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Toulouse, France

Toulouse 1 University Capitole is located in the heart of the city of Toulouse, in southwestern France. Wikipedia.

Toulouse 1 University Capitole | Date: 2015-04-23

The present invention relates to a method for assessing a subjects risk of having a cardiovascular disease comprising the step of measuring the level of IF1 in a body fluid sample obtained from said subject wherein the level of EF1 is negatively correlated with the risk of said subject of having cardiovascular disease.

Colin S.,Toulouse 1 University Capitole
Journal of Heat Transfer | Year: 2012

Accurate modeling of gas microvection is crucial for a lot of MEMS applications (microheat exchangers, pressure gauges, fluidic microactuators for active control of aerodynamic flows, mass flow and temperature microsensors, micropumps, and microsystems for mixing or separation for local gas analysis, mass spectrometers, vacuum, and dosing valves). Gas flows in microsystems are often in the slip flow regime, characterized by a moderate rarefaction with a Knudsen number of the order of 10 -2-10 -1. In this regime, velocity slip and temperature jump at the walls play a major role in heat transfer. This paper presents a state of the art review on convective heat transfer in microchannels, focusing on rarefaction effects in the slip flow regime. Analytical and numerical models are compared for various microchannel geometries and heat transfer conditions (constant heat flux or constant wall temperature). The validity of simplifying assumptions is detailed and the role played by the kind of velocity slip and temperature jump boundary conditions is shown. The influence of specific effects, such as viscous dissipation, axial conduction and variable fluid properties is also discussed. Source

VanRullen R.,Toulouse 1 University Capitole
Philosophical transactions of the Royal Society of London. Series B, Biological sciences | Year: 2014

Does our perceptual awareness consist of a continuous stream, or a discrete sequence of perceptual cycles, possibly associated with the rhythmic structure of brain activity? This has been a long-standing question in neuroscience. We review recent psychophysical and electrophysiological studies indicating that part of our visual awareness proceeds in approximately 7-13 Hz cycles rather than continuously. On the other hand, experimental attempts at applying similar tools to demonstrate the discreteness of auditory awareness have been largely unsuccessful. We argue and demonstrate experimentally that visual and auditory perception are not equally affected by temporal subsampling of their respective input streams: video sequences remain intelligible at sampling rates of two to three frames per second, whereas audio inputs lose their fine temporal structure, and thus all significance, below 20-30 samples per second. This does not mean, however, that our auditory perception must proceed continuously. Instead, we propose that audition could still involve perceptual cycles, but the periodic sampling should happen only after the stage of auditory feature extraction. In addition, although visual perceptual cycles can follow one another at a spontaneous pace largely independent of the visual input, auditory cycles may need to sample the input stream more flexibly, by adapting to the temporal structure of the auditory inputs. Source

In acute myeloid leukemia (AML), new strategies assess the potential benefit of genetically targeted therapy at diagnosis. This implies waiting for laboratory tests and therefore a delay in initiation of chemotherapy. We studied the impact of time from diagnosis to treatment (TDT) on overall survival, early death, and response rate in a retrospective series of 599 newly diagnosed AML patients treated by induction chemotherapy between 2000 and 2009. The effect of TDT was assessed using multivariate analysis. TDT was analyzed as a continuous variable using a specific polynomial function to model the shape and form of the relationship. The median TDT was 8 days (interquartile range, 4-16) and was significantly longer in patients with a white blood cell count (WBC) <50 Giga per liter (G/L) (P < .0001) and in older patients (P = .0004). In multivariate analysis, TDT had no impact on overall survival (P = .4095) compared with age >60 years, secondary AML, WBC >50 G/L, European LeukemiaNet risk groups, and Eastern Cooperative Oncology Group performance status. Furthermore, TDT was not associated with response rate and early death. Thus, waiting a short period of time for laboratory tests to characterize leukemias better and design adapted therapeutic strategies at diagnosis seems possible. Source

Pitie M.,CNRS Coordination Chemistry | Pratviel G.,Toulouse 1 University Capitole
Chemical Reviews | Year: 2010

A study was conducted to demonstrate activation of DNA carbon-hydrogen bonds by metal complexes. It was demonstrated that active species, formed by activation of O 2 or H 2O 2 with metal complexes was divided into three categories. The most commonly used metals in the field of oxygen activation and DNA damage were iron, copper, and manganese. It was also demonstrated that a triple helix strategy was necessary when sequence selective oxidation of a DNA duplex target was desired. Proteins were found to be alternative macromolecules that were able to selectively target large DNA sequences apart from oligonucleotides. A final strategy for targeting a metal complex to bind DNA consisted of the preparation of conjugates with agents able to form a covalent linkage with DNA. Source

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