News Article | May 16, 2017
ARLINGTON, Va.--(BUSINESS WIRE)--The Consumer Technology Association (CTA) today announced Baidu’s Mr. Gu Weihao, GM of Baidu Intelligent Vehicle Division, will deliver a keynote address at CES Asia 2017 in Shanghai, China. The keynote is scheduled for 9:30 AM Thursday, June 8 at the Kerry Hotel, Level 3, Shanghai Ballroom 2-3. Mr. Gu is set to discuss Baidu’s ‘Apollo Plan’ that Baidu will provide an open, complete and reliable software platform for its partners in the automotive and autonomous driving industry to develop their own autonomous driving systems. In addition, Mr. Gu will discuss Baidu’s strategy and partnerships behind the Apollo Milestone which will lower the bar for developing advanced driver-assist systems as well as self-driving prototypes, and lead the industry towards the first complete, open-source, self-driving platform. “Built on simplicity and reliability, Baidu is the leading internet platform in China and services the largest internet user population in the world,” said Gary Shapiro, president and CEO, CTA. “Baidu continues to innovate and grow in the age of mobility and connectivity using cutting-edge technology to power and enhance its products and services. We are excited to welcome Mr. Gu to the CES Asia 2017 keynote stage.” Mr. Gu is the GM of Baidu Intelligent Vehicle Division (‘Baidu iV’), which is dedicated to providing professional autonomous driving solutions to car manufacturers, Tier 1 suppliers, chip partners and other service providers. He formerly oversaw the development of many of Baidu’s products including Baidu mp3, video, and voice search plus Baidu map. Prior to his current position, he was the Vice GM of Baidu Map Division and the GM of Baidu Telematics. Mr. Gu graduated from Beijing Jiao Tong University and joined Baidu in 2003. At CES Asia, Baidu will be showcasing the future of vehicle technology in two locations: SNIEC, hall N3, booth 3070 and an outdoor exhibit presented by Baidu’s Intelligent Driving Group featuring Baidu Autonomous Driving technology. More than 400 companies are already slated to exhibit including 3M, Audio-Technica, Baidu, BMW, BYD, Carl Zeiss, Changhong Electric, China Mobile, Continental, Digital China, DJI, Dynaudio, Fossil/Misfit, Garmin, Gibson Brands, Goertek, Haier, Harman, Hisense, Honda, Huawei, Hyundai, JD.com, Konka Group, Mercedes-Benz, Monster, NavInfo, NEVS, Onkyo, OnStar, OtterBox, Pioneer, PPTV, Samsung, Scosche, Segway, Suning, Tencent, United States Postal Service, UPS, Valeo, Volvo, Voxx, Wacom and Yuneec. Ultimately, CES Asia 2017 is expected to draw more than 30,000 attendees and more than 1,100 global media to cover the latest tech innovation across 19 product categories, including major growth areas such as drones, the Internet of Things (IoT) and virtual reality. Visit CESAsia.com for more information on attending or exhibiting at CES Asia 2017. CES Asia industry attendees, media and exhibitors may access the keynotes with a valid show badge. Note to Editors: Journalists traveling from outside of China will require a J-1 or J-2 visa. For questions about exhibiting at CES Asia, contact Brian Moon at bmoon@CTA.tech or +1 703-907-4351. Owned and produced by the Consumer Technology Association (CTA)TM and co-produced by Shanghai Intex Exhibition Co., Ltd (Shanghai Intex), CES Asia is the premier event for the consumer technology industry, showcasing the full breadth and depth of the innovation value-chain in the Asian marketplace. Key global businesses come to this new event to grow and reinforce their brand by showcasing the latest products and technologies to consumer tech industry executives, foreign buyers, international media and a limited number of consumers from China. Attendees have exclusive access to some of the largest brands from China and around the world, while celebrating the innovation that defines the consumer technology sector. Consumer Technology Association (CTA) is the trade association representing the $292 billion U.S. consumer technology industry, which supports more than 15 million U.S. jobs. More than 2,200 companies – 80 percent are small businesses and startups; others are among the world’s best known brands – enjoy the benefits of CTA membership including policy advocacy, market research, technical education, industry promotion, standards development and the fostering of business and strategic relationships. CTA also owns and produces CES® – the world’s gathering place for all who thrive on the business of consumer technologies. Profits from CES are reinvested into CTA’s industry services. Shanghai Intex Exhibition Co., Ltd was originally the exhibition organizing business of Shanghai Intex, a pioneering exhibition organizer established in 1995. Shanghai Intex is jointly overseen by the China Council for the Promotion of International Trade (CCPIT) Shanghai and PNO Exhibition Investment (Dubai) Limited. Starting in 1998, Shanghai Intex has organized over 100 trade shows and conferences with a sum total exhibition space in excess of 2 million sqm. Shanghai Intex is comprised of professional teams with a wealth of experience in organizing major international events, covering the creative industry, healthcare, lifestyle, advanced manufacturing and consumer electronics.
News Article | May 16, 2017
M. Gu dévoilera "l'Apollo Plan" de Baidu, qui proposera à ses partenaires de l'industrie automobile et de la conduite autonome une plateforme logicielle ouverte, complète et fiable, autour de laquelle ils pourront développer leurs propres systèmes de conduite autonome. En outre, M. Gu abordera la stratégie et les partenariats de l'évènement Apolo chez Baidu, qui faciliteront le développement des systèmes d'aide à la conduite avancés et des prototypes autopilotés, emmenant l'industrie vers la première plateforme complète, open-source et autopilotée. “Fondée sur la simplicité et la fiabilité, Baidu est la plateforme Internet leader en Chine et offre ses services à la plus grande population d'utilisateurs Internet au monde,” a déclaré Gary Shapiro, président et CEO, CTA. “Baidu continue à innover et croître à l'ère de la mobilité et de la connectivité, utilisant des technologies de pointe pour alimenter et améliorer ses produits et services. Nous sommes ravis d'accueillir M. Gu sur la scène du CES Asia 2017.” M. Gu est le GM de la division "Véhicules intelligents" de Baidu (‘Baidu iV’), qui se concentre sur le développement de solutions de conduite autonome professionnelles pour les constructeurs automobiles, les fournisseurs de premier plan, les partenaires en électronique et autres prestataires de services. Il fut également responsable du développement de nombreux produits de Baidu comme le mp3, la vidéo, la recherche vocale ainsi que les cartes Baidu. Avant d'occuper sa fonction actuelle, il fut Vice GM de la division Cartes de Baidu et GM des systèmes télématiques de la compagnie. M. Gu est diplômé de la Beijing Jiao Tong University et a rejoint Baidu en 2003. Plus de 400 compagnies exposantes sont déjà attendues dont 3M, Audio-Technica, Baidu, BMW, BYD, Carl Zeiss, Changhong Electric, China Mobile, Continental, Digital China, DJI, Dynaudio, Fossil/Misfit, Garmin, Gibson Brands, Goertek, Haier, Harman, Hisense, Honda, Huawei, Hyundai, JD.com, Konka Group, Mercedes-Benz, Monster, NavInfo, NEVS, Onkyo, OnStar, OtterBox, Pioneer, PPTV, Samsung, Scosche, Segway, Suning, Tencent, United States Postal Service, UPS, Valeo, Volvo, Voxx, Wacom et Yuneec. Enfin, CES Asia 2017 compte attirer plus de 30 000 visiteurs et plus de 1 100 journalistes du monde entier, pour couvrir l'exposition des dernières innovations technologiques réparties sur 19 catégories de produits, notamment les secteurs enregistrant la plus forte croissance comme les drones, l'Internet des Objets (IdO) et la réalité virtuelle. Rendez-vous sur CESAsia.com pour plus d'informations sur les modalités d’exposition et d'inscription au CES Asia 2017. Les participants de l'industrie, les médias et les exposants de CES Asia ont accès aux présentations avec un badge valable pour le salon. Propriété et production de la Consumer Technology Association (CTA)TM et organisé conjointement par Shanghai Intex Exhibition Co., Ltd (Shanghai Intex), le salon CES Asia est l'événement principal pour le secteur de la technologie grand public, présentant toute la diversité et l’étendue de la chaîne de valeur liée à l’innovation sur le marché asiatique. Des sociétés internationales clés participeront à ce nouvel événement pour développer et renforcer leur marque en présentant les derniers produits et technologies aux cadres du secteur de l’électronique grand public, aux acheteurs étrangers, aux médias internationaux et à un nombre limité de consommateurs de Chine. Les participants bénéficieront d’un accès exclusif à certaines des plus grandes marques de Chine et du monde entier, tout en célébrant l’innovation qui définit le secteur de la technologie grand public. La Consumer Technology Association (CTA) est l’association commerciale qui représente le secteur américain des technologies grand public. La CTA pèse 292 milliards USD et soutient plus de 15 millions d'emplois aux États-Unis. Plus de 2 200 sociétés (dont 80 pour cent sont des petites entreprises et des startups, et d’autres parmi les marques les plus renommées au monde) tirent profit de leur adhésion à la CTA, notamment des services de défense des politiques, d’études de marché, de formations techniques, de promotion du secteur, d’élaboration de normes et de promotion des relations commerciales et stratégiques. La CTA est également propriétaire et productrice du salon CES®, le lieu de rassemblement mondial pour tous ceux dont les activités sont fondées sur les activités liées aux technologies grand public. Les bénéfices du CES sont réinvestis dans les services prodigués par la CTA au secteur. Shanghai Intex Exhibition Co., Ltd était à l'origine la division chargée de l'organisation des expositions d'Intex Shanghai, une société pionnière de l'organisation d'expositions fondée en 1995. Shanghai Intex est supervisée conjointement par le Conseil chinois pour la promotion du commerce international (CCPIT) de Shanghai et par PNO Exhibition Investment (Dubai) Limited. Depuis ses débuts en 1998, Intex a organisé plus de 100 salons professionnels et conférences, sur une surface totale d'exposition dépassant les 2 millions de mètres carrés. Shanghai Intex réunit des équipes professionnelles ayant à leur acquis une riche expérience de l'organisation d'événements internationaux majeurs axés sur les secteurs de la création, de la santé, des styles de vie, sur l'industrie manufacturière de pointe et sur l'électronique grand public.
News Article | June 27, 2017
With More than 25 Years in the Semiconductor Industry, Andy Lai is a Leading Sales Executive in the Greater China & South Asia Pacific SAN JOSE, CALIFORNIA--(Marketwired - June 27, 2017) - Integrated Device Technology, Inc. (IDT) (NASDAQ:IDTI) today announced the appointment of Andy Lai as its new Vice President of Sales of Greater China and South Asia Pacific, and Country Manager for China. A sales veteran with more than 25 years in the semiconductor industry, Mr. Lai's experience covers a wide range of products and markets, including cloud & networking, automotive, mobile, consumer electronics, telecom infrastructure, and industrial. "Mr. Lai has established himself as one of the leading sales executives in the Greater China market, and he is a welcome addition to our sales leadership team," said Chris Allexandre, Senior Vice President, Global Sales & Marketing at IDT. "Mr. Lai will help extend our leadership position in telecom infrastructure, cloud, networking communication, and mobile wireless power in this region; and will also lead our expansion into the fast-growing automotive and industrial market segments." "IDT has built a strong brand reputation through its focus on innovation and customer satisfaction, and I look forward to working with my new team to expand it," said Mr. Lai. "IDT is well-positioned in key growth markets, and I'm confident the Greater China and South Asia Pacific market will be receptive to our advanced solutions and the design challenges they are able to help solve." Prior to joining IDT, Mr. Lai served in a variety of leadership roles across multiple companies, including Analog Devices, National Semiconductor, Texas Instruments, Fairchild Semiconductor, and others. Mr Lai has been managing the Greater China & South Asia Pacific regions in multiple companies for the last 7 years. Mr. Lai holds an EMBA from Shanghai Jiao Tong University, and a Bachelor of Science degree in Engineering from North China Electric Power University. Integrated Device Technology, Inc. develops system-level solutions that optimize its customers' applications. IDT's market-leading products in RF, high performance timing, memory interface, real-time interconnect, optical interconnect, wireless power, and SmartSensors are among the company's broad array of complete mixed-signal solutions for the communications, computing, consumer, automotive and industrial segments. Headquartered in San Jose, Calif., IDT has design, manufacturing, sales facilities and distribution partners throughout the world. IDT stock is traded on the NASDAQ Global Select Stock Market® under the symbol "IDTI." Additional information about IDT can be found at www.IDT.com. Follow IDT on Facebook, LinkedIn, Twitter, YouTube and Google+. © 2017, Integrated Device Technology, Inc. IDT and the IDT logo are trademarks or registered trademarks of Integrated Device Technology, Inc., and its worldwide subsidiaries. All other brands, product names and marks are or may be trademarks or registered trademarks used to identify products or services of their respective owners.
News Article | May 29, 2017
First Nations and Inuit babies were hospitalized much more often in the first year of life compared with non-Indigenous babies, many for preventable illnesses, found a new study of infant hospitalizations in Quebec, Canada, published in CMAJ (Canadian Medical Association Journal) http://www. . The study included 19 770 First Nations babies, 3930 Inuit and 225 380 non-Indigenous infants born between 1996 and 2010 in the province of Quebec. First Nations and Inuit mothers were much younger than non-Indigenous mothers, with 22% of First Nations and 27% of Inuit mothers under age 20 compared with non-Indigenous mothers (3.3%). Indigenous mothers were more likely to live alone and have lower education levels compared with non-Indigenous mothers. They also had higher rates of chronic diseases such as pre-existing diabetes, high blood pressure and kidney disease as well as pregnancy complications such as gestational diabetes, gestational hypertension and preeclampsia. Both First Nations and Inuit infants are about twice as likely to be hospitalized in the first year of life compared with non-Indigenous infants. Respiratory diseases and infections were the most common causes of hospitalization. "The excess risks of these diseases may be related to infant immunizations and the quality of the living environment, and thus may be largely preventable, suggesting the need to improve infant immunization programs, promote breastfeeding and no smoking in the child's living environment, and improve living conditions in Indigenous communities," writes Drs. Hua He and Zhong-Cheng Luo, Xinhua Hospital, Shanghai, China, and Sainte-Justine Hospital, University of Montreal, Montreal, Quebec, with coauthors. "The findings identify substantial unmet needs in Indigenous infant disease prevention and medical care. There is an urgent need for interventions to reduce Indigenous versus non-Indigenous infant health inequalities," the authors conclude. The study was conducted by researchers at Xinhua Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai, China; Sainte-Justine Hospital and University of Montreal Hospital Research Centre, University of Montreal, Montreal, Quebec; Public Health Department, Cree Board of Health and Social Services, James Bay, Mistissini, Quebec; First Nations of Quebec and Labrador Health and Social Services Commission, Wendake, Quebec; and Nunavik Regional Board of Health and Social Services, Kuujjuaq, Quebec.
News Article | June 28, 2017
PHILADELPHIA, June 28, 2017 /PRNewswire/ -- Clarivate Analytics, the global leader in providing trusted insights and analytics that accelerate the pace of innovation announced that it is the exclusive data provider to ShanghaiRanking Consultancy (formerly Shanghai Jiao Tong University)'s global ranking of world universities in academic subjects, released today. The additional bibliometric data for the ranking came from InCites, an integrated web-based platform powered by the Web of Science. It allows for a more granular and more comprehensive report than in the previous eight years. Considered one of the most unbiased and influential rankings in the world due to its academic rigor, the 2017 ShanghaiRanking's Global Ranking of Academic Subjects includes 52 subjects, an expanded and more detailed look at subject areas, compared to previous years. The subjects are organized across five broad categories including natural sciences, engineering, life sciences, medical sciences and social sciences. "By using the InCites metrics from Web of Science, alongside other criteria for academic excellence nominated by top scholars, we were able to rank more than 4,000 global universities by academic subject," said Dr. Cheng Ying, Managing Director of the ShanghaiRanking Consultancy. "These different indicators are logically related and may be considered converging partial indicators that when combined provide robust and reliable evidence of research influence and standing." Highlights from this year's report feature the United States capturing the number one spot in all six medical sciences subjects, as well as taking 32 of the top subject positions overall, with China following the US and capturing eight of the top subjects in the engineering category. And, according to David Pendlebury, senior citation analyst with Clarivate Analytics, "It is significant that different Chinese universities obtained top positions in engineering subfields, showing that research excellence and impact in this broad area is dispersed across the nation and not concentrated at a single premier institution." Pendlebury continued, saying that "Singapore's Nanyang Technological University continues to show impressive improvement in its research impact and has now plainly secured world-class status in a number of fields. In the recently released Reuters ranking of Asia universities according to innovation (utilizing publication and patent citation data compiled by Clarivate Analytics), NTU jumped 10 places in rank, from 35th worldwide to 25th, 2016 to 2017." "We are pleased to partner with ShanghaiRanking Consultancy on this ranking as we know that navigating volumes of data is an ongoing challenge for institutions, funders and governments," said Emmanuel Thiveaud, VP, head of research analytics at Clarivate Analytics. "Rankings that leverage our unbiased and precise analytics can help these organizations cut through the clutter to radically reduce the time it takes to find the answers they are seeking." Clarivate™ Analytics accelerates the pace of innovation by providing trusted insights and analytics to customers around the world, enabling them to discover, protect and commercialize new ideas faster. Formerly the Intellectual Property and Science business of Thomson Reuters, we own and operate a collection of leading subscription-based businesses focused on scientific and academic research, patent analytics and regulatory standards, pharmaceutical and biotech intelligence, trademark protection, domain brand protection and intellectual property management. Clarivate™ Analytics is now an independent company with over 4,000 employees, operating in more than 100 countries and owns well‐known brands that include Web of Science™, Cortellis™, Derwent™, CompuMark™, MarkMonitor® and Techstreet™, among others. For more information, please visit clarivate.com.
News Article | June 27, 2017
Physicists from the University of Nebraska-Lincoln are seeing an everyday phenomenon in a new light. By focusing laser light to a brightness one billion times greater than the surface of the sun — the brightest light ever produced on Earth — the physicists have observed changes in a vision-enabling interaction between light and matter. Those changes yielded unique X-ray pulses with the potential to generate extremely high-resolution imagery useful for medical, engineering, scientific and security purposes. The team’s findings, detailed June 26 in the journal Nature Photonics, should also help inform future experiments involving high-intensity lasers. Donald Umstadter and colleagues at the university’s Extreme Light Laboratory fired their Diocles Laser at helium-suspended electrons to measure how the laser’s photons — considered both particles and waves of light — scattered from a single electron after striking it. Under typical conditions, as when light from a bulb or the sun strikes a surface, that scattering phenomenon makes vision possible. But an electron — the negatively charged particle present in matter-forming atoms — normally scatters just one photon of light at a time. And the average electron rarely enjoys even that privilege, Umstadter said, getting struck only once every four months or so. Though previous laser-based experiments had scattered a few photons from the same electron, Umstadter’s team managed to scatter nearly 1,000 photons at a time. At the ultra-high intensities produced by the laser, both the photons and electron behaved much differently than usual. “When we have this unimaginably bright light, it turns out that the scattering — this fundamental thing that makes everything visible — fundamentally changes in nature,” said Umstadter, the Leland and Dorothy Olson Professor of Physics and Astronomy. A photon from standard light will typically scatter at the same angle and energy it featured before striking the electron, regardless of how bright its light might be. Yet Umstadter’s team found that, above a certain threshold, the laser’s brightness altered the angle, shape and wavelength of that scattered light. “So it’s as if things appear differently as you turn up the brightness of the light, which is not something you normally would experience,” Umstadter said. “(An object) normally becomes brighter, but otherwise, it looks just like it did with a lower light level. But here, the light is changing (the object’s) appearance. The light’s coming off at different angles, with different colors, depending on how bright it is.” That phenomenon stemmed partly from a change in the electron, which abandoned its usual up-and-down motion in favor of a figure-8 flight pattern. As it would under normal conditions, the electron also ejected its own photon, which was jarred loose by the energy of the incoming photons. But the researchers found that the ejected photon absorbed the collective energy of all the scattered photons, granting it the energy and wavelength of an X-ray. The unique properties of that X-ray might be applied in multiple ways, Umstadter said. Its extreme but narrow range of energy, combined with its extraordinarily short duration, could help generate three-dimensional images on the nanoscopic scale while reducing the dose necessary to produce them. Those qualities might qualify it to hunt for tumors or microfractures that elude conventional X-rays, map the molecular landscapes of nanoscopic materials now finding their way into semiconductor technology, or detect increasingly sophisticated threats at security checkpoints. Atomic and molecular physicists could also employ the X-ray as a form of ultrafast camera to capture snapshots of electron motion or chemical reactions. As physicists themselves, Umstadter and his colleagues also expressed excitement for the scientific implications of their experiment. By establishing a relationship between the laser’s brightness and the properties of its scattered light, the team confirmed a recently proposed method for measuring a laser’s peak intensity. The study also supported several longstanding hypotheses that technological limitations had kept physicists from directly testing. “There were many theories, for many years, that had never been tested in the lab, because we never had a bright-enough light source to actually do the experiment,” Umstadter said. “There were various predictions for what would happen, and we have confirmed some of those predictions. “It’s all part of what we call electrodynamics. There are textbooks on classical electrodynamics that all physicists learn. So this, in a sense, was really a textbook experiment.” Umstadter authored the study with Sudeep Banerjee and Shouyuan Chen, research associate professors of physics and astronomy; Grigory Golovin and Cheng Liu, senior research associates in physics and astronomy; Wenchao Yan, Ping Zhang, Baozhen Zhao and Jun Zhang, postdoctoral researchers in physics and astronomy; Colton Fruhling and Daniel Haden, doctoral students in physics and astronomy; along with Min Chen and Ji Luo of Shanghai Jiao Tong University. The team received support from the Air Force Office for Scientific Research, the National Science Foundation, the U.S. Department of Energy’s Office of Science, the Department of Homeland Security’s Domestic Nuclear Detection Office, and the National Science Foundation of China.
News Article | June 20, 2017
Australia's fastest camera has revealed the time it takes for molecules to break apart. The experimental research, conducted by Griffith University's Centre for Quantum Dynamics, aims to help in the design of new molecules for materials science or drug discovery. The Centre is the only place in the country to have the machine in its Australian Attosecond Science Facility. Research published in Nature Communications shows how scientists can measure, in real-time, the time that it takes and the separation distance of two atoms when the bond is broken in the simplest diatomic molecule. The result in an astonishing 15 millionth of a billionth of a second at a distance of half a billionth of a metre. The research was led by Associate Professor of Physics Igor Litvinyuk and conducted in collaboration with theorists from Shanghai Jiao Tong University. Associate Professor Litvinyuk said the molecule was made of two protons and one electron which they shared. "That electron sharing is responsible for the chemical bond which binds the protons together to form the molecule," he said. "We made that molecule dissociate and observed how soon the electron would 'decide' at which proton it will remain. That is called 'electron localisation' or loss of sharing and it signifies a breakage of a chemical bond." Co-author Professor Robert Sang, Dean (Research) Griffith Sciences, said there was a fundamental interest in how molecules behaved. "This allows us to start thinking about how we might engineer a new molecule and is a stepping stone towards looking at that type of reality, particularly in areas like drug discovery," he said. "It's pretty amazing you can do measurements on this sort of timescale. We can even observe processes which are faster than that."
News Article | June 16, 2017
1. Scientists from A*STAR's Singapore Immunology Network (SIgN) and KK Women's and Children's Hospital (KKH) in Singapore have discovered that a fetus's immune system is established as early as the second trimester of pregnancy, and may be able to initiate immune responses independently of the mother's immune system. 2. These findings debunk commonly-held assumptions about fetal immunity, including the idea that the fetus's immune system develops much later in the pregnancy cycle, and is unable to mount an independent immune response, being dependent on the mother's immune system to defend itself against external pathogens. 3. The scientists also found that an unborn baby's immune system contains a unique mechanism to prevent rejection of the mother's cells, even as it develops independently. This mechanism is mediated by dendritic cells expressing the protein Arginase-2. 4. These findings represent a landmark shift in our understanding of human immune development, and also provide insights into the immune mechanisms involved in some pregnancy-related illnesses and developmental diseases. 5. The findings of this study have been published in the scientific journal Nature on 14 June 2017. 6. Dendritic cells are immune cells that act as the sentinels of the body's immune system. They detect and assess the threats posed by foreign pathogens to the body and decide whether to initiate an immune response. 7. A major finding of the study is that as early as the second trimester of pregnancy, the human fetus has developed a network of dendritic cells that is similar to that of mature adults. These fetal dendritic cells are able to perform key functions associated with adult dendritic cells. 8. However, the scientists also uncovered a key difference between fetal and adult dendritic cells - the former expresses high levels of a protein called Arginase-2, which dampens the immune system response. This mechanism of immunosuppression promoted by fetal dendritic cells helps to ensure that the fetus does not reject the mother's cells even as it begins to develop its own immune defences. 9. Furthermore, Arginase-2 regulates the ability of immune cells to secrete a key inflammatory signaling protein called TNFα. This prevents the fetus's immune system from overreacting, and initiating unwanted inflammatory immune responses that could impact the baby's ongoing development in the womb. 10. The dysregulation of TNFα production in the fetal immune system has been implicated in various pregnancy-related conditions and developmental diseases, such as gestational diabetes mellitus, recurrent spontenous miscarriage, and necrotising enterocolitis. Hence, in expressing Arginase-2, fetal dendritic cells play a critical role in fetal immune tolerance, and ensuring the overall healthy development of the fetus in the mother's womb. About the Agency for Science, Technology and Research (A*STAR) The Agency for Science, Technology and Research (A*STAR) is Singapore's lead public sector agency that spearheads economic oriented research to advance scientific discovery and develop innovative technology. Through open innovation, we collaborate with our partners in both the public and private sectors to benefit society. As a Science and Technology Organisation, A*STAR bridges the gap between academia and industry. Our research creates economic growth and jobs for Singapore, and enhances lives by contributing to societal benefits such as improving outcomes in healthcare, urban living, and sustainability. We play a key role in nurturing and developing a diversity of talent and leaders in our Agency and Research Institutes, the wider research community and industry. A*STAR oversees 18 biomedical sciences and physical sciences and engineering research entities primarily located in Biopolis and Fusionopolis. For more information on A*STAR, please visit http://www. . The Singapore Immunology Network (SIgN), officially inaugurated on 10 February 2006, is a research consortium under the Agency for Science, Technology and Research (A*STAR)'s Biomedical Research Council. The mandate of SIgN is to advance human immunology research and participate in international efforts to combat major health problems. Since its launch, SIgN has grown rapidly and currently includes 200 scientists from 25 different countries around the world working under 18 renowned Principal Investigators. At SIgN, researchers investigate immunity during infection and various inflammatory conditions including cancer and are supported by cutting edge technological research platforms and core services. Through this, SIgN aims to build a strong platform in basic human immunology research for better translation of research findings into clinical applications. SIgN also sets out to establish productive links with local and international institutions, and encourage the exchange of ideas and expertise between academic, industrial and clinical partners and thus contribute to a vibrant research environment in Singapore. For more information about SIgN, please visit http://www. . KK Women's and Children's Hospital (KKH) is a recognised leader and Singapore's largest tertiary referral centre for Obstetrics, Gynaecology, Paediatrics and Neonatology. Founded in 1858, the 830-bed academic medical institution leads in patient-centred management of high risk conditions in women and children. More than 500 specialists adopt a compassionate, multi-disciplinary and holistic approach to treatment, and harness medical innovations and technology to deliver the best medical care possible. Accredited as an Academic Medical Centre, KKH is a major teaching hospital for all three medical schools in Singapore, Duke-NUS Medical School, Yong Loo Lin School of Medicine and Lee Kong Chian School of Medicine. The Hospital also runs the largest specialist training programme for Obstetrics and Gynaecology and Paediatrics in the country. Both programmes are accredited by the Accreditation Council for Graduate Medical Education International (ACGME-I), and are highly rated for the high quality of clinical teaching and the commitment to translational research. For more information, please visit http://www. . Quote from Dr Florent Ginhoux, Senior Principal Investigator at SIgN, A*STAR, and joint-senior author of the study: "We are excited by the prospects this discovery holds for the growing field of research into fetal immunity, and the insights it provides into the very beginnings of the human immune system. Moving forward, we plan to expand our characterisation of the human fetal immune system beyond dendritic cells, to incorporate other key immune cells like B-cells or T-cells. Our eventual goal is to build an atlas of the fetal immune system. Hopefully, this will allow us to discover additional mechanisms of fetal tolerance, and identify gene signatures so that we can better evaluate fetal fitness and immunity." Quote from Associate Professor Jerry Chan, Senior Consultant, Department of Reproductive Medicine, at KK Women's and Children's Hospital, Singapore, and joint-senior author of the study: "We have known for a long time that maternal cells cross into the baby's blood stream, but are not rejected by the fetal immune system. It had been long thought that the fetal immune system does not reject these semi-foreign cells due to its immaturity. The discovery of a fully functional dendritic cell network by the second trimester of pregnancy challenges this belief, and the high expression of Arginase-2 by fetal dendritic cells may contribute to the ability of the fetus to tolerate the mother's cells. This new insight lays the foundation for future immune-directed therapies, and contributes to our knowledge of the fetal origins of certain pregnancy-associated conditions, such as pre-eclampsia." The research findings described in this media fact sheet can be found in the 14th June 2017 online issue of the scientific journal Nature, under the title, "Human fetal dendritic cells promote pre-natal T cell immune-suppression through arginase-2" by Naomi McGovern1, Amanda Shin1,2, Gillian Low1, Donovan Low1, Kaibo Duan1, Leong Jing 1 Singapore Immunology Network (SIgN), A*STAR, 8A Biomedical Grove, Immunos Building, Level 3 and 4, Singapore 2 Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China 3 SingHealth Translational Immunology and Inflammation Centre (STIIC), 20 College Road, the Academia, Level 8 Discovery Tower, Singapore 4 Department of Reproductive Medicine, KK Women's and Children's Hospital, Singapore 5 KK Research Centre, KK Women's and Children's Hospital, 100 Bukit Timah Road, Singapore 6 OBGYN-Academic Clinical Program, Duke-NUS, Duke-NUS Medical School, 8 College Road, Singapore 7 epartment of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, NUHS Tower Block, 1E Kent Ridge Road, Singapore 8 Experimental Fetal Medicine Group, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 9 Department of Pathology, Singapore General Hospital, 20 College Road, Singapore 10 Division of Colorectal Surgery, University Surgical Cluster, National University Health System,Singapore 11 Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore,1E Kent Ridge Road, Singapore 12 Department of Dermatology, DIAID, Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria 13 Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom 14 Myeloid Cell Biology, Life and Medical Science Institute, University of Bonn, 53115 Bonn Germany 15 Single Cell Genomics and Epigenomics Unit at the German Center for Neurodegenerative Diseases and the University of Bonn, 53175 Bonn, Germany 16 Cancer and Stem Cell Biology Program, Duke-NUS Graduate Medical School, Singapore
News Article | June 20, 2017
Australia's fastest camera has revealed the time it takes for molecules to break apart. The experimental research, conducted by Griffith University's Centre for Quantum Dynamics, aims to help in the design of new molecules for materials science or drug discovery. The Centre is the only place in the country to have the machine in its Australian Attosecond Science Facility. Research published in Nature Communications shows how scientists can measure, in real-time, the time that it takes and the separation distance of two atoms when the bond is broken in the simplest diatomic molecule. The result in an astonishing 15 millionth of a billionth of a second at a distance of half a billionth of a metre. The research was led by Associate Professor of Physics Igor Litvinyuk and conducted in collaboration with theorists from Shanghai Jiao Tong University. Associate Professor Litvinyuk said the molecule was made of two protons and one electron which they shared. "That electron sharing is responsible for the chemical bond which binds the protons together to form the molecule," he said. "We made that molecule dissociate and observed how soon the electron would 'decide' at which proton it will remain. That is called 'electron localisation' or loss of sharing and it signifies a breakage of a chemical bond". Co-author Professor Robert Sang, Dean (Research) Griffith Sciences, said there was a fundamental interest in how molecules behaved. "This allows us to start thinking about how we might engineer a new molecule and is a stepping stone towards looking at that type of reality, particularly in areas like drug discovery," he said. "It's pretty amazing you can do measurements on this sort of timescale. We can even observe processes which are faster than that."
News Article | June 20, 2017
The experimental research, conducted by Griffith University's Centre for Quantum Dynamics, aims to help in the design of new molecules for materials science or drug discovery. The Centre is the only place in the country to have the machine in its Australian Attosecond Science Facility. Research published in Nature Communications shows how scientists can measure, in real-time, the time that it takes and the separation distance of two atoms when the bond is broken in the simplest diatomic molecule. The result in an astonishing 15 millionth of a billionth of a second at a distance of half a billionth of a metre. The research was led by Associate Professor of Physics Igor Litvinyuk and conducted in collaboration with theorists from Shanghai Jiao Tong University.Associate Professor Litvinyuk said the molecule was made of two protons and one electron which they shared. "That electron sharing is responsible for the chemical bond which binds the protons together to form the molecule," he said. "We made that molecule dissociate and observed how soon the electron would 'decide' at which proton it will remain. That is called 'electron localisation' or loss of sharing and it signifies a breakage of a chemical bond". Co-author Professor Robert Sang, Dean (Research) Griffith Sciences, said there was a fundamental interest in how molecules behaved. "This allows us to start thinking about how we might engineer a new molecule and is a stepping stone towards looking at that type of reality, particularly in areas like drug discovery," he said. "It's pretty amazing you can do measurements on this sort of timescale. We can even observe processes which are faster than that." Explore further: Weak atomic bond, theorized 14 years ago, observed for first time More information: H. Xu et al. Observing electron localization in a dissociating H2+ molecule in real time, Nature Communications (2017). DOI: 10.1038/ncomms15849