Tomsk Cancer Research Institute Tomsk

Tomsk, Russia

Tomsk Cancer Research Institute Tomsk

Tomsk, Russia
SEARCH FILTERS
Time filter
Source Type

Spirina L.V.,Siberian State Medical University | Usynin Y.A.,Tomsk Cancer Research Institute Tomsk | Yurmazov Z.A.,Tomsk Cancer Research Institute Tomsk | Slonimskaya E.M.,Siberian State Medical University | And 2 more authors.
Molekuliarnaia biologiia | Year: 2017

Here, we have investigated the participation of nuclear factors NF-kB, HIF-1 and HIF-2, VEGF, VEGFR2, and carboanhydrase IX in clear-cell renal cancer. We have determined the expression and protein level of transcription factors, VEGF, VEGFR2, and carboanhydrase IX in tumor and normal tissues of 30 patients with kidney cancer. The Real-Time PCR and ELISA were used in the study. The low levels of HIF-1 mRNA expression associated with high levels of HIF-1 protein were also associated with metastasis. The expression levels of VEGF, VEGFR2, and their protein levels are increased in primary tumors of patients with disseminated kidney cancer compared to nonmetastatic cancer. No correlation was revealed between the content of mRNA and encoded proteins in the kidney cancer tissues. The changes in the ratios of mRNA levels and the respective proteins (HIF-1α, HIF-2, NF-kB, VEGF, VEGFR2, and carboanhydrase IX) may contribute to kidney-cancer metastasis.

Loading Tomsk Cancer Research Institute Tomsk collaborators
Loading Tomsk Cancer Research Institute Tomsk collaborators