Toyo Shinyaku Co.

Saga-shi, Japan

Toyo Shinyaku Co.

Saga-shi, Japan
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Furumura M.,Fukuoka University | Furumura M.,Kurume University | Sato N.,Fukuoka University | Kusaba N.,Toyo Shinyaku Co Ltd | And 2 more authors.
Clinical Interventions in Aging | Year: 2012

Background: French maritime pine bark extract (PBE) has gained popularity as a dietary supplement in the treatment of various diseases due to its polyphenol-rich ingredients. Oligometric proanthocyanidins (OPCs), a class of bioflavonoid complexes, are enriched in French maritime PBE and have antioxidant and anti-inflammatory activity. Previous studies have suggested that French maritime PBE helps reduce ultraviolet radiation damage to the skin and may protect human facial skin from symptoms of photoaging. To evaluate the clinical efficacy of French maritime PBE in the improvement of photodamaged facial skin, we conducted a randomized trial of oral supplementation with PBE. Methods: One hundred and twelve women with mild to moderate photoaging of the skin were randomized to either a 12-week open trial regimen of 100 mg PBE supplementation once daily or to a parallel-group trial regimen of 40 mg PBE supplementation once daily. Results: A significant decrease in clinical grading of skin photoaging scores was observed in both time courses of 100 mg daily and 40 mg daily PBE supplementation regimens. A significant reduction in the pigmentation of age spots was also demonstrated utilizing skin color measurements. Conclusion: Clinically significant improvement in photodamaged skin could be achieved with PBE. Our findings confirm the efficacy and safety of PBE. © 2012 Furumura et al, publisher and licensee Dove Medical Press Ltd.

Yoshida A.,Kanagawa Dental College | Yoshino F.,Kanagawa Dental College | Tsubata M.,Toyo Shinyaku Co. | Ikeguchi M.,Toyo Shinyaku Co. | And 2 more authors.
Journal of Clinical Biochemistry and Nutrition | Year: 2011

Flavangenol, one of extract of French maritime pine bark, is a complex mixture of bioflavonoids with oligometric proanthocyanidins as the major constituents. These constituents, catechin and procyanidin B 1, are water-soluble derivatives of flavangenol. In this study, we investigated the antioxidant effects of flavangenol on reactive oxygen species such as hydroxyl radical, superoxide anion and singlet oxygen using electron spin resonance and spin trapping. The effect of flavangenol on oxidative stress in the skin from the maxillofacial region of hairless mice was investigated using an in vivo L-band electron spin resonance imaging system. Flavangenol attenuated oxidative stress in the maxillofacial skin by acting as a reactive oxygen species scavenger, as demonstrated by in vitro and in vivo electron spin resonance imaging analysis. The absorption and metabolism of flavangenol were also examined. After oral administration of flavangenol in human and rat, most of the catechin in plasma was in the conjugated form, while 45% to 78% of procyanidin B 1 was unconjugated, indicating that non-conjugated procyanidin B 1 would be active in the circulation. The ability of flavangenol to reduce reactive oxygen species levels in the circulation of the maxillofacial region suggests that this extract may be beneficial for skin protection from exposure to ultraviolet irradiation. ©2011 JCBN.

Nagamine R.,Toyo Shinyaku Co. | Ueno S.,Toyo Shinyaku Co. | Tsubata M.,Toyo Shinyaku Co. | Yamaguchi K.,Toyo Shinyaku Co. | And 4 more authors.
Food and Function | Year: 2014

'Suioh', a sweet potato (Ipomoea batatas L.) cultivar developed in Japan, has edible leaves and stems. The sweet potato leaves contain polyphenols such as caffeoylquinic acid (CQA) derivatives. It has multiple biological functions and may help to regulate the blood glucose concentration. In this study, we first examined whether sweet potato leaf extract powder (SP) attenuated hyperglycaemia in type 2 diabetic mice. Administration of dietary SP for 5 weeks significantly lowered glycaemia in type 2 diabetic mice. Second, we conducted in vitro experiments, and found that SP and CQA derivatives significantly enhanced glucagon-like peptide-1 (GLP-1) secretion. Third, pre-administration of SP significantly stimulated GLP-1 secretion and was accompanied by enhanced insulin secretion in rats, which resulted in a reduced glycaemic response after glucose injection. These results indicate that oral SP attenuates postprandial hyperglycaemia, possibly through enhancement of GLP-1 secretion. © the Partner Organisations 2014.

PubMed | Toyo Shinyaku Co., Harvard University and Kyushu University
Type: | Journal: Journal of thermal biology | Year: 2016

Exposure to a high ambient temperature (HT) can cause heat stress, which has a huge negative impact on physiological functions. Cellular heat-shock response is activated upon exposure to HT for cellular maintenance and adaptation. In addition, antioxidants are used to support physiological functions under HT in a variety of organisms. Flavangenol, an extract of pine bark, is one of the most potent antioxidants with its complex mixture of polyphenols. In the current study, chronic (a single daily oral administration for 14 days) or acute (a single oral administration) oral administration of flavangenol was performed on chicks. Then the chicks were exposed to an acute HT (401C for 3h) to examine the effect of flavangenol on the mRNA expression of heat-shock protein (HSP) in the brain and liver. Rectal temperature, plasma aspartate aminotransferase (AAT), a marker of liver damage, and plasma corticosterone as well as metabolites were also determined. HSP-70 and -90 mRNA expression, rectal temperature, plasma AAT and corticosterone were increased by HT. Interestingly, the chronic, but not the acute, administration of flavangenol caused a declining in the diencephalic mRNA expression of HSP-70 and -90 and plasma AAT in HT-exposed chicks. Moreover, the hepatic mRNA expression of HSP-90 was also significantly decreased by chronic oral administration of flavangenol in HT chicks. These results indicate that chronic, but not acute, oral administration of flavangenol attenuates HSP mRNA expression in the central and peripheral tissues due to its possible role in improving cellular protective functions during heat stress. The flavangenol-dependent decline in plasma AAT further suggests that liver damage induced by heat stress was minimized by flavangenol.

PubMed | Ochanomizu University and Toyo Shinyaku Co Ltd.
Type: Journal Article | Journal: Antioxidants (Basel, Switzerland) | Year: 2016

The deciduous tree Terminalia bellirica found in Southeast Asia is extensively used in traditional Indian Ayurvedic medicine for the treatment of hypertension, rheumatism, and diabetes. The anti-atherogenic effect of Terminalia bellirica fruit has not been fully elucidated. Here, we investigated the effect of Terminalia bellirica extract (TBE) on low-density lipoprotein (LDL) oxidation and inflammation in macrophages. TBE showed 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity (EC50: 7.2 1.2 g/mL) and 15-lipoxygenase inhibitory activity. TBE also significantly inhibited free radical-induced LDL oxidation compared to the solvent control in vitro. In THP-1 macrophages, TBE treatment resulted in significant decreases of the mRNA expression of tumor necrosis factor-alpha (TNF-), interleukin-1beta (IL-1), and lectin-like oxidized LDL receptor-1 (LOX-1). TBE also reduced matrix metalloproteinase (MMP)-9 secretion and intracellular reactive oxygen species (ROS) production in THP-1 macrophages. These results show that TBE has the inhibitory effects on LDL oxidation and macrophage inflammatory response in vitro, suggesting that its in vivo use might inhibit atherosclerosis plaque progression.

Nakajima S.,Hokkaido University | Hira T.,Hokkaido University | Tsubata M.,Toyo Shinyaku Company | Takagaki K.,Toyo Shinyaku Company | Hara H.,Hokkaido University
Journal of Agricultural and Food Chemistry | Year: 2011

Dietary proteins and trypsin inhibitors are known to stimulate the secretion of the satiety hormone cholecystokinin (CCK). A potato extract (Potein) contains 60% carbohydrate and 20% protein including trypsin inhibitory proteins. In this study, we examined whether Potein suppresses food intake in rats and whether it directly stimulates CCK secretion in enteroendocrine cells. In fasted rats, food consumption was measured up to 6 h after the oral administration of Potein or soybean trypsin inhibitor (SBTI). CCK-releasing activities of Potein and SBTI were examined in the murine CCK-producing cell line STC-1. Potein inhibited the trypsin activity in vitro with a potency 20-fold lower than that of SBTI. Oral administration of Potein dose-dependently suppressed food intake for 1-6 h. Potein, but not the SBTI, dose-dependently induced CCK secretion in STC-1 cells. These results suggest that Potein suppresses food intake through the CCK secretion induced by direct stimulation on enteroendocrine cells and through inhibition of luminal trypsin. © 2011 American Chemical Society.

Puerariae flower extract (PFE) is a crude extract of the Kudzu flower. Previous studies have shown that PFE supplementation exerts anti-obesity and anti-fatty liver effects in high-fat diet-fed mice. In this study, we aimed to identify the PFE components responsible for these effects and to determine their influence on energy expenditure and uncoupling protein 1 (UCP1) expression. Experiments were conducted on C57BL/6J male mice classified into 3 groups: (1) high-fat diet-fed (HFD), (2) high-fat diet-fed given PFE (HFD + PFE), and (3) high-fat diet-fed given the PFE isoflavone-rich fraction (HFD + ISOF). All groups were fed for 42 days. The HFD + PFE and HFD + ISOF groups showed significant resistance to increases in body weight, hepatic triglyceride level, and visceral fat compared to the HFD group. These groups also exhibited significant increases in oxygen consumption and UCP1-positive brown adipose tissue (BAT) area. Our results demonstrate that the active ingredients in PFE are present in the ISOF and that these compounds may increase energy expenditure by upregulation of BAT UCP1 expression. These findings provide valuable information regarding the anti-obesity effects of isoflavones.

Toyo Shinyaku Co. | Date: 2011-05-31

Dietary supplements mainly composed of protein for medical use; dietary supplements mainly composed of protein for medical use and pharmaceuticals that act as an appetite suppressant; dietary supplements mainly composed of protein for medical use and pharmaceuticals that act as an appetite suppressant and give a feeling of satiety; dietary supplements mainly composed of protein for medical use and pharmaceuticals that give a feeling of satiety; dietary supplements mainly composed of protein and pharmaceuticals for weight loss and/or weight management and/or appetite control and/or satiety; dietary supplements mainly composed of protein for medical use and pharmaceuticals that suppress appetite by providing a feeling of satiety for the purpose of prevention and management of diabetes; nutritional additives for medical use for use in foods for human consumption; dietary cure foods mainly composed of protein, namely dietary foodstuff for medical use. Protein extracted from potato being foodstuffs for human consumption, namely, processed food stuffs mainly consisting of protein extracted from potato in the form of powder, granular, liquid, paste, cream, tablet, capsule, caplet, soft capsule, pill, bar, plate, block, pellet, solid, gel, jelly, gum, wafer, biscuit, candy, chewable, syrup and stick; protein being foodstuffs for human consumption, namely, processed food stuffs mainly consisting of protein in the form of plants, plant extract, plant fermentation extract, animal extract, green juice, Chinese herbal medicine, food fiber, or seaweed in the nature of powder, granular, liquid, paste, cream, tablet, capsule, caplet, soft capsule, pill, bar, plate, block, pellet, solid, gel, jelly, gum, wafer, biscuit, candy, chewable, syrup and stick; milk products excluding ice cream, ice milk and frozen yogurt; flakes of seasoned dried potato powder for sprinkling on rice; curry spice mixture; curry pastes; curry powder; protein for human consumption for use as a food additive; stew and soup mixes; frozen vegetables; soya milk; jelly made from devils tongue root (Konnyaku); tofu; fermented soybeans (Natto); fried tofu pieces (abura-age); freeze-dried tofu pieces (Kohri-dofu); dried flakes of laver for sprinkling on rice in hot water (Ochazuke-nori). Flour for food; potato flour; confectionery, namely, bakery goods; bread and buns; tea; processed cereals; coffee and cocoa; Chinese stuffed dumplings; sandwiches; Chinese steamed dumplings; sushi; prepared food consisting primarily of fried balls of batter mix with small pieces of octopus; steamed buns stuffed with minced meat; hamburger sandwiches; pizzas; packaged box lunch meals consisting primarily of pasta or rice; hot dog sandwiches; meat pies; ravioli; instant confectionary mixes for making fruit jellies. green juice beverages, namely, young barley leaf juices or kale juices; preparations for making green juice beverages, namely, young barley leaf powder mixes or kale powder mixes; vegetable juices; preparations for making vegetable juices; carbonated soft drinks; preparations for making carbonated soft drinks; non-alcoholic fruit juice beverages; preparations for making non-alcoholic fruit juice beverages; whey beverages; preparations for making whey beverages; beer; extracts of hops for making beer.

Toyo Shinyaku Co. | Date: 2011-03-07

An alcohol metabolism enhancer is made from safe plant extracts and an alcoholic beverage and causes a reduced sick feeling and hangover from drinking alcohol without causing hemolysis using safe materials derived from plants. The alcohol metabolism enhancer and the alcoholic beverage include proanthocyanidins, such as pine bark extracts.

Toyo Shinyaku Co. | Date: 2012-12-21

Industrial chemicals; Chemicals for use in the manufacture of cosmetic products; Chemicals for use in the manufacture of supplements; Chemicals for use in the manufacture of foods and beverages; Industrial chemicals, namely, pine bark extracts for industrial use; Polyphenol for industrial use; Proanthocyanidin for industrial use; Oligomeric proanthocyanidin for industrial use; Chemicals made from powered raw materials processed from pine bark extracts used as raw materials for foods, cosmetics, supplements; Dry powder chemicals made from pine bark extract components used as raw materials for foods, cosmetics, supplements; Industrial chemicals,namely, powdered pine bark extracts used as raw materials for foods, cosmetics, supplements; Plant growth regulating preparations; Fertilizers; Fatty acids for use in the manufacture of foods, cosmetics and food supplements; Chemical test paper; Artificial sweeteners; Flour and starch for industrial purposes. Cosmetics; Soaps and detergents. Dietary and nutritional supplements containing pine bark extracts; Dietary and nutritional supplements; Vitamin supplements. Beauty beverages, namely, soft drinks and non-alcoholic fruit juice beverages containing polyphenol or collagen; Non-alcohol beverages, namely, soft drinks and fruit juice beverages; Preparations for making beverage, namely, carbonated soft drinks, vegetable juices, non-alcoholic fruit juice beverages and whey beverages; Green juice beverages namely, young sweet potato leaf juices; Preparations for making young sweet potato leaf juices; Green juice beverages, namely, young barley leaf juices and kale juices; Preparations for making young barley leaf juices; Preparations for making kale juices.

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