Toyama Chemical Co.

Toyama-shi, Japan

Toyama Chemical Co.

Toyama-shi, Japan

Time filter

Source Type

Patent
Toyama Chemical Co. | Date: 2015-02-16

Provided is a prevention or treatment agent for cerebral amyloid beta storage diseases, that contains a substance capable of suppressing the progression, alleviating the symptoms, and improving cerebral amyloid beta storage diseases. This prevention or treatment agent for cerebral amyloid beta storage diseases has as an effective component thereof a compound (e.g., Iguratimod) indicated by formula (1) or a salt thereof and, as a result, is capable of preventing or treating cerebral amyloid beta storage diseases such as Alzheimer-type dementia or cerebral amyloid angiopathy.


Provided is a medicinal composition characterized by comprising an alkyl ether derivative represented by general formula [1] [wherein: R^(1 )and R^(2 )are the same or different and represent a hydrogen atom, a halogen atom, an optionally substituted C_(1-6 )alkyl group, an optionally substituted aryl group, etc.; R^(3 )represents an optionally protected hydroxyl group, etc.; and m and n are the same or different and represent an integer of 1 to 6] or a salt thereof. The medicinal composition according to the present invention is useful as a post nerve injury rehabilitation effect-enhancing agent.


This pharmaceutical composition contains a hydroxamic acid derivative, or a salt thereof, and a solubilizer, said hydroxamic acid derivative being selected from among (2S)-2-((4-((4-((1S)-1,2-dihydroxyethyl)phenyl)ethynyl)benzoyl)(methyl)amino)-N-hydroxy-N,2-dimethylmalonamide, (2S)-2-((4-((4-((1R)-1,2-dihydroxyethyl)phenyl)ethynyl)benzoyl)(methyl)amino)-N-hydroxy-N,2-dimethylmalonamide, and (2S)-N-hydroxy-2-((4-((4-((1S)-1-hydroxy-2-methoxyethyl)phenyl)ethynyl)benzoyl)(methyl)amino)-N,2-dimethylmalonamide. The pharmaceutical composition demonstrates strong antibacterial activity, has excellent solubility in water, and is useful as a drug.


Pharmacological compositions containing a hydroxamic acid derivative selected from (2S)-2-((4-((4-((1S)-1,2-dihydroxyethyl)phenyl)ethynyl)benzoyl)(methyl)amino)-N-hydroxy-N,2-dimethylmalonamide, (2S)-2-((4-((4-((1R)-1,2-dihydroxyethyl)phenyl)ethynyl)benzoyl)(methyl)amino)-N-hydroxy-N,2-dimethylmalonamide, and (2S)-N-hydroxy-2-((4-((4-((1S)-1-hydroxy-2-methoxyethyl)phenyl)ethynyl)benzoyl)(methyl)amino)-N,2-dimethylmalonamide, or a salt of said derivatives, and an antibiotic substance are useful in the treatment of gram-negative bacterial infections.


A method for treating the relapsing-remitting or secondary progressive multiple sclerosis at the time of relapse, by administering a benzopyran derivative of the following formula or a salt thereof, where R^(1 )represents an optionally substituted C_(1-6 )alkyl group, one of R^(2 )and R^(3 )represents a hydrogen atom, and the other of R^(2 )and R^(3 )represents a hydrogen atom, an optionally substituted amino group, an optionally substituted acylamino group, an optionally substituted carbamoyl group or an optionally substituted aryl group.


A method for inhibiting macrophage migration and a method for treating neuropathic pain, by administering a benzopyran derivative of the following formula, or a salt thereof, where R represents an optionally substituted C_(1-6 )alkyl group, one of R^(2 )and R^(3 )represents a hydrogen atom, and the other of R^(2 )and R^(3 )represents a hydrogen atom, an optionally substituted amino group, an optionally substituted acylamino group, an optionally substituted carbamoyl group or an optionally substituted aryl group.


Patent
Toyama Chemical Co. | Date: 2016-01-20

A compound represented by general formula (1) (wherein R^(1) represents a hydrogen atom, an optionally substituted C_(1-6) alkyl group or the like; R^(2) represents a hydrogen atom, an optionally substituted C_(1-6) alkyl group or the like; R^(3) represents a hydrogen atom or an optionally substituted C_(1-6) alkyl group; R^(4) represents a hydrogen atom, an optionally substituted C_(1-6) alkyl group or the like; X^(1) represents an optionally substituted C_(2-6) alkynylene group or the like; A represents an optionally substituted bivalent aromatic hydrocarbon group or the like; X^(2) represents an optionally substituted C_(1-6) alkylene group or the like; Y^(1) represents an oxygen atom or the like; and R^(5) represents a hydrogen atom or the like) or a salt thereof is useful as an antibacterial agent.


Patent
Toyama Chemical Co. | Date: 2016-12-21

Provided is a prevention or treatment agent for cerebral amyloid beta storage diseases, that contains a substance capable of suppressing the progression, alleviating the symptoms, and improving cerebral amyloid beta storage diseases. This prevention or treatment agent for cerebral amyloid beta storage diseases has as an effective component thereof a compound (e.g., Iguratimod) indicated by formula (1) or a salt thereof and, as a result, is capable of preventing or treating cerebral amyloid beta storage diseases such as Alzheimer-type dementia or cerebral amyloid angiopathy.


A benzopyran derivative represented by general formula [1], or a salt thereof, is useful in therapeutic or preventive treatment of disease, wherein said therapeutic or preventive treatment is effective because said benzopyran derivative, or salt thereof, binds to MIF, has an MIF inhibitory effect, and inhibits MIF. [In the formula, R^(1) represents an optionally substituted C_(1-6) alkyl group, one of R^(2) and R^(3) represents a hydrogen atom, and the other of R^(2) and R^(3) represents a hydrogen atom, an optionally substituted amino group, an optionally substituted acylamino group, an optionally substituted carbamoyl group, or an optionally substituted aryl group.]


Provided is a medicinal composition characterized by comprising an alkyl ether derivative represented by general formula [1]^(1) and R^(2) are the same or different and represent a hydrogen atom, a halogen atom, an optionally substituted C_(1-6) alkyl group, an optionally substituted aryl group, etc.; R^(3) represents an optionally protected hydroxyl group, etc.; and m and n are the same or different and represent an integer of 1 to 6] or a salt thereof. The medicinal composition according to the present invention is useful as a post nerve injury rehabilitation effect-enhancing agent.

Loading Toyama Chemical Co. collaborators
Loading Toyama Chemical Co. collaborators