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Abington, PA, United States

Lazarevic J.,Toll Center for Reproductive science | Wikarczuk M.,Abington IVF and Genetics | Wikarczuk M.,Toll Center for Reproductive science | Somkuti S.G.,Abington IVF and Genetics | And 7 more authors.
Journal of Experimental and Clinical Assisted Reproduction | Year: 2010

Objective: To determine if a less expensive, easier, and faster to perform HBA test is clinically equal to the more complicated, technically challenging and expensive SPA test as a reliable indicator of sperm fertilizing capacity. Design: Prospective study. Setting: Andrology laboratory within In Vitro Fertilization Program. Patient(s): Semen samples from 26 infertility couples were analyzed. Both, normal and male factor patients were included. Intervention(s): Male partner screening with the HBA and the SPA tests. Main Outcome Measure(s): Relationship between HBA and SPA test results. Result(s): The data obtained in this study showed no statistically significant relationship between the HBA and SPA results. The mean HBA scores 76.3%, 61.3% and 76.8% were statistically not significantly different as compared to patients with negative (<5), grey zone (5-8) and for positive (>8) sperm capacitation index values. Conclusion(s): The HBA is not predictive of the results of the SPA. Therefore, HBA test does not reduce the need for and cannot replace the SPA test in male partner screening prior to infertility treatment. © 2010 Lazarevic, et al. Source


Gradistanac J.,Abington IVF and Genetics | Gradistanac J.,Toll Center for Reproductive science | Wikarczuk M.,Abington IVF and Genetics | Wikarczuk M.,Toll Center for Reproductive science | And 8 more authors.
Archives of Biological Sciences | Year: 2011

We analyzed 93 couples undergoing male screening with the Sperm Penetration Assay (SPA) before in vitro fertilization and intracytoplasmic sperm injection (ICSI), to determine the accuracy of SPA for subsequent embryonic development, incidence of pregnancy and miscarriage rates (SAB). ICSI patients with the lowest SPA scores had significantly higher incidences of SAB than did patients in the other SPA groups. Sperm quality is higher with better SPA scores. Poor sperm quality has increased incidence of chromosomal abnormalities and is associated with early fetal loss. Couples with negative SPA are candidates for preimplantation genetic diagnosis, to reduce the incidence of SAB. Source

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