Tokyo Medical and Dental University

www.tmd.ac.jp/
Tokyo, Japan

is part of Japan's national university system. Tokyo Medical and Dental University offers baccalaureate and graduate degrees in medicine, dentistry, and related fields. Wikipedia.


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Patent
Kyoto University, Tokyo Medical, Dental University and Kagoshima University | Date: 2014-12-18

Provided is a pain-related compound, a pain-related pharmaceutical composition, and use of the same. Provided in one or more embodiments is a compound represented by Formula (I), a prodrug of the same, or a pharmaceutically permissible salt of any of the same.


Patent
Kyoto University, Tokyo Medical and Dental University | Date: 2017-02-01

A pharmaceutical composition for neovascular diseases, a pharmaceutical composition for inhibiting an angiogenic growth factor, and use of these pharmaceutical compositions are provided. In one or more embodiments, a pharmaceutical composition contains as an active ingredient a low molecular weight compound that is able to suppress the expression of the VEGF gene in cells or to reduce the production of VEGF protein from cells. In one or more embodiments, a pharmaceutical composition contains as an active ingredient a compound expressed by the following formula (I) or a prodrug thereof or pharmaceutically acceptable salts thereof


Patent
Kyoto University, Tokyo Medical and Dental University | Date: 2015-03-26

A pharmaceutical composition for neovascular diseases, a pharmaceutical composition for inhibiting an angiogenic growth factor, and use of these pharmaceutical compositions are provided. In one or more embodiments, a pharmaceutical composition contains as an active ingredient a low molecular weight compound that is able to suppress the expression of VEGF gene in cells or to reduce the production of VEGF protein from cells. In one or more embodiments, a pharmaceutical composition contains as an active ingredient a compound expressed by the following formula (I) or a prodrug thereof or pharmaceutically acceptable salts thereof.


Patent
Tokyo Medical, Dental University and TDK Corp | Date: 2017-06-14

Provided is a biomagnetism measurement device which is capable of accurately diagnosing the site of a disorder and can be easily and readily used. According to one embodiment of the present invention, this biomagnetism measurement device 1 comprises: a tube 10; an expansion part 11 which is positioned at a necessary region of the tube 10 and can expand as a result of supply of a gas; a magnetism sensor part 13 which is fixed to the inner wall of the expansion part 11 and detects a magnetic field external to the tube 10. Preferably, the tube 10 and the expansion part 11 are formed from the same material, and the wall thickness of the expansion part 11 is less than the wall thickness of the tube 10.


Patent
Sysmex Corporation, Tokyo Medical and Dental University | Date: 2016-12-27

A method comprises obtaining a first cell image of a cell by a first observation method, obtaining a second cell image of the cell by a second observation method that is different from the first observation method, and determining the region of the cell based on the first cell image and the second cell image.


Patent
EA Pharma Co., Tokyo Medical and Dental University | Date: 2017-02-13

Administration of isoleucine, leucine and valine is effective for the prophylaxis and/or therapy of idiopathic inflammatory myopathy or idiopathic inflammatory myopathy associated with steroid-induced myopathy that develops during the course of treatment. This method is effective for the prophylaxis and/or therapy of idiopathic inflammatory myopathy or idiopathic inflammatory myopathy associated with steroid-induced myopathy that develops during the course of treatment.


Patent
Tokyo Medical, Dental University and Lymphotec Inc. | Date: 2017-07-19

An object of the present invention is to provide a detection method for Mycoplasma by which a greater number of Mycoplasma species can be more quickly and easily detected with high sensitivity and accuracy, a set of a forward primer, a reverse primer and a probe for the detection and a kit containing the set. Mycoplasma in a test sample is detected by a multiplex real time quantitative PCR using one or more forward primers, each of which is an oligonucleotide consisting of a nucleotide sequence, which is selected from the group consisting of nucleotide sequences each consisting of continuous 17 to 30 nucleotides in the nucleotide sequence represented by SEQ ID No: 1, and which contains a nucleotide sequence at nucleotide positions 14 to 24 in SEQ ID No: 1; reverse primers, each of which is an oligonucleotide consisting of a nucleotide sequence, which is selected from the group consisting of nucleotide sequences each consisting of continuous 17 to 26 nucleotides in the one or more nucleotide sequences represented by SEQ ID Nos: 14 and 17 to 20; and a probe(s), which is an oligonucleotide, which consists of a nucleotide sequence selected from the group consisting of nucleotide sequences each consisting of continuous 17 to 26 nucleotides in the nucleotide sequence represented by SEQ ID No: 33, or which consists of a complementary nucleotide sequence thereto.


Patent
Sysmex Corporation, Tokyo Medical and Dental University | Date: 2017-07-05

A method comprises obtaining a first cell image of a cell by a first observation method, obtaining a second cell image of the cell by a second observation method that is different from the first observation method, and determining the region of the cell based on the first cell image and the second cell image.


Mizushima N.,Tokyo Medical and Dental University | Komatsu M.,Tokyo Metropolitan Institute of Medical Science
Cell | Year: 2011

Autophagy is the major intracellular degradation system by which cytoplasmic materials are delivered to and degraded in the lysosome. However, the purpose of autophagy is not the simple elimination of materials, but instead, autophagy serves as a dynamic recycling system that produces new building blocks and energy for cellular renovation and homeostasis. Here we provide a multidisciplinary review of our current understanding of autophagy's role in metabolic adaptation, intracellular quality control, and renovation during development and differentiation. We also explore how recent mouse models in combination with advances in human genetics are providing key insights into how the impairment or activation of autophagy contributes to pathogenesis of diverse diseases, from neurodegenerative diseases such as Parkinson disease to inflammatory disorders such as Crohn disease. © 2011 Elsevier Inc.


Mizushima N.,Tokyo Medical and Dental University
Current Opinion in Cell Biology | Year: 2010

The Atg1/ULK complex plays an essential role in the initiation of autophagy: receiving signals of cellular nutrient status, recruiting downstream Atg proteins to the autophagosome formation site, and governing autophagosome formation. Recent studies of mammalian Atg1 homologs (ULK1 and ULK2) have identified several novel interacting proteins, FIP200, mAtg13, and Atg101. FIP200 and Atg101 are not conserved in Saccharomyces cerevisiae, despite the high conservation rates of other downstream Atg proteins between the yeast and mammals. Furthermore, through studies of the Atg1/ULK1 complex, the molecular mechanism by which (m)TORC1 regulates autophagy is now being clarified in detail. © 2009 Elsevier Ltd.

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