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Wu D.,Tongxiang Dermatology Hospital | Wu L.,Tongxiang First Peoples Hospital | Yang Z.,Zhejiang University
Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences | Year: 2014

OBJECTIVE: To investigate the association between androgenetic alopecia (AGA) and metabolic syndrome (MS).METHODS: Literature on association between AGA and MS up to December 26, 2013 was searched from PubMed, Web of Knowledge, Scopus, Cochrance library, SinoMed, CNKI, Wanfang and VIP databases, and the studies met the eligibility criteria were selected. Meta-analysis was performed by using StataSE 12.0 software to determine the association between AGA and MS.RESULTS: Four case-control studies and 2 cross-sectional studies met the eligibility criteria, including 950 AGA subjects and 3056 control subjects were entered the analysis. Meta-analysis showed that AGA was significantly correlated with MS (OR=2.70, 95%CI: 1.67-4.37, P<0.01). Stratification analysis showed that AGA was significantly correlated with MS in male (OR=2.30, 95%CI: 1.33-3.98, P<0.01) and female subjects (OR=4.61, 95%CI: 1.26-16.94, P<0.05); and AGA was significantly correlated with MS in European (OR=5.29, 95%CI: 2.86-9.80, P<0.01) and Asian subjects (OR=1.92, 95%CI: 1.18-3.10, P<0.01).CONCLUSION: Based on the available data, AGA may be a risk factor for MS, indicating that AGA patients would be a targeting population for screening of metabolic syndrome. Source


Shen Q.-P.,Tongxiang First Peoples Hospital | Fan M.-Z.,Tongxiang First Peoples Hospital | Meng L.-Q.,Tongxiang First Peoples Hospital
Journal of Practical Oncology | Year: 2015

Objective: To assess the feasibility of patient-controlled intravenous analgesia (PCIA) for advanced cancer patients with severe pain in primary hospitals. Methods: Morphine PCIA was applied to 27 advanced cancer patients with poor analgesic effect by three-step analgesic ladder therapy. Numeric rating scales (NRS) score, pain relief rate, first pain relief time, average dosage and adverse reactions were observed. Results: In 27 patients, the pain relief rate was 92.6%, the average first pain relief time was 34.1 min, NRS score decreased from 8.75±1.34 to 1.61±2.32 after treatment of PCIA (P<0.05), and adverse reactions were mild. Conclusion: Morphine PCIA can be used for advanced cancer patients with severe pain in primary hospitals as the replacement of three-step analgesic ladder therapy. ©, 2015, Journal of Practical Oncology, Editorial Board. All right reserved. Source


Shen Q.-P.,Tongxiang First Peoples Hospital | Fan M.-Z.,Tongxiang First Peoples Hospital | Lai L.,Tongxiang First Peoples Hospital
Journal of Practical Oncology | Year: 2011

Objective: To study the correlative factors of neurotoxicity associated with oxaliplatin (L-OHP). Methods: Sixty-four cases of gastric cancer and intestinal cancer after radical resection who used L-OHP and 5-FU/CF chemotherapy were collected in the study. At the end of the sixth cycle, the grade of neurotoxicity, gross of L-OHP, interval time of L-OHP, patient age, sex, stage and position of tumor and toxic reaction were recorded. Results: All the factors were analyzed with Logistic regression model (α =0.05), six factors were identified in the univariate analysis, including patient age, gross of L-OHP, interval time of L-OHP, arrest of bone marrow, gastrointestinal reaction and hepatic dysfunction. The results of Logistic multivariate analysis (α =0.05) indicated that patient age, gross of L-OHP, interval time of L-OHP and arrest of bone marrow were the correlative factors. Conclusion: The dosage of L-OHP should be regulated to alleviate oxaliplatin-related neurotoxicity based on the patient age and other factors. Source

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