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Bethel Island, CA, United States

Lundgren J.D.,University of Missouri - Kansas City | Rempfer M.V.,University of Missouri - Kansas City | Brown C.E.,Touro University | Brown C.E.,University of Kansas Medical Center | And 2 more authors.
Psychiatry Research | Year: 2010

The prevalence of night eating syndrome (NES) and binge eating disorder (BED) was assessed among overweight and obese, weight-loss-seeking individuals with serious mental illness (SMI). Sixty-eight consecutive overweight (BMI ≥ 25 kg/m2) and obese (BMI ≥ 30 kg/m2) individuals with SMI (mean age=43.9 years; mean BMI = 37.2 kg/2; 67.6% Caucasian, 60.3% female) who were enrolled in a group behavioral weight loss treatment program were assessed at baseline for NES and BED with clinician-administered diagnostic interviews. Using conservative criteria, 25.0% met criteria for NES, 5.9% met criteria for BED, and only one participant met criteria for both NES and BED. This is the first study to find that obese individuals with SMI, compared with previously studied populations, are at significantly greater risk for NES, but are not at greater risk for BED. Stress, sleep, and medication use might account for the high prevalence of NES found in this population. © 2008 Elsevier Ireland Ltd. All rights reserved. Source

Watson T.S.,Desert Orthopaedic Center | Shurnas P.S.,Columbia Orthopaedic Group | Denker J.,Touro University
Journal of the American Academy of Orthopaedic Surgeons | Year: 2010

Injuries to the tarsometatarsal joint complex, also known as the Lisfranc joint, are relatively uncommon. However, the importance of an accurate diagnosis cannot be overstated. These injuries, especially when missed, may result in considerable long-term disability as the result of posttraumatic arthritis. A high level of suspicion, recognition of the clinical signs of injury, and appropriate radiographic studies are needed for correct diagnosis. When surgery is indicated, closed reduction with percutaneous screw fixation should be attempted. If reduction is questionable, open reduction should be performed. Screw fixation remains the traditional fixation technique. Copyright 2010 by the American Academy of Orthopaedic Surgeons. Source

Jordan D.N.,University of California at Los Angeles | Jordan D.N.,California State University, Fullerton | Jordan J.L.,Touro University
Journal of Diabetes and its Complications | Year: 2010

Aim: To examine the diabetes self-care behaviors of Filipino-American (FA) adults with type 2 diabetes mellitus (DM). Method: The Summary of Diabetes Self Care Activities-Revised and Expanded measure was administered to 192 (74 males and 118 females) FA adult immigrants with type 2 DM. Results: Older FAs (≥65 years), females, those who were older when they immigrated, and participants diagnosed with type 2 DM longer were more likely to follow recommended medication regimens. Younger FAs (<65 years) and participants diagnosed with type 2 DM for shorter duration of time were less likely to perform blood glucose testing. Most FAs reported following their eating plans; however, those who lived in the United States (US) longer followed healthful eating plans. Likewise, females reported eating five or more servings of fruits and/or vegetables daily. Moreover, older FAs reported evenly spacing carbohydrate intake everyday. Furthermore, older participants, those with less education, participants who were older when they immigrated, and those older when diagnosed with type 2 DM ate fewer foods high in fats. As to physical activity, FA males and participants with higher education exercised more frequently. Conclusion: Younger FAs were less likely to perform optimum type 2 DM self-care behaviors pertaining to diet, medication taking, and blood glucose testing compared to their older counterparts. This finding suggests an increased risk for type 2 DM comorbidities and/or complications in younger FAs, which may require more intensive treatments in later years. © 2010. Source

Rao M.N.,San Francisco Veterans Affairs Medical Center | Rao M.N.,University of California at San Francisco | Neylan T.C.,San Francisco Veterans Affairs Medical Center | Neylan T.C.,University of California at San Francisco | And 6 more authors.
Journal of Clinical Endocrinology and Metabolism | Year: 2015

Context: Short sleep duration is associated with an increased risk of type 2 diabetes. Subchronic sleep restriction (SR) causes insulin resistance, but the mechanisms and roles of specific tissues are unclear. Objective: The purpose of this article was to determine whether subchronic SR altered (1) hepatic insulin sensitivity, (2) peripheral insulin sensitivity, and (3) substrate utilization. Design: This was a randomized crossover study in which 14 subjects underwent 2 admissions separated by a washout period. Each admission had 2 acclimatization nights followed by 5 nights of either SR (4 hours time in bed) or normal sleep (8 hours time in bed). Main Outcome Measure/Methods: Insulin sensitivity (measured by hyperinsulinemic-euglycemic clamp) and hepatic insulin sensitivity (measured by stable isotope techniques) were measured. In addition, we assayed stress hormone (24-hour urine free cortisol, metanephrine, and normetanephrine), nonesterified fatty acid (NEFA), and β-hydroxybutyrate (β-OH butyrate) levels. Resting energy expenditure (REE) and respiratory quotient (RQ) were measured by indirect calorimetry. Results: Comparedto normal sleep, whole-body insulin sensitivity decreased by25%(P=.008) with SRandperipheral insulin sensitivity decreased by29%(P=.003). Whereas hepatic insulin sensitivity (endogenous glucose production) did not change significantly, percent gluconeogenesis increased (P =.03). Stress hormones increased modestly (cortisol by 21%, P =.04; metanephrine by 8%, P =.014; normetanephrine by 18%, P =.002). Fasting NEFA and =-OH butyrate levels increased substantially (62% and 55%, respectively). REE did not change (P=0.98), but RQ decreased (0.81 =.02 vs 0.75±0.02, P =.045). Conclusion: Subchronic SR causes unique metabolic disturbances characterized by peripheral, but not hepatic, insulin resistance; this was associated with a robust increase in fasting NEFA levels (indicative of increased lipolysis), decreased RQ, and increased =-OH butyrate levels (indicative of whole-body and hepatic fat oxidation, respectively). We postulate that elevated NEFA levels are partially responsible for the decrease in peripheral sensitivity and modulation of hepatic metabolism (ie, increase in gluconeogenesis without increase in endogenous glucose production). Elevated cortisol and metanephrine levels may contribute to insulin resistance by increasing lipolysis and NEFA levels. Copyright © 2015 by the Endocrine Society. Source

Touro University | Date: 2011-01-14

A new series of HIV-1 fusion inhibitors and methods of use are disclosed. The compounds are based on a substituted indole, benzimidazole, indoline or isoindoline fragment. The compounds find use in inhibiting or preventing HIV fusion from occurring, thus inhibiting or preventing entry of viral RNA into host cells. The compounds may be useful towards other biological targets involving protein-protein interactions.

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