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Aurora, Canada

Ball M.,Astrazeneca | Boyd A.,Astrazeneca | Churchill G.,Astrazeneca | Cuthbert M.,Astrazeneca | And 15 more authors.
Organic Process Research and Development | Year: 2012

The intramolecular Diels-Alder reaction provides a useful synthetic methodology to build biologically active and synthetically useful isoindolone ring systems. An application of this methodology, providing an efficient manufacturing route to an mGluR2 positive allosteric modulator via a 1,5,7-substituted isoindolone, is reported herein. © 2012 American Chemical Society.

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