Li W.,Heilongjiang University |
Jiang K.,Heilongjiang University |
Lin Z.,Tong University
Proceedings - 2012 International Conference on Computer Science and Information Processing, CSIP 2012 | Year: 2012
In this paper, a local discontinuous Galerkin (LDG) method is is designed for solving the BBM-Burgers equation with four-order spatial derivatives. Our schemes extend the previous work of Xu and Shu  solving the nonlinear Schrödinger equations on LDG method. The L 2 stability of the LDG methods is proved for general solutions. Numerical results are shown to illustrate the accuracy and capability of the LDG method. © 2012 IEEE.
Wu B.,Tong University |
Li T.,Yuxi Peoples Hospital |
Cai J.,Yangzhou University |
Xu Y.,University of South China |
Zhao G.,Shanghai JiaoTong University
BMC Cancer | Year: 2014
Background: To analyze and compare the economic outcomes of adjuvant chemotherapy with capecitabine plus oxaliplatin (referred to as the XELOX strategy) and of S-1 (the S-1 strategy) for gastric cancer patients after D2 gastrectomy. Methods: A Markov model was developed to simulate the lifetime disease course associated with stage II or III gastric cancer after D2 gastrectomy. The lifetime quality-adjusted life years (QALYs), associated costs, and incremental cost-effectiveness ratios (ICERs) were estimated. The clinical data were derived from the results of pilot studies. Direct costs were estimated from the perspective of the Chinese healthcare system, and the utility data were measured from end-point observations of Chinese patients. Sensitivity analyses were used to explore the impact of uncertainty on the model's outcomes. Results: The combined adjuvant chemotherapy strategy with XELOX yielded the greatest increase in QALYs over the course of the disease (8.1 QALYs compared with 7.8 QALYs for the S-1 strategy and 6.2 for surgery alone). The incremental cost per QALY gained using the XELOX strategy was significantly lower than that for the S-1 strategy ($3,502 vs. $6,837, respectively). The results were sensitive to the costs of oxaliplatin and the hazard ratio of relapse-free survival. Conclusion: The observations reported herein suggest that adjuvant therapy with capecitabine plus oxaliplatin is a highly cost-effective strategy and more favorable treatment option than the S-1 strategy in patients with stage II or III gastric cancer who have undergone D2 gastrectomy. © 2014 Wu et al.
Shen W.,Tong University |
Yin W.-Y.,Tong University |
Yin W.-Y.,Zhejiang University |
Sun X.-W.,CAS Shanghai Institute of Microsystem and Information Technology |
Mao J.-F.,Tong University
Asia-Pacific Microwave Conference Proceedings, APMC | Year: 2010
A novel fourth-order substrate integrated waveguide (SIW) transversal filter with triple-mode microstrip resonator is presented. The triple-mode resonator is etched on the top metal layer of SIW cavity, so compact size can be achieved. The coupling scheme of filter exhibits transversal characteristic, and the design principle of the filter is simple. The filter has compact size and wide stopband in comparison with conventional SIW filters. An open stub was added on the port to get better frequency selectivity. Two SIW filter samples are designed and fabricated, with good agreement achieved between the measured and the simulated S-parameters. © 2010 IEICE Institute of Electronics Informati.
Ke S.Z.,Xiamen University |
Ni X.Y.,Xiamen University |
Zhang Y.H.,Xiamen University |
Wang Y.N.,Xiamen University |
And 2 more authors.
International Journal of Oncology | Year: 2013
Multidrug resistance (MDR) formation is an important problem in lung cancer chemotherapy. Our study showed that both camptothecin and cisplatin could not only induce ATM and NF-κB activation but also upregulate expression of the MDR-related genes ABCG2, MRP2 in NCI-H446 cells. Moreover, camptothecin and cisplatin-induced ABCG2 and MRP2 upregulation could be impaired by ATM and NF-κB inhibitors, indicating a relationship between ATM, NF-κB activation and MDR formation in lung cancer chemotherapy. Our study indicates that ATM may serve as a potential molecular target for MDR formation in lung cancer chemotherapy.
Ding X.,Jiangnan University |
Sun H.,Tong University |
Gu X.,Jiangnan University
Chemical Vapor Deposition | Year: 2014
The experimental results of the direct deposition of graphene films on a gallium nitride (GaN)/sapphire substrate by catalyst-free atmospheric pressure (AP)CVD are presented. The quality and thickness of the synthesized samples can be controlled by the growth conditions. The prepared graphene/GaN samples show excellent optical transparency especially in the visible and infrared wavebands. The electrical transport properties are studied in the temperature range 4-300 K. The results indicate an advance step towards graphene-based applications in microelectronics and optoeletronics. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Fang J.,Tongji University |
Lian S.,Tong University |
Lei X.,Tong University |
Liu L.,Tong University
ICTIS 2015 - 3rd International Conference on Transportation Information and Safety, Proceedings | Year: 2015
Based on the irregularities measured data by track inspection car from Wen-Fu Passenger Dedicated Line of Nanchang railway bureau, the irregularity characteristics of middle and long wave irregularities with the wavelength range of 1∼50m was researched. By using of Welch methods the changing discipline of track irregularities power spectrum were analyzed. And the irregularities power spectrum fitting functions were studied by the least squares optimization algorithm. Track irregularities power spectrum of Wen-Fu Passenger Dedicated Line has been proposed. The analyzed results show: in analyzed wavelength range, the most track irregularities spectrum of passenger dedicated line are equal to or lower than Germany high-speed irregularities' spectrum. And only in small wavelength range, track irregularities spectrums of passenger dedicated line are higher than that of Germany high-speed irregularities. © 2015 IEEE.
Gao J.-B.,Tong University |
Zhang B.-W.,Tong University |
Chen X.-H.,China Information Security Certification Center
Engineering Applications of Artificial Intelligence | Year: 2015
Semantic similarity measuring between words can be applied to many applications, such as Artificial Intelligence, Information Processing, Medical Care and Linguistics. In this paper, we present a new approach for semantic similarity measuring which is based on edge-counting and information content theory. Specifically, the proposed measure nonlinearly transforms the weighted shortest path length between the compared concepts to achieve the semantic similarity results, and the relation between parameters and the correlation value is discussed in detail. Experimental results show that the proposed approach not only achieves high correlation value against human ratings but also has better distribution characteristics of the correlation coefficient compared with several related works in the literature. In addition, the proposed method is computationally efficient due to the simplified ways of weighting the shortest path length between the concept pairs. © 2014 Elsevier Ltd.
Yang J.,Tong University |
Zhao H.,Tong University |
Xin Y.,Tong University |
Fan L.,Tong University
Journal of Cellular Biochemistry | Year: 2014
Lung cancer is the most common cause of death from cancer worldwide and recent studies have revealed that microRNAs play critical roles to regulate lung carcinogenesis. Here we present evidence to show the role of miR-198 in lung cancer development. Our results showed that ectopic expression of miR-198 inhibits the viability and induces the apoptosis of human non-small cell lung cancer cells A549 and NCI-H460, while miR-198 inhibition resulted in opposite changes. In nude mice miR-198 inhibits A549 growth of tumor graft. We further demonstrated that miR-198 directly targets fibroblast growth factor receptor 1 (FGFR1) in lung cancer cells. Restoring FGFR1 expression blocked the inhibitory function of miR-198, while FGFR1 inhibition achieved the similar phenotypes of miR-198 overexpression. Hence, our data delineates the molecular pathway by which miR-198 inhibits lung cancer cellular proliferation and induces apoptosis, and may have important implication for the treatment of lung carcinogenesis. © 2013 Wiley Periodicals, Inc.
Wang R.,Tong University |
Chen J.,Tong University |
Dong G.M.,Tong University
Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science | Year: 2013
Fast Fourier transform-based near-field acoustic holography requires that the measurement aperture should completely enclose the source, which is impractical for large-scale sound sources. Helmholtz equation least-squares method can reconstruct the acoustic field with fewer measurements than fast Fourier transform-based near-field acoustic holography. However, it is not suitable for reconstructing acoustic radiation from multiple sources or a complicated source which consists of several separated parts. To circumvent this difficulty and enhance the reconstruction accuracy, a new data extrapolation method based on the modified Helmholtz equation least-squares method is proposed. The base of this data extrapolation method is a modified Helmholtz equation least-squares method which expresses the acoustic field of a complicated source as the superposition of the acoustic radiation from all of its separated parts. Using the acoustic pressures reconstructed with the modified Helmholtz equation least-squares method, the measurement surface is extended through an iterative procedure. Meanwhile, Tikhonov regularization method together with generalized cross-validation parameter choice method is utilized to treat the ill-posed problem in reconstructions. In the end, taking the extrapolated pressures as input data, the acoustic field can be reconstructed more precisely. Numerical simulation and experimental results demonstrate that this method can significantly enhance the reconstruction accuracy and efficiency. © IMechE 2012.
Fu L.,Tong University |
Chen Y.,Tong University |
Xu M.,Tong University |
Wu X.,Tong University |
Dong W.,Tong University
Proceedings of the ASME Turbo Expo | Year: 2016
In turbofan engine, ice accretion on spinning cone may lead to a decline in the engine aerodynamic performance and an increase of the vibration amplitude of the engine. An understanding of the mechanisms responsible for ice shedding process is necessary in order to optimize the spinning cone design and de-icing system to avoid hazardous ice shedding. In this paper, the Cohesive Zone Method (CZM) and the eXtended Finite Element Method (XFEM) are introduced to simulate the ice shedding process from a spinning cone. The CZM is applied to simulate the initiation and propagation of ice/spinning cone interface crack. The XFEM is introduced to model crack path inside the ice. This research method could provide a reference for ice shedding analysis of other parts of aero-engine. The research result could also be used to further study on optimization of the electro-Thermal and hot-Air de-icing system and ice shedding trajectory and impact simulations. © Copyright 2016 by ASME.