Hicks J.K.,Cleveland Clinic |
Bishop J.R.,University of Minnesota |
Sangkuhl K.,Stanford University |
Muller D.J.,Campbell Family Mental Health Research Institute |
And 13 more authors.
Clinical Pharmacology and Therapeutics | Year: 2015
Selective serotonin reuptake inhibitors (SSRIs) are primary treatment options for major depressive and anxiety disorders. CYP2D6 and CYP2C19 polymorphisms can influence the metabolism of SSRIs, thereby affecting drug efficacy and safety. We summarize evidence from the published literature supporting these associations and provide dosing recommendations for fluvoxamine, paroxetine, citalopram, escitalopram, and sertraline based on CYP2D6 and/or CYP2C19 genotype (updates at www.pharmgkb.org). © 2015 American Society for Clinical Pharmacology and Therapeutics. Source