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Cáceres, Spain

De La Casa-Resino I.,Toxicology Area | Hernandez-Moreno D.,Toxicology Area | Hernandez-Moreno D.,Autonomous University of Chile | Lopez-Beceiro A.,Campus Universitario s n | And 4 more authors.
Wildlife Biology in Practice | Year: 2014

Living beings are constantly exposed to a wide variety of environmental contaminants and their biochemical response can be employed to assess the possible biological impact of such pollution. Sex can play a major role in the uptake, fate, and effects of contaminants in organisms. The present study evaluated endogenous levels of different biomarkers in liver, kidney and lung in both male and female roe deer in order to determine normal levels of these biomarkers and sex-related differences in this species. Post-mitochondrial cytochrome P450 subfamily 1A1, as well as phase II enzymes glutathione S-transferase and uridine diphospho-glucuronosyltransferase, and lipid peroxidation in terms of malondialdehyde levels were determined. The highest values of all the considered parameters were quantifed in liver. Results showed no differences by gender in levels of enzymatic activities in the three considered tissues. However, a statistical difference (P<0.05) in lipid peroxidation was observed in liver, fnding higher values in males. Nevertheless, the differences related to sex in this organ should be taken into account when the effect of pollutants has to be studied on specifc ecosystems. © 2014, I. de la Casa-Resino, D. Hernández-Moreno, A. López-Beceiro, L. Rigueira, M.P. Míguez, M. Pérez-López & L.E. Fidalgo.

Ferreiro D.,San Francisco de Asis Veterinary Hospital | Orozco J.P.,San Francisco de Asis Veterinary Hospital | Miron C.,San Francisco de Asis Veterinary Hospital | Real T.,San Francisco de Asis Veterinary Hospital | And 3 more authors.
Topics in Companion Animal Medicine | Year: 2010

This article describes a case of Chinaberry tree poisoning diagnosed in a dog. The initial clinical signs were variable and included tremors (muscular seizures) and a moderate limp in the dog's back leg, which evolved to a more severe condition in the following hours. Abdominal radiographic evaluation was requested, and abundant small, foreign, radio-dense bodies were detected, which were associated with Chinaberry tree fruits after surgical extraction. Adequate treatment was established, and the patient recovered completely. In addition, we compare clinical and gross postmortem findings in other similar cases reported in the literature. There is a general lack of information of such poisoning in pets. © 2010 Elsevier Inc. All rights reserved.

Garcia M.H.D.M.,Toxicology Area | Hernandez Moreno D.,Toxicology Area | Soler Rodriguez F.,Toxicology Area | Lopez M.P.,Toxicology Area
Journal of Environmental Science and Health - Part A Toxic/Hazardous Substances and Environmental Engineering | Year: 2011

In the present study, bioaccumulation of lead, cadmium and zinc in liver, kidney and muscle of roe deer (Capreolus capreolus) from Galicia (NW Spain) was quantified. Metal analysis was performed by Inductively Coupled Plasma Mass Spectrometry (ICP-MS). In general the quantified concentrations were associated with background environmental levels, except for Pb, where some markedly elevated concentrations were obtained, but with no toxicological relevance. The effect of sex on Cd, Pb and Zn levels was considered, females showing a general trend to accumulate higher concentrations of these metals, with the exception of the hepatic content of Cd (which was significantly higher in males, P < 0.05) and Pb levels, which did not differ according to sex. The effect of age was analysed only in male animals and was clearly observed for Pb levels, with concentrations significantly higher in adult animals (liver: P < 0.01, kidney: P < 0.05 and muscle: P < 0.001) and for Cd levels in kidney samples (P < 0.001). This study provides the first data on heavy metal content in roe deer from the area of study and suggests that this species could be a good bioindicator of metal pollution, even though both factors, sex and age, could represent an important source of variation in the bioaccumulation of these metals in wild populations. Copyright © Taylor & Francis Group, LLC.

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