; dietary supplements mainly composed of protein and pharmaceuticals for weight loss and/or weight management and/or appetite control and/or satiety; dietary supplements mainly composed of protein for medical use and pharmaceuticals that suppress appetite by providing a feeling of satiety for the purpose of prevention and management of diabetes; nutritional additives for medical use for use in foods for human consumption; dietary cure foods mainly composed of protein, namely dietary foodstuff for medical use. Protein extracted from potato being foodstuffs for human consumption, namely, processed food stuffs mainly consisting of protein extracted from potato in the form of powder, granular, liquid, paste, cream, tablet, capsule, caplet, soft capsule, pill, bar, plate, block, pellet, solid, gel, jelly, gum, wafer, biscuit, candy, chewable, syrup and stick; protein being foodstuffs for human consumption, namely, processed food stuffs mainly consisting of protein in the form of plants, plant extract, plant fermentation extract, animal extract, green juice, Chinese herbal medicine, food fiber, or seaweed in the nature of powder, granular, liquid, paste, cream, tablet, capsule, caplet, soft capsule, pill, bar, plate, block, pellet, solid, gel, jelly, gum, wafer, biscuit, candy, chewable, syrup and stick; milk products excluding ice cream, ice milk and frozen yogurt; flakes of seasoned dried potato powder for sprinkling on rice; curry spice mixture; curry pastes; curry powder; protein for human consumption for use as a food additive; stew and soup mixes; frozen vegetables; soya milk; jelly made from devils tongue root (Konnyaku); tofu; fermented soybeans (Natto); fried tofu pieces (abura-age); freeze-dried tofu pieces (Kohri-dofu); dried flakes of laver for sprinkling on rice in hot water (Ochazuke-nori). Flour for food; potato flour; confectionery, namely, bakery goods; bread and buns; tea; processed cereals; coffee and cocoa; Chinese stuffed dumplings; sandwiches; Chinese steamed dumplings; sushi; prepared food consisting primarily of fried balls of batter mix with small pieces of octopus; steamed buns stuffed with minced meat; hamburger sandwiches; pizzas; packaged box lunch meals consisting primarily of pasta or rice; hot dog sandwiches; meat pies; ravioli; instant confectionary mixes for making fruit jellies. green juice beverages, namely, young barley leaf juices or kale juices; preparations for making green juice beverages, namely, young barley leaf powder mixes or kale powder mixes; vegetable juices; preparations for making vegetable juices; carbonated soft drinks; preparations for making carbonated soft drinks; non-alcoholic fruit juice beverages; preparations for making non-alcoholic fruit juice beverages; whey beverages; preparations for making whey beverages; beer; extracts of hops for making beer.


Trademark
Toyo Shinyaku Co. | Date: 2012-12-21

Industrial chemicals; Chemicals for use in the manufacture of cosmetic products; Chemicals for use in the manufacture of supplements; Chemicals for use in the manufacture of foods and beverages; Industrial chemicals, namely, pine bark extracts for industrial use; Polyphenol for industrial use; Proanthocyanidin for industrial use; Oligomeric proanthocyanidin for industrial use; Chemicals made from powered raw materials processed from pine bark extracts used as raw materials for foods, cosmetics, supplements; Dry powder chemicals made from pine bark extract components used as raw materials for foods, cosmetics, supplements; Industrial chemicals,namely, powdered pine bark extracts used as raw materials for foods, cosmetics, supplements; Plant growth regulating preparations; Fertilizers; Fatty acids for use in the manufacture of foods, cosmetics and food supplements; Chemical test paper; Artificial sweeteners; Flour and starch for industrial purposes. Cosmetics; Soaps and detergents. Dietary and nutritional supplements containing pine bark extracts; Dietary and nutritional supplements; Vitamin supplements. Beauty beverages, namely, soft drinks and non-alcoholic fruit juice beverages containing polyphenol or collagen; Non-alcohol beverages, namely, soft drinks and fruit juice beverages; Preparations for making beverage, namely, carbonated soft drinks, vegetable juices, non-alcoholic fruit juice beverages and whey beverages; Green juice beverages namely, young sweet potato leaf juices; Preparations for making young sweet potato leaf juices; Green juice beverages, namely, young barley leaf juices and kale juices; Preparations for making young barley leaf juices; Preparations for making kale juices.


Nakajima S.,Hokkaido University | Hira T.,Hokkaido University | Tsubata M.,Toyo Shinyaku Co. | Takagaki K.,Toyo Shinyaku Co. | Hara H.,Hokkaido University
Journal of Agricultural and Food Chemistry | Year: 2011

Dietary proteins and trypsin inhibitors are known to stimulate the secretion of the satiety hormone cholecystokinin (CCK). A potato extract (Potein) contains 60% carbohydrate and 20% protein including trypsin inhibitory proteins. In this study, we examined whether Potein suppresses food intake in rats and whether it directly stimulates CCK secretion in enteroendocrine cells. In fasted rats, food consumption was measured up to 6 h after the oral administration of Potein or soybean trypsin inhibitor (SBTI). CCK-releasing activities of Potein and SBTI were examined in the murine CCK-producing cell line STC-1. Potein inhibited the trypsin activity in vitro with a potency 20-fold lower than that of SBTI. Oral administration of Potein dose-dependently suppressed food intake for 1-6 h. Potein, but not the SBTI, dose-dependently induced CCK secretion in STC-1 cells. These results suggest that Potein suppresses food intake through the CCK secretion induced by direct stimulation on enteroendocrine cells and through inhibition of luminal trypsin. © 2011 American Chemical Society. Source


Furumura M.,Fukuoka University | Furumura M.,Kurume University | Sato N.,Fukuoka University | Kusaba N.,Toyo Shinyaku Co. | And 2 more authors.
Clinical Interventions in Aging | Year: 2012

Background: French maritime pine bark extract (PBE) has gained popularity as a dietary supplement in the treatment of various diseases due to its polyphenol-rich ingredients. Oligometric proanthocyanidins (OPCs), a class of bioflavonoid complexes, are enriched in French maritime PBE and have antioxidant and anti-inflammatory activity. Previous studies have suggested that French maritime PBE helps reduce ultraviolet radiation damage to the skin and may protect human facial skin from symptoms of photoaging. To evaluate the clinical efficacy of French maritime PBE in the improvement of photodamaged facial skin, we conducted a randomized trial of oral supplementation with PBE. Methods: One hundred and twelve women with mild to moderate photoaging of the skin were randomized to either a 12-week open trial regimen of 100 mg PBE supplementation once daily or to a parallel-group trial regimen of 40 mg PBE supplementation once daily. Results: A significant decrease in clinical grading of skin photoaging scores was observed in both time courses of 100 mg daily and 40 mg daily PBE supplementation regimens. A significant reduction in the pigmentation of age spots was also demonstrated utilizing skin color measurements. Conclusion: Clinically significant improvement in photodamaged skin could be achieved with PBE. Our findings confirm the efficacy and safety of PBE. © 2012 Furumura et al, publisher and licensee Dove Medical Press Ltd. Source

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