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Nishi-Tokyo-shi, Japan

Hasegawa Y.,Tokyo Metropolitan Childrens Hospital
Clinical calcium | Year: 2013

Rickets is a condition of inadequate mineralization of osteoid and cartilage at the growing ends of bones in children. In this brief review, we first explained the regulation of serum Ca and P concentrations to understand Rickets. Second, four types of sub-division of Rickets are presented ; 1) Vitamin D dysfunction-related, 2) Phosphate deficiency-related, 3) both 1) and 2) -related, 4) others. Finally, as most common entities, diagnosis and treatment in vitamin D deficiency and inherited hypophosphatemic Rickets/Osteomalacia are described. Over production of Klotho and inactivating mutations of FAM20c are explained as recent etiologies of non-hypercaluciuric inherited hypophosphatemic Rickets/Osteomalacia. Source


Okabe Y.,University of Toyama | Itazawa T.,University of Toyama | Adachi Y.,University of Toyama | Yoshida K.,National Center for Children Health and Development | And 4 more authors.
Pediatrics International | Year: 2011

Background: Most studies regarding the association of obesity with asthma have been performed in the Western countries. This study is a nationwide survey conducted in Japan. Methods: A cross-sectional and questionnaire-based survey was performed among children aged 6-7, 13-14, and 16-17 years, using the ISAAC questionnaire. Overweight was defined as BMI ≥ 90th according to the reference values for Japanese children obtained during 1978-1981. Results: Of a total of 179 218 children, 149 464 replied to the questionnaire (response rate 83.4%). After omitting incomplete data, 139 117 were analyzed. In all the age groups, being overweight was associated with current asthma after adjustment for confounding factors (adjusted OR: 1.24 in children 6-7 years of age, 1.31 in those 13-14 years, and 1.32 in those 16-17 years). These tendencies were observed in both genders. Overweight was a risk factor for nocturnal cough, independent of current asthma in the older age groups (adjusted OR: 1.21 in children 13-14 years, and 1.17 in those 16-17 years). Conclusions: There is a clear association between obesity and current asthma in Japanese school-aged children. Mechanisms through which obesity related with nocturnal cough might be different from those of obesity-associated asthma. © 2011 The Authors. Source


Honda M.,Tokyo Metropolitan Childrens Hospital | Warady B.A.,Pediatric Nephrology
Pediatric Nephrology | Year: 2010

Encapsulating peritoneal sclerosis (EPS) is the most serious complication of long-term peritoneal dialysis (PD), with a mortality rate that exceeds 30%. There have been many reports of the incidence of EPS being strongly correlated to the duration of PD. Patients on PD for longer than 5 years, and especially those receiving this treatment for more than 8 years, should undergo careful and repeated surveillance for risk factors associated with the development of EPS. The development of ultrafiltration failure, a high dialysate/plasma creatinine ratio, as determined by the peritoneal equilibration test, peritoneal calcification, a persistently elevated C-reactive protein level, and severe peritonitis in patients on PD for longer than 8 years are signals that should prompt the clinician to consider terminating PD as a possible means of preventing the development of EPS. The impact of the newer, biocompatible PD solutions on the incidence of EPS has not yet been determined. © 2008 IPNA. Source


Higuchi O.,University of Toyama | Adachi Y.,University of Toyama | Itazawa T.,University of Toyama | Ito Y.,University of Toyama | And 5 more authors.
Pediatric Allergy and Immunology | Year: 2012

Background: There is a complex relationship between rhinitis, asthma, and nocturnal cough. Methods: To evaluate whether rhinitis is an important risk factor for nocturnal cough and whether this effect is independent of asthma, we analyzed data collected using the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire in a population-based nationwide survey. A child who had experienced a dry cough at night in the past 12months in the absence of a cold was defined as having nocturnal cough. Results: After excluding 11,475 records with incomplete data, data from 136,506 children were analyzed. Nocturnal cough was significantly more prevalent in children with current rhinitis compared with children without rhinitis. The association between rhinitis and nocturnal cough was significant in children who had current asthma (adjusted OR [95% CI]: 2.26 [2.00-2.56] in children aged 6-7yr, 1.90 [1.58-2.30] in those aged 13-14yr, and 1.86 [1.60-2.19] in those aged 16-17yr), and this association was even higher among children who had no asthma (adjusted OR [95% CI]: 3.65 [3.36-3.97] in children aged 6-7yr, 3.05 [2.79-3.32] in those aged 13-14yr, and 2.69 [2.51-2.88] in those aged 16-17yr). Conclusions: There was a close association between rhinitis and nocturnal cough in young children through adolescents, and this effect was independent of asthma. Upper airways should be examined in children with nocturnal cough. © 2012 John Wiley & Sons A/S. Source


Okabe Y.,University of Toyama | Adachi Y.,University of Toyama | Itazawa T.,University of Toyama | Yoshida K.,Tokyo Metropolitan Childrens Hospital | And 4 more authors.
Pediatric Allergy and Immunology | Year: 2012

Obesity may increase the risk of subsequent asthma. We have previously reported that there is a clear association between obesity and asthma in Japanese school-aged children. To evaluate whether a similar association exists in younger children, a nationwide cross-sectional questionnaire-based survey was performed focusing on children aged 4-5yr. A child who had experienced wheezing during the past 12months and had ever been diagnosed with asthma by a physician was defined as having current asthma. Overweight and underweight were defined as BMI ≥90th percentile and ≤10th percentile, respectively, according to the reference values for Japanese children from 1978 to 1981. After excluding 2547 children because of incomplete data, 34,699 children were analyzed. Current asthma was significantly more prevalent in overweight children compared with underweight and normal weight children (13.2% for overweight vs. 10.5% for underweight and 11.1% for normal weight; both p<0.001). Even after adjusting for other variables, such as gender, other coexisting allergic diseases, and parental history of asthma, there was an association between overweight and current asthma (adjusted odds ratio: 1.23, 95% CI: 1.10-1.38, p<0.001). Even in preschool children, obesity is already associated with asthma, and there was no gender effect on this association. Physicians should consider the impact of obesity when managing asthma in younger children. © 2011 John Wiley & Sons A/S. Source

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