4 Town End Meadow

Grange-over-Sands, United Kingdom

4 Town End Meadow

Grange-over-Sands, United Kingdom

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Asselain B.,University Pierre and Marie Curie | Mould R.F.,4 Town End Meadow
Nowotwory | Year: 2010

The Cox proportional hazards model is one of the most well used models in the field in oncology papers: but it is also one of the least well understood statistical methodologies. This is due to although being a segment of many software packages which include survival analyses, regression models and multivariate analysis programmes, such software packages almost never give a good description of the underlying principles of this Cox model. Instead, they only give instructions on how to input data and provide standard wording to give the results. This paper describes in full the methodology of the Cox proportional hazards model. This includes an explanation of the following terms: hazard function, cumulative distribution function and survivor function.


Mould R.F.,4 Town End Meadow | Robison R.F.,2422 East Rechter Road | Van Tiggelen R.,Military Hospital
Nowotwory | Year: 2010

Louis-Frédéric Wickham and Paul-Marie Degrais, both radium martyrs, co-authored in 1909 the first textbook written exclusively for radium therapy. This was distinct from earlier textbooks on radiation therapy which relegated radium therapy to a few pages at the end of the book with the remainder devoted to the applications of X-rays. By 1906 when he became the director of the Laboratoire Biologique du Radium, the world's first Radium Institute, which was sited in the rue Artois, Paris, he was already a well known dermatologist & syphilologist working first at the Hôpital Saint-Louis and later at the Hôpital Saint-Lazare. The organisation of his Laboratoire, which was funded by the industrialist Armet de Lisle, was used as a model for many of the first radium institutes in Europe and America. After his premature death in 1913 and the upheaval of the 1914-1918 World War, Marie Curie's Institut du Radium opened in 1919. The contributions of Louis Wickham to the science & organisation of radium therapy were then overshadowed by the later achievements of the Institut du Radium in the rue d'Ulm/rue Pierre et Marie Curie. This biography describes the life & work of this remarkable physician who was selected by King George V of Great Britain as a Member of the Royal Victorian Order and was decorated in France as a Chevalier of the Légion d'Honneur. Information is also included about some of Louis Wickham's famous colleagues; Paul Degrais, Henri Dominici and Paul Oudin, as well as his son, Yves-Louis Wickham, a radiotherapist at the Institut Gustave Roussy. A complete bibliography is added.

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