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Nishi-Tokyo-shi, Japan

Nishimura T.,Chiyoda Corporation | Furihata M.,Chiyoda Corporation | Kubo H.,Chiyoda Corporation | Tani M.,Chiyoda Corporation | And 3 more authors.
World Journal of Gastroenterology | Year: 2011

Treatment with bevacizumab, an antiangiogenic agent, in patients with metastatic or unresectable colorectal cancer was approved less than 4 years ago in Japan. Bevacizumab improves the survival of patients with metastatic colorectal cancer; however, it may lead to complications such as bleeding, which are sometimes fatal. Bevacizumab should be administered only after careful consideration because the potential risks of therapy outweigh its benefits. Therefore, pharmaceutical companies do not recommend bevacizumab therapy for patients with brain metastases. While some reports support the cautious use of bevacizumab, others report that it is not always necessary to prohibit its use in patients with metastases to the central nervous system (CNS), including the brain. Thus, bevacizumab therapy in colorectal cancer patients with brain metas-tases is controversial, and it is unclear whether brain metastases are a risk factor for intracranial hemorrhage during anti-vascular endothelial growth factor (VEGF) therapy. We report a 64-year-old man and a 65-year-old man with recurrent colorectal cancer without brain metastases; these patients developed multi-focal and solitary intracranial hemorrhage, respectively, after the administration of bevacizumab. Our fndings suggest that intracranial hemorrhage can occur even if the patient does not have brain metastases prior to bevacizumab treatment and also suggest that brain metastases are not a risk factor for intracranial hemorrhage with bevacizumab treatment. These fndings also question the necessity of excluding patients with brain metastases from clinical trials on anti-VEGF therapy. © 2011 Baishideng. All rights reserved. Source


Ueda T.,Chiba Cancer Center | Kobayashi M.,Chiba Cancer Center | Komaru A.,Chiba Cancer Center | Fukazawa K.,Chiba Cancer Center | Akakura K.,Tokyo Koseinenkin Hospital
Japanese Journal of Cancer and Chemotherapy | Year: 2013

The incidence of prostate cancer in the Japanese population has increased because of the increase in life expectancy, consumption of westernized diets, and improvements in prostate cancer screening by using the prostate-specific antigen (PSA) test. Further, in the past 10 years, there have been great advancements in the treatment options available for prostate cancer. Radical treatment methods, such as robot-assisted surgery, intensity-modulated radiation therapy, and particle beam radiation therapy, may have anticancer effects and may improve the quality of life by preserving micturition ability and sexual function. Radiotherapy and endocrine therapy have been shown to prevent postoperative recurrence. Endocrine therapy has been demonstrated to be effective in preventing recurrence after radiotherapy. Moreover, endocrine therapy can be administered to patients at all stages of prostate cancer and is often used as the initial treatment for advanced prostate cancer, particularly in patients with metastasis. However, recurrence (relapse) after endocrine therapy is associated with a poor prognosis. In this study, we describe all the available treatment options for prostate cancer and the treatable and untreatable forms of recurrent prostate cancer. Source


Terada Y.,ASC Dermatology Service | Nagata M.,ASC Dermatology Service | Murayama N.,ASC Dermatology Service | Nanko H.,Tokyo Koseinenkin Hospital | Furue M.,Kyushu University
Journal of Dermatology | Year: 2011

Atopic dermatitis (AD) is a common skin disease encountered in both humans and dogs. Canine AD can be used in the analysis of naturally occurring AD; however, details of clinical comparison have been lacking. The purpose of this study is to compare those clinical features using the human diagnostic criteria (Japanese Dermatological Association, 2009). Fifty-one dogs with canine AD were evaluated by the human criteria. Prior to this study, canine AD was basically diagnosed by the fulfillment of two authentic canine AD criteria and a positive reaction against Dermatophagoides farinae in serum immunoglobulin E levels and/or in intradermal tests. Among the human AD criteria items, behavior corresponding to pruritus was observed in all 51 dogs. Skin lesions corresponding to eczematous dermatitis were seen in 50 dogs, and symmetrical distribution of skin lesions was noted in all 51 dogs. A chronic or chronically relapsing course was observed in 50 dogs. Based on these results, the concordance rate for the criteria was 96% (49/51). Differential diagnoses of AD were also investigated in the same manner. The concordance rate for the criteria was 0% (0/69) in scabies, 2% (1/50) in pyoderma, 0% (0/50) in demodicosis, 0% (0/9) in cutaneous lymphoma, 0% (0/2) in ichthyosis, 25% (2/7) in flea allergy, 48% (24/50) in seborrheic dermatitis and 75% (3/4) in food allergy. Canine AD is thus indicated as a valuable counterpart to human AD in clinical aspects. In addition, the human AD criteria could be applicable, with some modification, as provisional diagnostic criteria for canine AD. © 2011 Japanese Dermatological Association. Source


Nomiya T.,Japan National Institute of Radiological Sciences | Tsuji H.,Japan National Institute of Radiological Sciences | Maruyama K.,Japan National Institute of Radiological Sciences | Toyama S.,Japan National Institute of Radiological Sciences | And 6 more authors.
British Journal of Cancer | Year: 2014

Background:The purpose of this study was to evaluate the feasibility of a new shortened 3-week treatment schedule of carbon ion radiotherapy (CIRT) for prostate cancer.Methods:Beginning in May 2010, patients with T1b-T3bN0M0, histologically proven prostate adenocarcinoma were enrolled in the phase II trial of CIRT. Patients received 51.6 GyE in 12 fractions over 3 weeks (protocol 1002). The primary end point was defined as the incidence of late adverse events that were evaluated based on the Common Terminology Criteria for Adverse Events version 4.0. Biochemical failure was determined using the Phoenix definition (nadir +2.0 ng ml -1).Results:Forty-six patients were enrolled, and all patients were included in the analysis. The number of low-, intermediate-, and high-risk patients was 12 (26%), 9 (20%), and 25 (54%), respectively. The median follow-up period of surviving patients was 32.3 months. Two patients had intercurrent death without recurrence, and the remaining 44 patients were alive at the time of this analysis. In the analysis of late toxicities, grade 1 (G1) rectal haemorrhage was observed in 3 (7%) patients. The incidence of G1 haematuria was observed in 6 (13%) patients, and G1 urinary frequency was observed in 17 (37%) patients. No ≥G2 late toxicities were observed. In the analysis of acute toxicities, 2 (4%) patients showed G2 urinary frequency, and no other G2 acute toxicities were observed.Conclusions:The new shortened CIRT schedule over 3 weeks was considered as feasible. The analysis of long-term outcome is warranted. © 2014 Cancer Research UK. Source


Nakahara M.,Jikei University School of Medicine | Ninomiya K.,Jikei University School of Medicine | Masuzawa G.,Tokyo Koseinenkin Hospital
Tokyo Jikeikai Medical Journal | Year: 2010

A foreign body in the hand is a common outpatient injury. Sometimes, however, detecting a foreign body and determining its location can be difficult. We report a case in which an interview and medical examination of the patient were impossible and a foreign body was not visible on X-ray films. The foreign body remained in the patient's palm and was not removed until 1 month later. At initial examination, the patient had a contused 15-mm-long wound of the right palm but was too drunk to answer our questions. When the wound became infected 1 month later, we performed surgery and removed a 5 x 60-mm branch of wood from deep inside the palm. We believe that ultrasonography, which is able to detect objects of wood, glass, or metal, should have been performed at the initial examination. This case suggests that ultrasonography is useful and necessary for investigation of foreign bodies in selected cases. Source

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