Del Rosso J.Q.,JDR Dermatology Research LLC |
Del Rosso J.Q.,Touro University Nevada
Cutis | Year: 2017
Topical agents, including retinoids and antibiotics, are commonly used to treat acne vulgaris (AV) and remain as components of acne treatment guidelines. Approved topical combination formulations offer the advantages of established efficacy, decreased frequency of application, and improved convenience for patients. This article discusses both clindamycin phosphate (CP) and tretinoin (Tret) as components of a topical aqueous-based combination gel that has been shown to be effective, safe, and well tolerated for treatment of facial AV. Clinically relevant considerations with use of this treatment are also discussed, including therapeutic advantages and potential limitations. Copyright Cutis 2017.
News Article | November 24, 2016
Healthpointe is pleased to announce the addition of Dr. Hailey Dizay, D.O., to the orthopedic, surgical and sports medicine team. Dr. Dizay is fully trained in treating patients suffering from fractures, swelling, bruising, strains, sprains, and sports related injuries along with pain in the muscles, tendons and joints. She also specializes in providing treatment for patients with limited range of motion, such as an inability to straighten the back, fully raise the arm, and other movements. Dr. Hailey Dizay is a board certified Orthopedic Surgeon who specializes in arthroscopic and minimally invasive reconstructive surgery, shoulder and knee disorders and sports medicine. She received her Bachelor of Science degree with honors from the University of California, San Diego, and then received her medical degree from Touro University Nevada. She completed her Orthopedic Surgery residency through Michigan State University at Metro Health Hospital. She completed further orthopedic subspecialty training through an Orthopedic Sports Medicine and Arthroscopy fellowship at the Sports Clinic in Laguna Hills, California. Dr. Dizay also has had extensive experience caring for athletes throughout her medical career. She has been a team physician for the University of California Irvine, The Los Angeles Angels of Anaheim, Laguna Hills High School, Michigan State Athletic games, Rockford High School, and several Mixed Martial Arts, kickboxing, boxing and running events. Healthpointe’s orthopedic specialists perform surgical procedures as a last resort for complicated musculoskeletal issues. However, our orthopedists will focus on delaying surgery as much as possible in favor of less invasive treatments, such as medication and physical therapy. If these treatments are exhausted and no longer provide any relief for pain and other symptoms, surgery may then be recommend. For more information on Healthpointe’s orthopedics department, or to learn more about Dr. Dizay, please schedule an appointment through http://www.Healthpointe.net or call (800) 856-2663. Healthpointe is a leading multidisciplinary healthcare organization offering a full range of medical services in practice locations throughout Southern California (Los Angeles County, Orange County, San Bernardino County, and Riverside County). Healthpointe has locations situated in over 10 cities in Southern California including Garden Grove, which is conveniently located by Stanton, Santa Ana, Westminster, Orange, Fountain Valley, Cypress and Anaheim. As a highly regarded musculoskeletal group, we have a personal investment in the highest level of service, and we are proud of our record of excellence over the last four decades with private patients, injured workers, urgent care, personal injuries, and professional and non-professional athletes. Leading our organization is a dynamic team of healthcare professionals who continually strive to be at the forefront of medical innovation and healthcare service delivery. For more information, a complete list of services, and Healthpointe locations, visit http://www.Healthpointe.net.
Del Rosso J.Q.,Touro University Nevada |
Del Rosso J.Q.,Del Rosso Dermatology Research
Journal of Clinical and Aesthetic Dermatology | Year: 2016
Topical antifungal management of toenail onychomycosis has been fraught with several therapeutic challenges including difficulty gaining access to the site of infection and the need for prolonged durations of therapy. In addition, there has been a marked lack of information on the impact of toenail polish application on drug penetration after application. This article reviews available data from studies evaluating the effect of nail polish on antifungal drug penetration using ex vivo laboratory models with cadaver fingernail plates with both tavaborole 5% solution and efinaconazole 10% solution. In addition, changes in nail polish appearance and color transfer to applicators are also discussed, with changes noted with topical efinaconazole. Importantly, there are no data on whether or not nail polish application alters the efficacy of these topical agents.
Gaykalova D.A.,UMDNJ Robert Wood Johnson Medical School |
Nagarajavel V.,UMDNJ Robert Wood Johnson Medical School |
Bondarenko V.A.,UMDNJ Robert Wood Johnson Medical School |
Bartholomew B.,Southern Illinois University Carbondale |
And 3 more authors.
Nucleic Acids Research | Year: 2011
Many eukaryotic genes are regulated at the level of transcript elongation. Nucleosomes are likely targets for this regulation. Previously, we have shown that nucleosomes formed on very strong positioning sequences (601 and 603), present a high, orientation-dependent barrier to transcription by RNA polymerase II in vitro. The existence of this polar barrier correlates with the interaction of a 16-bp polar barrier signal (PBS) with the promoter-distal histone H3-H4 dimer. Here, we show that the polar barrier is relieved by ISW2, an ATP-dependent chromatin remodeler, which translocates the nucleosome over a short distance, such that the PBS no longer interacts with the distal H3-H4 dimer, although it remains within the nucleosome. In vivo, insertion of the 603 positioning sequence into the yeast CUP1 gene results in a modest reduction in transcription, but this reduction is orientation-independent, indicating that the polar barrier can be circumvented. However, the 603-nucleosome is present at the expected position in only a small fraction of cells. Thus, the polar barrier is probably non-functional in vivo because the nucleosome is not positioned appropriately, presumably due to nucleosome sliding activities. We suggest that interactions between PBSs and chromatin remodelers might have significant regulatory potential. © 2011 The Author(s).
Rempfer M.,University of Missouri - Kansas City |
Brown C.,Touro University Nevada |
Hamera E.,University of Kansas Medical Center
Psychiatry Research | Year: 2011
Twenty-five individuals with serious mental illness completed a grocery shopping skills intervention and a test-train-test version of the Wisconsin Card Sorting Test (WCST), which yielded indices of static performance and learning potential. WCST learning potential predicted skill acquisition beyond the static index of traditional WCST performance. © 2010 Elsevier Ltd.
Zayat E.,Rockhurst University |
Rempfer M.,University of Missouri - Kansas City |
Gajewski B.,University of Kansas Medical Center |
Brown C.E.,Touro University Nevada
Psychiatry Research | Year: 2011
This study examined the relationships between a set of real-world performance measures and a set of executive function measures with a sample of community based individuals with schizophrenia (N=80). Participants were given a battery of cognitive tests and were evaluated with a real-world performance measure, the Test of Grocery Shopping Skills (TOGSS). Using canonical correlation analysis, executive functions of planning, problem solving, working memory, and task persistence were significantly related to grocery shopping efficiency and accuracy. Two canonical variates with moderate correlations (0.547 and 0.519) explain that 30% of the variance in the executive function and grocery shopping measures was shared. These results identify patterns of association between executive function performance and the independent living skill of grocery shopping indicating the Test of Grocery Shopping Skills may be considered a sensitive measure of executive function performance in a real-world setting. © 2010 Elsevier Ltd.
Lee H.,Loma Linda University |
Petrofsky J.S.,Loma Linda University |
Daher N.,Loma Linda University |
Berk L.,Loma Linda University |
And 2 more authors.
European Journal of Applied Physiology | Year: 2014
Eighty-two percent of sexually active women aged 15-44 have used oral contraceptive pills (OCP) in the United States. The OCP, an exogenous source of synthetic forms of steroid hormones, prevents ovulation. Hormone changes during the menstrual cycle (MC) are believed to have an impact on anterior cruciate ligament (ACL) laxity due to estrogen. Because the estrogen receptor β resides on human connective tissue, OCP may have potential impact on tendon and ligament synthesis, structure, and biomechanical properties. Temperature has also been known to have an effect on tissue elasticity. Therefore, the purpose of this study was to investigate the differences in ACL elasticity, force to flex the knee (FFK), and knee flexion-extension hysteresis (KFEH) between OCP users and non-OCP users. To investigate these changes, two different knee temperatures were measured. Nineteen young females were divided into two groups: OCP users and non-OCP users. Blood for estradiol serum concentration (E2) was taken before beginning the tests. ACL elasticity, FFK, and KFEH were assessed both at ambient temperature (22 C) and after 38 C warming of the leg to stabilize tissue temperature. Assessments were performed four times during the MC. Throughout the MC, ACL elasticity, FFK, and KFEH fluctuated in non-OCP users, but not in OCP users. At ambient temperature, ACL elasticity was significantly lower and FFK and KFEH were significantly higher in OCP users than non-OCP users (p < 0.05). But, no significant differences in FFK and KFEH between the two groups were found after warming to 38 C. © 2013 Springer-Verlag Berlin Heidelberg.
Daughton C.G.,U.S. Environmental Protection Agency |
Ruhoy I.S.,Touro University Nevada |
Ruhoy I.S.,University of Washington
Expert Review of Clinical Pharmacology | Year: 2011
Active pharmaceutical ingredients (APIs) are ubiquitous environmental contaminants, resulting primarily from excretion and bathing and from disposal of leftover drugs by consumers and healthcare facilities. Although prudent disposal of leftover drugs has attracted the most attention for reducing API levels in the aquatic environment, a more effective approach would prevent the generation of leftover drugs in the first place. Many aspects of the practice of medicine and pharmacy can be targeted for reducing environmental contamination by APIs. These same modifications - focused on treating humans and the environment as a single, integral patient - could also have collateral outcomes with improved therapeutic outcomes, and with a reduced incidence of unintended poisonings, drug interactions and drug diversion, and lower consumer costs. © 2011 Expert Reviews Ltd.
Miller B.R.,Valley Hospital Medical Center |
Nguyen H.,Valley Hospital Medical Center |
Hu C.J.-H.,Valley Hospital Medical Center |
Lin C.,Valley Hospital Medical Center |
Nguyen Q.T.,Touro University Nevada
American Health and Drug Benefits | Year: 2014
BACKGROUND: Diabetes is a deadly and costly disease. The number of adults in the United States with newly diagnosed diabetes has nearly tripled from 1980 to 2011. At the current pace, 1 in 3 US adults will have diabetes in their lifetime. Currently, 14 classes of drugs are available to treat type 2 diabetes mellitus, but only 36% of patients with type 2 diabetes achieve glycemic control with the currently available therapies. Therefore, new treatment options are desperately needed.DISCUSSION: Despite the availability of many pharmacotherapies, in 2011 an estimated 3.1 million (14.9%) patients with type 2 diabetes still reported not taking medications to treat their diabetes. Patient compliance is a major obstacle facing practicing clinicians on a daily basis. New treatment options are desperately needed, but efficacy and tolerability are no longer the only criteria contributing to the success of a drug. Ease of administration, convenient dosing frequency, being weight control friendly, and having a low risk for hypoglycemia are important factors for the survival of a new drug in the US healthcare system. The present review is focused on important new drugs and drug classes in the pipeline, as well as on recently approved drugs, including sodium glucose cotransporter-2 inhibitors, glucagon-like peptide-1 agents, and new insulin therapies, as well as on the technologic improvements in the delivery and dosing frequency of some of the currently available drugs.CONCLUSIONS: In the United States, diabetes can be expected to continue to wreak significant human and financial tolls. The associated complications will continue to climb if they are not controlled and stopped. New therapies for diabetes are clearly needed that will better address these unmet needs. The common threads among the emerging therapies are their convenience of administration and dosing frequency, which are important to the improvement of patient adherence. © 2014, Engage Healthcare Communications, Inc. All rights reserved.
Rosso J.Q.D.,Touro University Nevada |
Rosso J.Q.D.,Del Rosso Dermatology Research Center
Journal of Clinical and Aesthetic Dermatology | Year: 2016
Polypodium leucotomas extract is a natural product derived from a tropical fern that is available as an over-Thecounter product in the United States and several other countries. A designated brand of oral Polypodium leucotomas extract has been shown in several research studies to exhibit a variety of antioxidant and photoprotective properties. Clinical research with this same formulation of Polypodium leucotomas extract has demonstrated multiple potential therapeutic applications. This article provides a thorough overview of research completed with Polypodium leucotomas extract and outlines suggested approaches for clinical use.