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Wei Y.-M.,Peking University | Yang H.-X.,Peking University | Zhu W.-W.,Peking University | Liu X.-Y.,University of Florida | And 14 more authors.
Journal of Maternal-Fetal and Neonatal Medicine | Year: 2016

Objective: To estimate the risk of adverse maternal and perinatal outcomes in women with different pre-pregnancy body mass index (BMI).Methods: We conducted a cohort study with 14 451 singleton pregnancies in 15 medical centers in Beijing between 20 June 2013 and 30 November 2013 using cluster random sampling. We divided participants into four groups based on pre-pregnancy BMI: Group A (underweight): BMI < 18.5 kg/m2, Group B (normal): 18.5-23.9 kg/m2, Group C (overweight): 24-27.9 kg/m2, Group D (obesity): ≥28 kg/m2. We used multivariate analysis to evaluate the association of the risk of adverse pregnancy outcomes and pre-pregnancy BMI.Results: The prevalence of maternal overweight and obesity was 14.82% (2142/14 451) and 4.71% (680/14 451) in the study population, respectively. Higher pre-pregnancy BMI is associated with higher prevalence of gestational diabetes (GDM), macrosomia, Cesarean section (C-section), preeclampsia and postpartum hemorrhage. Pre-pregnancy overweight or obesity increases the risk of adverse pregnancy outcomes, regardless of GDM status.Conclusions: Pre-pregnancy overweight or obesity is associated with increased risk of adverse pregnancy outcomes. Nutrition counseling is recommended before pregnancy in women who have overweight or obesity. © 2015 Taylor & Francis. Source

Zhou Y.,Tongzhou Maternal and Child Health Hospital of Beijing | Yi R.,Beijing Army General Hospital | He J.,Beijing Army General Hospital | Yang Y.,Beijing Army General Hospital | And 3 more authors.
Neurological Sciences | Year: 2016

In this study, transcranial Doppler ultrasonography (TCD) and photoplethysmography (PPG) have been utilized, through the observation of peripheral and cerebrovascular hemodynamic changes of the disorder of consciousness (DOC) patients, measured on clinical behavior scale of Coma Recovery Score-Revised (CRS-R) to obesrve their diagnostic value in evaluation of DOC patients. TCD ultrasound was used to evaluate the flow velocity and waveform patterns of middle cerebral artery (MCA), while PPG infrared signals were utilized to assess the peripheral circulation as a mean of measuring cardiovascular activities. The research was carried out on a sample of 36 individuals, of which 16 met the DOC criteria and 20 were healthy individuals. Each person in the patients groups was assessed by the CRS-R. The velocity of middle cerebral artery in tested patients in a whole cardiac cycle, detected by TCD, decreased comparing with normal values. The values of pulsatility index (PI) of the MCA increased in patients groups comparing with normal. Through binary variables correlation analysis, we found that the PI of the left MCA of TCD of the patients significantly inversely correlated with their motor subscore, included in their CRS-R in the level of α = 0.05 (Pearson’s product-moment correlation coefficient = −0.556, p = 0.025). The values of photoplethysmographic augmentation index (PAI) that were detected by PPG increased comparing with normal. Finally, using binary variables correlation analysis we found the significant inverse correlation between the PAI of PPG and the mean velocity of the left MCA of the TCD in the level of α = 0.05 (Pearson’s product-moment correlation coefficient = −0.377, p = 0.022) in all the groups. The results of this study revealed a specific relationship between PI and PAI in the DOC patients. That relationship can potentially be exploited to enhance the capabilities in early assessment of the deconditioning of the DOC patients’ cardiovascular system and its influence on their cerebral vascular system. Ultimately, the dependency discovered can assist in predicting the tendency of the prognosis of the DOC patients in clinic. © 2016, The Author(s). Source

Gong C.-X.,Capital Medical University | Wei L.-Y.,Capital Medical University | Wu D.,Capital Medical University | Cao B.-Y.,Capital Medical University | And 2 more authors.
International Journal of Endocrinology | Year: 2014

Aims. To determine whether multiple daily injections (MDIs) or continuous subcutaneous insulin infusion (CSII) contributes to better glucose control in children with different type 1 diabetes duration. Methods. Subjects were grouped according to early (≤1 year after disease onset; 1A) or late (1-3 years after onset; 2A) MDIs/CSII treatment initiation. Corresponding control groups (1B, 2B) received insulin injections twice daily. Results. HbA1c levels were consistently lower in group 1A than in group 1B (6 months (T2): 7.37% versus 8.21%; 12 months (T3): 7.61% versus 8.41%; 24/36 months (T4/T5): 7.61% versus 8.72%; all P < 0.05), but were lower in group 2A than in group 2B only at T2 (8.36% versus 9.19%; P = 0.04). Levels were lower in group 1A than in group 2A when disease duration was matched (7.61% versus 8.49%; P < 0.05). Logistic regression revealed no correlation between HbA1c level and MDIs/CSII therapy. HbA1c levels were only negatively related to insulin dosage. Conclusions. Blood glucose control was better in patients receiving MDIs/CSII than in those receiving conventional treatment. Early MDIs/CSII initiation resulted in prolonged maintenance of low HbA1c levels compared with late initiation. MDIs/CSII therapy should be combined with comprehensive management. Copyright © 2014 Chun-xiu Gong et al. Source

Li S.-J.,Tongzhou Maternal and Child Health Hospital of Beijing
International Journal of Ophthalmology | Year: 2011

AIM: To observe the clinical effect of corneal stem cell transplantation in the treatment of pterygium, and discuss how to reduce the recurrence after operation. METHODS: Corneal stem cell transplantation was performed for 112 eyes of 112 cases. RESULTS: Patients were followed up for 6 months to 2 years, recurrence rate was 2.7%. CONCLUSION: Corneal stem cell transplantation, an ideal technique, can effectively reduce the recurrence rate of pterygium. Source

Zhu W.-W.,Peking University | Yang H.-X.,Peking University | Yang H.-X.,Xian Jiaotong University | Wei Y.-M.,Peking University | And 14 more authors.
Diabetes Care | Year: 2013

OBJECTIVEdTo evaluate the value of fasting plasma glucose (FPG) value in the first prenatal visit to diagnose gestational diabetes mellitus (GDM). RESEARCH DESIGN AND METHODSdMedical records of 17,186 pregnant women attending prenatal clinics in 13 hospitals in China, including the Peking University First Hospital (PUFH), were examined. Patients with pre-GDMwere excluded; data for FPG at the first prenatal visit and one-step GDM screening with 75-g oral glucose tolerance test (OGTT) performed between 24 and 28 weeks of gestation were collected and analyzed. RESULTSdThe median 6 SD FPG value was 4.58 6 0.437. FPG decreased with increasing gestational age. FPG level at the first prenatal visit was strongly correlatedwith GDMdiagnosed at 24-28 gestational weeks (x2 = 959.3, P < 0.001). The incidences of GDM were 37.0, 52.7, and 66.2%, respectively, for women with FPG at the first prenatal visit between 5.10 and 5.59, 5.60 and 6.09, and 6.10-6.99 mmol/L. The data of PUFH were not statistically different from other hospitals. CONCLUSIONSdPregnant women (6.10#FPG,7.00mmol/L) should be considered and treated as GDM to improve outcomes; for women with FPG between 5.10 and 6.09 mmol/L, nutrition and exercise advice should be provided. An OGTT should be performed at 24-28 weeks to confirm or rule out GDM. Based on our data, we cannot support an FPG value 5.10 mmol/L at the first prenatal visit as the criterion for diagnosis of GDM. Copyright © 2013 by the American Diabetes Association. Source

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