Masago T.,Tottori Medical Center |
Nemoto R.,Tottori Medical Center
Nishinihon Journal of Urology | Year: 2011
The patient was a 68-year -old man with the chief complaint of macrohematuria and urgency. Cystoscopy enabled us to recognize a non-papillary broad-based tumor within the bladder. The histopathological findings of the TUR-biopsy specimen demonstrated small cell carcinoma In another hospital, the patient underwent neoaduvant therapy and then total cystectomy with cutaneous ureterostomy. Seven months after the operation, abdominal CT scan showed lymph node swelling of the right hilum of the lung and bifurcation of the trachea, in addition to right adrenal gland swelling. We performed four courses of combined chemotherapy comprising etoposide (VP-16) plus cisplatin (CDDP) followed by PR. The patient currently remains alive without disease in February 2010.
Tanaka K.,Tottori Prefectural Central Hospital |
Nakayasu H.,Tottori Prefectural Central Hospital |
Suto Y.,Tottori Prefectural Central Hospital |
Takahashi S.,Tottori Prefectural Central Hospital |
And 5 more authors.
Internal Medicine | Year: 2016
A patient with xerostomia and xerophthalmia due to Sjögren’s syndrome presented with acute motordominant polyneuropathy and multiple mononeuropathy with antiganglioside antibodies. Nerve conduction studies and a sural nerve biopsy revealed the neuropathy as a mixture of segmental demyelination and axonal degeneration. Positive results were obtained for several antiganglioside antibodies. Corticosteroid treatment proved effective. The neuropathy was considered to represent a mixture of polyneuropathy as Guillain-Barré syndrome and multiple mononeuropathy via Sjögren’s syndrome. We speculate that Guillain-Barré syndrome occurred in the patient and Guillain-Barré syndrome itself activated multiple mononeuropathy via Sjögren’s syndrome. © 2016 The Japanese Society of Internal Medicine.
PubMed | Tottori Medical Center
Type: Journal Article | Journal: Tottori Rinsho Kagaku Kenkyukai shi | Year: 2012
It is likely that neuroinflammation begins well before detectable cognitive impairment in Alzheimers disease (AD) occurs. Clarifying the alterations occurring prior to the clinical manifestation of overt AD dementia may provide valuable insight into the early diagnosis and management of AD. Herein, to address the issue that neuroinflammation precedes development of AD pathology, we analyzed cytokine expression profiles of the brain, with focus on non-demented control patients with increasing AD pathology, referred to as high pathology control (HPC) cases, who provide an intermediate subset between AD and normal control cases referred to as low pathology control (LPC) cases. With a semi-quantitative analysis of cytokine mRNA, among 15 cytokines and their related molecules tested, we found the involvement of eight: interleukin-1(IL-1) receptor antagonist (IL-1ra), IL-1 converting enzyme (ICE), IL-2, IL-6, IL-8, tumor necrosis factor (TNF) , macrophage-colony stimulating factor (M-CSF) and transforming growth factor (TGF) 1 during the development from LPC to HPC, while decreases in IL-1ra, IL-8, MCP-1 and TNF, and an increase in TACE were implicated in the later development from HPC to AD. These findings indicate that neuroinflammation precedes the clinical manifestation of overt dementia, rather than being involved at the later stages of AD.