Topiwala National Medical College

Mumbai, India

Topiwala National Medical College

Mumbai, India

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PubMed | Research Division, JLN Medical College & Hospital, MS Ramaiah Medical College, Asthma Bhawan and 22 more.
Type: | Journal: American journal of respiratory and critical care medicine | Year: 2016

Interstitial lung disease (ILD) is a heterogeneous group of acute and chronic inflammatory and fibrotic lung diseases. Existing ILD registries have had variable findings. Little is known about the profile of ILDs in India.Create a prospective Registry with validation of diagnoses by multidisciplinary discussion (MDD) to characterize the clinical profile of new onset-ILD in India.Prospective recruitment of adult patients with new onset ILD (27 centers in 19 Indian cities, 3/2012-6/2015) with connective tissue disease (CTD) serologies and high-resolution computed tomography (HRCT) chest. Patients with malignancy and infection, including tuberculosis were excluded. ILD pattern was defined by HRCT images. Initial diagnosis was by site investigator. ILD experts at National Coordinating Center (NDCC), India with MDD, then evaluated data and final diagnoses were further validated by MDD among experienced ILD experts at the Center for ILD (CILD), Seattle, USA.1084 patients were recruited. Final diagnosis: Hypersensitivity pneumonitis (HP) in 47.3% (n=519; exposure: 48.1% aircoolers), CTD-ILD in 13.9% and Idiopathic Pulmonary Fibrosis (IPF) in 13.7%. Cohens kappa for reliability of interobserver agreement: 0.351 site investigators and CILD, 0.519 site investigator and NDCC, 0.618 NDCC and CILD.The majority of patients with ILD in India have HP followed by CTD-ILD and IPF; diagnoses varied between site investigators and CILD experts in the US, emphasizing the value of MDD in ILD diagnosis. Prompted case report forms including environmental exposures in prospective registries will likely provide further insight into the etiology, understanding and management of ILD worldwide.


Kostick K.M.,University of Connecticut | Schensul S.L.,University of Connecticut | Jadhav K.,Topiwala National Medical College | Singh R.,International Center for Research on Women | And 2 more authors.
Culture, Medicine and Psychiatry | Year: 2010

Vaginal discharge (safed pani in Hindi, meaning "white water") is one of the leading symptoms for which women in India seek care. Treatment-seeking for safed pani is disproportionately high among poor women, representing a physical, emotional and financial burden for low-income families. Safed pani is only rarely indicative of a reproductive tract or sexually transmitted infection. The discrepancy between symptom reports and observed pathology has led some researchers to characterize safed pani as a culturally based expression of more generalized negative life situation. Data are drawn from two prevention intervention studies (2002-2006 and 2007-2012) conducted in economically marginal communities in Mumbai. Results show that husbands as problem generators and spousal abusers and women's greater perceived empowerment and reported tension are significantly associated with safed pani. These results provide the basis for identifying women at greater risk for psychosocial distress and providing supports at the locations at which they seek treatment. © 2010 Springer Science+Business Media, LLC.


Sharma I.,Banaras Hindu University | Reddy K.R.,Manasa Hospital | Kamath R.M.,Topiwala National Medical College
Indian Journal of Psychiatry | Year: 2015

The Special Marriage Act (SMA), 1954 and the Hindu Marriage Act (HMA), 1955 have put restrictions on the marriage of persons with mental illness, which are proving to be detrimental to patients and their families. There is an urgent need to address this problem. The deficiencies in the existing legislation have been projected and constructive suggestions have been put forward.


The International Association of HealthCare Professionals is pleased to welcome Shyam Chandru Shivdasani, MD, Internist, to their prestigious organization with his upcoming publication in The Leading Physicians of the World. Dr. Shivdasani is a highly trained and qualified Internist with an extensive expertise in all facets of his work. Dr. Shyam Chandru Shivdasani has been in practice for more than 26 years and is currently serving patients as an Internist at his own private practice located in New Rochelle, New York. Furthermore, he is also affiliated with North Shore-LIJ Health System, Northwell Health, and Montefiore Medical Center. Dr. Shyam Chandru Shivdasani graduated with his Medical Degree in 1990 from the Topiwala National Medical College in Mumbai, India. Upon relocating to the United States, Dr. Shivdasani went on to complete his internship and then residency were at the Elmhurst Hospital Center in New York. Dr. Shivdasani is certified by the American Board of Internal Medicine, and is renowned as a specialist in internal medicine and interventional cardiology. He is a past member of the American Medical Association, and has had many articles published in the medical press. Dr. Shivdasani attributes his great success to his diligence, compassion, and good listening skills. When he is not attending to his patients, Dr. Shivdasani enjoys playing tennis, listening to music, and spinning. Learn more about Dr. Shivdasani by reading his upcoming publication in The Leading Physicians of the World. FindaTopDoc.com is a hub for all things medicine, featuring detailed descriptions of medical professionals across all areas of expertise, and information on thousands of healthcare topics.  Each month, millions of patients use FindaTopDoc to find a doctor nearby and instantly book an appointment online or create a review.  FindaTopDoc.com features each doctor’s full professional biography highlighting their achievements, experience, patient reviews and areas of expertise.  A leading provider of valuable health information that helps empower patient and doctor alike, FindaTopDoc enables readers to live a happier and healthier life.  For more information about FindaTopDoc, visit http://www.findatopdoc.com


Maksane S.,Jawaharlal Nehru Medical College | Ranka R.,Jawaharlal Nehru Medical College | Maksane N.,Topiwala National Medical College | Sharma A.,Jawaharlal Nehru Medical College
Asian Journal of Biochemistry | Year: 2011

The aim was to evaluate changes in serum magnesium and lipid profile in pre-eclamptics, their correlation with each other and roles of these changes in its Pathophysiology. Serum magnesium levels were determined by Calmagite method and total lipid profile by enzymatic calorimetric method in healthy non pregnant women (Group-1), primigravidas with normal pregnancy (Group-2) andprimigravidas with pre-eclampsia (Group-3). Results of Group-2 were compared with Group-1 and results of Group-3 were compared with Group-2. Compared with normal pregnancy, in pre-eclampsia the level of TG (Triglycerides) (p<0.0001) and VLDL-C (Very Low Density Lipoprotein Cholesterol) (p<0.0001), LDL-C (Low Density Lipoprotein Cholesterol) (p<0.012) were significantly increased and HDL-C (High Density Lipoprotein Cholesterol) (p<0.0001) and Mg++ (p<0.001) levels were decreased significantly. In normotensive pregnant women TG (p<0.0001) and VLDL-C (p<0.0001) and HDL-C (p<0.0001) levels were high and LDL-C (p<0.0001) level was low compared to healthy non pregnant women. No significant change could be observed in serum Mg in Group-2 as compared to Group-1 (p<0.2636). No significant change could be observed in total cholesterol level in any group. In addition serum TG correlated negatively(r = -0.47) with serum Magnesium in Pre-eclampsia. Theinverse correlation between serum Mg++ and serum triglycerides in pre-eclampsia may suggest the role of magnesium in the pathogenesis of pre-eclampsia along with dyslipidemia. During pregnancy, detection of hypomagnesaemia and dyslipidemia early will prevent its metabolic complication and in established pre-eclamptic women it will help in better management of the disease. © 2011 Academic Journals Inc.


Wakade D.V.,Topiwala National Medical College | Nayak C.S.,BYL Nair Charitable Hospital | Bhatt K.D.,UBM Institute
Acta medica (Hradec Králové) / Universitas Carolina, Facultas Medica Hradec Králové | Year: 2016

BACKGROUND: Radio frequency (RF) and chemical peels have been used for nonablative skin rejuvenation. Both of these cause collagen remodeling in the dermis and neo-collagen formation resulting in facial rejuvenation. There is limited literature on the evaluation of collagen remodeling by objective methods.OBJECTIVE: To compare the benefits of monopolar radiofrequency and glycolic acid peels in facial rejuvenation with regards to histopathology and Ultrabiomicroscopic sonography (UBM).METHODOLOGY: In this study, forty patients with mild to moderate photoaging received four treatments with 3 weeks interval of monopolar radiofrequency on one side of face and glycolic acid peels in increasing concentrations (NeostrataR) on the other side. Pre and post treatment, 2 mm biopsies were taken from both preauricular areas and Ultrasonography using a 35 MHz probe was done from outer canthus of eye and nasolabial folds from both sides of face. A blinded assessment was done to measure the increase in the grenz zone and dermal thickness.RESULTS: In 35/40 patients there was a significant increase in the grenz zone on histopathology and decrease in subepidermal low-echogenic band (SLEB) on UBM of the nasolabial folds on both sides of the face (p < 0.05).CONCLUSION: Radiofrequency and chemical peels showed equal efficacy in the treatment of facial rejuvenation.


PubMed | Topiwala National Medical College, UBM Institute and BYL Nair Charitable Hospital
Type: Comparative Study | Journal: Acta medica (Hradec Kralove) | Year: 2016

Radio frequency (RF) and chemical peels have been used for nonablative skin rejuvenation. Both of these cause collagen remodeling in the dermis and neo-collagen formation resulting in facial rejuvenation. There is limited literature on the evaluation of collagen remodeling by objective methods.To compare the benefits of monopolar radiofrequency and glycolic acid peels in facial rejuvenation with regards to histopathology and Ultrabiomicroscopic sonography (UBM).In this study, forty patients with mild to moderate photoaging received four treatments with 3 weeks interval of monopolar radiofrequency on one side of face and glycolic acid peels in increasing concentrations (NeostrataR) on the other side. Pre and post treatment, 2 mm biopsies were taken from both preauricular areas and Ultrasonography using a 35 MHz probe was done from outer canthus of eye and nasolabial folds from both sides of face. A blinded assessment was done to measure the increase in the grenz zone and dermal thickness.In 35/40 patients there was a significant increase in the grenz zone on histopathology and decrease in subepidermal low-echogenic band (SLEB) on UBM of the nasolabial folds on both sides of the face (p < 0.05).Radiofrequency and chemical peels showed equal efficacy in the treatment of facial rejuvenation.


Agrawal V.,Speciality ENT Hospital | Agarwal P.K.,Speciality ENT Hospital | Agrawal A.,Topiwala National Medical College
Indian Journal of Otolaryngology and Head and Neck Surgery | Year: 2016

This study aims to define the surgical boundaries of adenoidectomy by demonstrating that recurrence of adenoids and its symptoms can be avoided if a complete adenoidectomy is performed, by following these surgical limits. A prospective descriptive study was carried out at Speciality ENT Hospital, Mumbai, India. Endoscopic adenoidectomy was performed in 83 patients using coblation technology. In all patients, adenoids were removed superiorly till the periosteum over the body of sphenoid; posteriorly till the pharyngobasilar fascia; laterally till fossa of Rosenmuller in the posterior part and till the torus tubarius in the anterior part; and inferiorly till the Passavant’s ridge. The patients were followed up postoperatively and a nasal endoscopy was done at the end of 1 year to look for any recurrence or regrowth of adenoids, so as to determine the efficacy of the procedure. A total of 83 patients underwent adenoidectomy with a mean age of 12.80 years. 12 patients were lost to follow up. Of the remaining 71 patients, no patient showed any evidence of recurrence of adenoid on follow-up nasal endoscopy done at the end of 1 year. Recurrence of adenoid post adenoidectomy is not seen if there is complete removal of adenoids. So it is essential that all adenoid tissue be removed during adenoidectomy. The complete removal of adenoids can be ensured by following the surgical limits of adenoidectomy. © 2016, Association of Otolaryngologists of India.


Set R.,Topiwala National Medical College | Shastri J.,Topiwala National Medical College
Indian Journal of Medical Microbiology | Year: 2011

The pathogenic potential of the rapidly growing mycobacteria (RGM) has started being recognized. This is due to more sensitive and specific techniques in the laboratory. The RGM are generally defined as nontuberculous species of mycobacteria that show visible growth on agar media within 7 days. RGM are widely distributed in nature and have been isolated from natural water, tap water, and soil. Several biochemical tests, high performance liquid chromatography, and molecular techniques have been developed for rapid identification of these species. The American Thoracic Society and the Infectious Disease Society of America recommend that RGM should be identified to the species level using a recognized acceptable methodology such as polymerase chain reaction restriction enzyme analysis or biochemical testing and routine susceptibility testing of RGM should include amikacin, imipenem, doxycycline, the fluorinated quinolones, a sulphonamide or trimethoprim-sulphamethoxazole, cefoxitin, clarithromycin, linezolid, and tobramycin. The diseases caused by these organisms have varied manifestations. They have been responsible for a number of healthcare-associated outbreaks and pseudo-outbreaks. For recognition of outbreaks, it is important to be familiar with the causative organisms like RGM which are most frequently involved in healthcare-associated outbreaks and pseudo outbreaks. It is essential to intervene as soon as possible to interrupt this transmission. Large gaps still exist in our knowledge of RGM. Unquestionably more studies are required. Through this review, we wish to emphasize that reporting of RGM from clinical settings along with their sensitivity patterns is an absolute need of the hour.

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