Hernandez-Cortes P.,University of Granada |
Pajares-Lopez M.,University of Granada |
Robles-Molina M.J.,University of Granada |
Gomez-Sanchez R.,University of Granada |
And 2 more authors.
Journal of Hand Surgery: European Volume | Year: 2012
The aim of this study was to evaluate clinical and radiographic outcomes of Elektra trapeziometacarpal prostheses after 2 years. We present a longitudinal cohort study of 19 prostheses for the treatment of Eaton stage II and III osteoarthritis (mean follow-up of 29 months). QuickDASH score, pinch strength and mobility were determined, and radiographs were analysed. Isotope scans were taken in patients with persistent pain or suspected loosening. Although the QuickDASH score was 69 before and 38 after surgery, nine patients had pain at the trapeziometacarpal joint with radiographic osteolysis around the trapezium component and a positive bone scan uptake at subsequent follow-up. The implant was revised in three of these nine patients and another patient underwent surgery for periprosthetic fracture. Only ten of the 19 implants showed no sign of failure. Most problems derived from the trapezium cup. Because of these poor outcomes after only 2 years, we cannot recommend this implant. © The British Society for Surgery of the Hand 2011.
Rosas K.,Torrecardenas Hospital |
Parron I.,University of Almeria |
Serrano P.,Torrecardenas Hospital |
Cimadevilla J.M.,University of Almeria
Epilepsy and Behavior | Year: 2013
Temporal lobe epilepsy is often resistant to medical management. Patients experience seizures for years until they receive surgical interventions. During that time, they can exhibit an altered cognition that can be assessed using virtual reality-based neuropsychological tasks. In this study, we coupled a recognition task with a spatial learning task to assess spatial learning and spatial recognition in patients with pharmacoresistant epilepsy. We tested spatial learning and spatial recognition in 8 subjects with epilepsy and 8 control subjects. Tests were based on virtual reality technologies. Data collected showed that groups did not differ in spatial learning, but recognition was better in the control group. They showed a shorter reaction time and fewer errors. This supports the hippocampal role in managing an allothetic environment representation and suggests that the spatial recognition task can be very sensitive to hippocampal disturbances. © 2013 Elsevier Inc.
Cazorla-Reyes R.,University of Almeria |
Romero-Gonzalez R.,University of Almeria |
Frenich A.G.,University of Almeria |
Rodriguez Maresca M.A.,Torrecardenas Hospital |
Martinez Vidal J.L.,University of Almeria
Journal of Pharmaceutical and Biomedical Analysis | Year: 2014
A rapid and reliable multiclass method was developed for the simultaneous analysis of 21 antibiotics (beta-lactams, aminoglycosides, penicillins, cephalosporins, carbapenems or quinolones) in urine, serum, cerebrospinal fluid (CSF) and bronchial aspirations by ultra-high performance liquid chromatography coupled to tandem mass spectrometry (UHPLC-MS/MS). Prior to chromatographic determination, the analytes were extracted from human biological fluids by simple sample treatments, which imply dilution, liquefaction, or protein precipitation. Several chromatographic conditions were optimized in order to obtain a fast separation (<6. min for each chromatographic run). MS/MS conditions were evaluated in order to increase selectivity and sensitivity and all compounds were detected in electrospray (ESI) positive ion mode, except clavulanic acid and sulbactam, which were monitored in negative ion mode. The developed method was validated in terms of linearity, selectivity, limits of detection (LODs) and quantification (LOQs), trueness, repeatability and interday precision. The LOQs ranged from 0.01 to 1.00. mg/L for urine, serum and CSF. In case of bronchial aspirations, the LOQs were between 0.02 and 0.67. mg/kg. In all matrices the recovery results were in the range 70-120% and interday precision was lower than 25%. Finally, the optimized method was applied to the analysis of biological samples from 10 patients in the intensive care unit (ICU) of a hospital located in Almeria (Spain). Several antibiotics (e.g., amoxicillin, tobramycin, levofloxacin, or linezolid) were found in the studied samples, observing that the highest concentrations were obtained in urine samples. © 2013 Elsevier B.V.
Canovas R.,University of Almeria |
Leon I.,University of Almeria |
Serrano P.,Torrecardenas Hospital |
Roldan M.D.,University of Almeria |
Cimadevilla J.M.,University of Almeria
Epilepsy and Behavior | Year: 2011
This study was aimed at examining spatial learning and memory in nonoperated temporal lobe epilepsy (TLE). Twenty-five patients with a refractory epileptic focus located in the temporal lobe (10 in the right hemisphere and 15 in the left hemisphere) and 25 healthy age-matched controls performed the "Boxes Room," a virtual reality version of the holeboard. They were trained in 10 trials to locate the reward boxes in a room with 16 of them available. Participants also completed a comprehensive neuropsychological evaluation. Patients performed significantly worse relative to the control group. They traveled longer distances and committed more errors than controls. No differences in performance were found within the TLE group when gender or lateralization of the epileptic focus was considered an independent variable. These findings suggest that the integrity of temporal structures in both hemispheres could be critical to spatial learning and memory and support the spatial component of the task. © 2011 Elsevier Inc.
Perales J.L.G.,University of the Sea |
Mendoza A.G.,Torrecardenas Hospital
Journal of Nuclear Medicine Technology | Year: 2010
In the daily practice of in-hospital or centralized radiopharmacies, there is a need to perform reliable numeric calculations. Furthermore, several nuclear medicine diagnostic tests also involve carrying out calculations. In both cases, these calculations are sometimes complex or tedious and prone to error. We report the development of a computer software program that performs a comprehensive range of calculations required in radiopharmacy and nuclear medicine diagnostic tests. Methods: This software was developed and compiled in the Visual Basic programming language using algorithms and methods reflected in the scientific literature. Results: We developed 2 versions of the software program, which we call Nucleolab. It automatically performs calculations relating to radiopharmacy practice as well as 9 diagnostic nuclear medicine tests. The 0.1 version performs all these calculations, and the 1.2 version also has a database that enables the user to save and recover diagnostic test results and issue custom reports. The software can be downloaded at www.radiofarmacia.org/nucleolab-english.Conclusion: To our knowledge, ours is the first attempt to develop a comprehensive software application that facilitates calculations in nuclear medicine and radiopharmacy, reducing errors and improving efficiency and accuracy. © 2010 by the Society of Nuclear Medicine, Inc.
Lopez-Ruzafa E.,Torrecardenas Hospital
Journal of Pediatric Hematology/Oncology | Year: 2016
Reticulocyte hemoglobin content (CHr) is considered an indicator of functional iron deficiency, but is understudied in children. The goals of this study are to determine the reference intervals for CHr in healthy children, and their relation with iron parameters, erythropoiesis, and individual conditions. A total of 902 children without iron deficiency, aged 1 to 11 years were analyzed in a cross-sectional study. Besides a physical examination of the subjects and a questionnaire completed by their parents, the complete blood count, serum transferrin receptor, ferritin, transferrin saturation, erythrocyte protoporphyrin, serum erythropoietin, C-reactive protein, and CHr levels were measured. Changes in CHr, iron status, and erythropoiesis at different age intervals were analyzed and linear multiple regression was used to identify the factors that determine CHr variability. Mean value obtained for CHr was 30.9±1.8 pg (P2.5-P97.5: 26.9 to 34.3 pg), but the influence of age on CHr (the values increased with age) and on the iron parameters justified the establishment of different reference ranges. In addition to age, nutritional status, hematologic measurements, reticulocytes, transferrin saturation, and erythrocyte protoporphyrin accounted for 39% of CHr variability. Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.
Ramos-Lizana J.,Torrecardenas Hospital |
Aguirre-Rodriguez J.,Torrecardenas Hospital |
Aguilera-Lopez P.,Torrecardenas Hospital |
Cassinello-Garcia E.,Torrecardenas Hospital
European Journal of Paediatric Neurology | Year: 2010
Aim: To study recurrence risk after withdrawal of antiepileptic drugs in children with epilepsy. Methods: All children younger than 14 with two or more unprovoked seizures 24 h apart who were seen at our Hospital between 1994 and 2004 were included consecutively and prospectively followed. Patients previously examined in other centres were excluded. All patients who entered a remission were proposed to stop medication and were followed. Results: Three hundred and fifty three children with two or more unprovoked seizures were attended. A total of 238 entered a remission period and were proposed to stop medication, 216 accept. Mean seizure-free time before medication withdrawal was 2.2 years. Kaplan-Meier estimate of recurrence risk was 23% at 2 years (95% CI: 17-29) and 28% at 5 years (95% CI: 22-34). A remote symptomatic etiology, various seizure types and a history of prior febrile seizures or prior neonatal seizures were associated with a significant increase in recurrence risk in univariable and multivariable analyses using Cox proportional hazards model. Recurrence risk at 2 years was 17% (95% CI: 11-23) for idiopathic/cryptogenic epilepsies and 41% (85% CI: 28-54) for remote symptomatic epilepsies. Recurrence risks at 2 years by epileptic syndrome were West syndrome (0%), benign rolandic epilepsy (10%), epilepsy without unequivocal partial or generalized seizures (11%), benign infantile seizures (13%), absence epilepsy (16%), cryptogenic partial epilepsies (20%), symptomatic partial epilepsies (45%), symptomatic generalized epilepsies (54%). Conclusions: Recurrence risk after withdrawal of antiepileptic treatment in children is low. Etiology and syndromic diagnosis are the main predictive factors. © 2009 European Paediatric Neurology Society.
Marquez M.F.,Torrecardenas Hospital |
Ayza M.F.,Torrecardenas Hospital |
Lozano R.B.,Torrecardenas Hospital |
Del Mar Rico Morales M.,Torrecardenas Hospital |
And 2 more authors.
Obesity Surgery | Year: 2010
Sleeve gastrectomy is a recently developed technique for treating morbid obesity. Since it is a simple procedure, the number of surgeons using it has grown in recent years. The patients who present fistulas after surgery often undergo a harrowing postoperative period as well as increased morbidity and mortality. Our aim was to assess the incidence, causes, diagnosis, management, and prevention of leaks after sleeve gastrectomy. © 2010 Springer Science + Business Media, LLC.
Ferrer-Marquez M.,Torrecardenas Hospital |
Belda-Lozano R.,Torrecardenas Hospital |
Ferrer-Ayza M.,Torrecardenas Hospital
Obesity Surgery | Year: 2012
Laparoscopic sleeve gastrectomy is a recently developed technique for treating morbid obesity. Since it is a simple procedure, many bariatric surgeons have adopted it in recent years with good results. However, there is still no standard procedure across different surgical teams. We will discuss the more controversial aspects of the surgical technique: the size of the bougie, the beginning of the distal section, the section shape at the gastroesophageal junction, the necessity and manner of reinforcing the staple line, and the routine use of intraoperative leak testing. © 2011 Springer Science + Business Media, LLC.
Moreno C.M.,Torrecardenas Hospital
Biogeochemistry | Year: 2012
UV-B radiation activates the synthesis of hydrogen peroxide from water and oxygen in many protein kinds, which having been discovered initially in antibodies, has been so far applied to explore new mechanisms in relation to immune defence. As shown here, the natural association of this common photocatalysis and catalase transforms UV-B photons into heat in a cyclic reaction that represents in biology a basic defence mechanism against UV-B radiation and cold, the activity of which drives the buoyancy and production of planktonic microorganisms in cold oceans. Moreover, given that UV-B radiation reaching the Earth's surface depends mainly on changes in the ozone layer, that defence mechanism over-activated by ozone depletion in microorganisms gathered at the top layer of the water column during seasonal production could result in accelerated sea ice melting, surface warming and ecosystem changes, such as is happening at high latitudes. Thus, one concludes that UV-B-driven photoproduction and decomposition of hydrogen peroxide in plankton can be a new, hidden biogeochemical process under control of the ozone layer with important effects on the ecosystem and climate. © 2011 The Author(s).