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Inoue K.,Japan National Cardiovascular Center Research Institute | Murakawa Y.,Teikyo University | Nogami A.,Yokohama Rosai Hospital | Shoda M.,TokyoWomens Medical University | And 7 more authors.
Journal of Arrhythmia | Year: 2013

To assess the current status of atrial fibrillation (AF) ablation in Japan, the Japanese Heart Rhythm Society (JHRS) instituted a national registry, the Japanese Catheter Ablation Registry of AF (J-CARAF). Methods: Using an online questionnaire, the JHRS invited electrophysiology centers in Japan to voluntarily and retrospectively register data regarding the AF ablation procedures performed in September, 2011. Results: A total of 128 centers submitted data regarding AF ablation procedures in 932 patients (age 62.±10.4 years; male 76.8%; paroxysmal AF 65.7%, CHADS2 score 1.0±.0). The majority received oral anticoagulant therapy during and following the procedure (68.9% and 97.5%, respectively). Pulmonary vein isolation (PVI) was performed in 97.5% of the patients; ipsilateral encircling PVI was the preferred technique (79.7%). Three-dimensional (3D) mapping systems and irrigated-tip catheters were used in 94.8% and 87.7% of the procedures, respectively. Ablation methods other than PVI were performed in 78.8% of all the patients and 73.5% of the patients with paroxysmal AF. Acute complications were reported in 6.2% of the patients, but no early deaths were recorded. Conclusions: Ipsilateral encircling PVI, using 3D mapping and irrigated-tip catheters, is the standard AF ablation method in Japan. However, adjunctive ablations were performed frequently, even in patients with paroxysmal AF. © 2013 Japanese Heart Rhythm Society. Published by Elsevier B.V. All rights reserved.

Hasegawa M.,TokyoWomens Medical University | Sakai F.,Saitama University | Arimura K.,TokyoWomens Medical University | Katsura H.,TokyoWomens Medical University | And 3 more authors.
Japanese Journal of Clinical Oncology | Year: 2014

An 80-year-old man underwent right upper lobectomy for the resection of multiple cysts accompanied by a nodule. The pathological diagnosis was adenocarcinoma with surrounding atypical epithelial cell proliferation in a Type 1 congenital cystic adenomatoid malformation/congenital pulmonary airway malformation. There was epidermal growth factor receptor mutation in the adenocarcinoma and surrounding atypical epithelial cells that had proliferated. Malignant transformation of congenital cystic adenomatoid malformation/congenital pulmonary airway malformation may be related to the epidermal growth factor receptor pathway in this case, with atypical epithelial cell proliferation as a precursor. We emphasize the importance of complete resection of congenital cystic adenomatoid malformation/congenital pulmonary airway malformation and the possibility of treatment with epidermal growth factor receptor tyrosine kinase inhibitors in epidermal growth factor receptor-mutated cases. © The Author 2014.

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