National University Corporation Tottori University , abbreviated to Toridai , is a national university in Japan. The main campus is located in Koyamachō-Minami, Tottori City, Tottori Prefecture. Another campus, the Faculty of Medicine, is located on the Yonago Campus in Yonago, Tottori. Wikipedia.
Tottori University and Chest M.I. Incorporated | Date: 2017-09-06
A testing instrument (10) is configured by coupling a pipe (12), a cover (13), a filter member (14), and a detector (15). These members each have a hollow shape, and a series of pipe portion is configured by coupling them to each other. The pipe (12) has a plurality of holes penetrating the pipe (12) from the outer surface to the inner surface. The cover (13) covers these holes and guides a reagent to the holes from an inflow port. An inhalation tool (11) to be held in the mouth of a subject is installed on the pipe (12) in a detachable manner. A reagent gas mixture is supplied to the cover (13) from a reagent supply unit (20). Inhalation of the reagent induces the subject to cough, and airflow generated by the cough flows through the pipe portion. The detector (15) detects strength of the airflow flowing through the pipe portion and outputs a detection signal to a measuring unit (30).
Tottori University | Date: 2017-04-05
A novel therapeutic drug for malignant tumors, cancer stem cells, or fibrosis is obtained. A therapeutic drug for malignant tumors or cancer stem cells is used that includes at least one compound selected from the group consisting of compounds represented by formulas (1), (2), and (5), a salt thereof, or a solvate thereof. Alternatively, a therapeutic drug for fibrosis can be used that includes at least one compound selected from the group consisting of compounds represented by formulas (1), (2), and (5), a salt thereof, or a solvate thereof.
Iluka College Co. and Tottori University | Date: 2015-02-25
Provided is a dropping-type fire extinguishing body that, in fire extinguishing using a gel-like fire extinguishing agent, can allow the fire extinguishing agent to be smoothly conveyed and dropped. A dropping-type fire extinguishing body 1 to be dropped onto the fire site to extinguish the fire, wherein a gelling agent 3 is contained in a bag body 2 formed of a water-permeable material and water is permeated into the body and is mixed with the gelling agent to prepare a gel-like fire extinguishing agent, thereby filling the gel-like fire extinguishing agent into the inside of the bag body.
Tottori University and The University of Shimane | Date: 2017-01-25
This internal pressure loading system includes an internal pressure loading device and an information processing device. The internal pressure loading device is set at an inner face of a pipe, and includes a load meter which detects the load applied to the inner face of the pipe and a displacement meter which detects the deformation amount of the pipe. When the internal pressure loading device is expanded so as to increase the load to be detected by the load meter, the width of the pipe at which the displacement meter is located is reduced. On the basis of the load detected by the load meter and the deformation amount detected by the displacement meter, the information processing device evaluates the remaining strength of the pipe.
Wohleb E.S.,Yale University |
Franklin T.,Yale University |
Iwata M.,Tottori University |
Duman R.S.,Yale University
Nature Reviews Neuroscience | Year: 2016
Data from clinical and preclinical studies indicate that immune dysregulation, specifically of inflammatory processes, is associated with symptoms of major depressive disorder (MDD). In particular, increased levels of circulating pro-inflammatory cytokines and concomitant activation of brain-resident microglia can lead to depressive behavioural symptoms. Repeated exposure to psychological stress has a profound impact on peripheral immune responses and perturbs the function of brain microglia, which may contribute to neurobiological changes underlying MDD. Here, we review these findings and discuss ongoing studies examining neuroimmune mechanisms that influence neuronal activity as well as synaptic plasticity. Interventions targeting immune-related cellular and molecular pathways may benefit subsets of MDD patients with immune dysregulation. © 2016 Macmillan Publishers Limited.
Daio and Tottori University | Date: 2016-11-02
To know an absorption and diffusion state with time of drainage. In a state in which an absorbent article 2 is put on a human body type dummy doll 20 equipped with a body fluid-supplying means, the absorbent article 2 is photographed after the fluid is excreted from the dummy doll 20 by an X-ray CT apparatus 1; and at least one absorption modes of absorption modes of the drainage into the absorbent article 2 after the excretion in the state in which the absorbent article 2 is put on the dummy doll 20, and absorption dynamics of the drainage on the absorbent article 2 after the excretion is displayed/analyzed based on the photographed image.
Daio and Tottori University | Date: 2016-11-02
The present invention aims at providing a disposable diaper having excellent maintainability of a surface space and capable of being easily produced. It is characterized in that a lower layer absorbent body (23B) has, at least at center of a crotch portion (C2) in a width direction, an elongated lower layer through section (60) piercing in a thickness direction and extending in a front-back direction; an upper layer absorbent body (23A) has an upper layer through section (50) piercing in the thickness direction at least within a range corresponding to the lower layer through section (60) in the front-back direction, the upper layer through section (50) has an elongated middle section (51) extending in the front-back direction so as to be located above the lower layer through section (60), and extending sections (52) which extend, in the width direction, from both sides of a back side position of the middle section (51), and a side edge of the extending section (52) has a shape in which at least a part of the front side thereof is located further outside in the width direction toward the back side.
Kuwamoto S.,Tottori University
Human Pathology | Year: 2011
Recent outstanding research has rapidly revealed new aspects of the biology, etiology, and clinicopathology of Merkel cell carcinoma, a rare but highly aggressive neuroendocrine skin malignancy that affects the elderly and immunosuppressed patients. Molecular biological studies, especially the discovery of Merkel cell polyomavirus, have shed new light on the pathogenesis of the disease. Increasing evidence strongly suggests that this virus is causally related to the development of Merkel cell carcinoma. On the other hand, many studies have also indicated that a subset (approximately 20%) of Merkel cell carcinomas are not likely to be associated with the virus. Tumors with and without the virus have been shown to be significantly different in prognosis, oncogene expression, and histologic appearance, suggesting that they have different etiologies. Moreover, studies on the histopathology, immunohistochemistry, and cytogenetics have revealed several biological factors that are related to the clinical behavior and prognosis of the disease. This review summarizes the advances in the molecular biology of Merkel cell carcinoma based on recent study results. Although the exact molecular pathway of the pathogenesis of Merkel cell carcinoma remains unclear, further understanding of the pathophysiology of this tumor is expected to result in novel therapeutic approaches for management of the disease and contribute to better patient outcomes. © 2011 Elsevier Inc. All rights reserved.
Tottori University | Date: 2015-08-26
It is an object of the present invention to evaluate the induction of a drug-metabolizing enzyme by a test substance more accurately than ever before, by simple operations, using a vector in which a reporter gene is connected downstream of the expression control region of a drug-metabolizing enzyme gene and a cell into which the aforementioned vector is introduced. The present invention provides a vector for producing a cell that is used for evaluation of the induction of a drug-metabolizing enzyme by a test substance and the cytotoxicity of the test substance, the vector comprising an expression control region of a fetus-specific gene, a first reporter gene, an expression control region of a drug-metabolizing enzyme gene, and a second reporter gene, wherein the first reporter gene is located downstream of the expression control region of the fetus-specific gene and the second reporter gene is located downstream of the expression control region of the drug-metabolizing enzyme gene. In addition, the present invention also provides a cell comprising the aforementioned vector and a method for evaluating induction of a drug-metabolizing enzyme by a test substance and cytotoxicity of the test substance using the vector.
Tottori University and The Chemo Sero Therapeutic Research Institute | Date: 2016-09-28
This invention provides a vaccinia virus that grows specifically in a cancer cell and damages such cancer cell and the use of such virus for treatment of cancer. Such mitogen-activated protein kinase-dependent vaccinia virus strain lacks functions of vaccinia virus growth factor (VGF) and O1L, it does not grow in normal cells but grows specifically in cancer cells, and it has oncolytic properties that specifically damage cancer cells.