Shimizu H.,Hiroshima University |
Daibo I.,Tokyo Future University
Shinrigaku Kenkyu | Year: 2014
The latent rank structure of the General Health Questionnaire (GHQ) was examined and a methodology for "ranking assessment" for use in clinical screening was suggested. Clinical screening is conducted by using dichotomous methods, which is problematic. Recent research has introduced the concept of ranking assessment, which is conducted by dividing clients into ordinal groups according to the Latent Rank Theory (LRT). Participants (N = 949, including 80 neurotic patients) completed the GHQ. They were then divided into four ordinal groups according to LRT. The usual cut-off point of the GHQ (16/17 points) distinguished the third and fourth rank group as the clinical group and the first-rank group as the healthy group. However, the second rank group was classified as neither a healthy or clinical group. These results indicate that the LRT has the potential to facilitate practical and flexible clinical screening.
PubMed | Institute of Microbial Chemistry BIKAKEN, Juntendo University, University of Tokyo, Tokyo Future University and 2 more.
Type: | Journal: International immunopharmacology | Year: 2016
Local infiltration of inflammatory cells is regulated by a number of biological steps during which the cells likely penetrate through subendothelial basement membranes that contain heparan sulfate proteoglycans. In the present study, we examined whether administration of heparastatin (SF4), an iminosugar-based inhibitor of heparanase, could suppress local inflammation and degradation of heparan sulfate proteoglycans in basement membranes. In a carrageenan- or formyl peptide-induced dorsal air pouch inflammation model, the number of infiltrated neutrophils and monocytes was significantly lower in mice after topical administration of heparastatin (SF4). The concentration of chemokines MIP-2 and KC in pouch exudates of drug-treated mice was similar to control. In a zymosan-induced peritonitis model, the number of infiltrated cells was not altered in drug-treated mice. To further test how heparastatin (SF4) influences transmigration of inflammatory neutrophils, its suppressive effect on migration and matrix degradation was examined in vitro. In the presence of heparastatin (SF4), the number of neutrophils that infiltrated across a Matrigel-coated polycarbonate membrane was significantly lower, while the number of neutrophils passing through an uncoated membrane was not altered. Lysate of bone marrow-derived neutrophils released sulfate-radiolabeled macromolecules from basement membrane-like extracellular matrix, which was suppressed by heparastatin (SF4). Heparan sulfate degradation activity was almost completely abolished after incubation of lysate with protein G-conjugated anti-heparanase monoclonal antibody, strongly suggesting that the activity was due to heparanase-mediated degradation. Taken together, in a dorsal air pouch inflammation model heparastatin (SF4) potentially suppresses extravasation of inflammatory cells by impairing the degradation of basement membrane heparan sulfate.
PubMed | SBI Pharmaceuticals Co., Tokyo Future University, Juntendo University, Institute of Microbial Chemistry and University of Tokyo
Type: Journal Article | Journal: Biochemical and biophysical research communications | Year: 2016
To explore possible roles of heparanase in cancer-host crosstalk, we examined whether heparanase influences expression of inflammatory chemokines in colorectal cancer cells. Murine colorectal carcinoma cells incubated with heparanase upregulated MCP-1, KC, and RANTES genes and released MCP-1 and KC proteins. Heparanase-dependent production of IL-8 was detected in two human colorectal carcinoma cell lines. Addition of a heparanase inhibitor Heparastatin (SF4) did not influence MCP-1 production, while both latent and mature forms of heparanase augmented MCP-1 release, suggesting that heparanase catalytic activity was dispensable for MCP-1 production. In contrast, addition of heparin to the medium suppressed MCP-1 release in a dose-dependent manner. Similarly, targeted suppression of Ext1 by RNAi significantly suppressed cell surface expression of heparan sulfate and MCP-1 production in colon 26 cells. Taken together, it is concluded that colon 26 cells transduce the heparanase-mediated signal through heparan sulfate binding. We propose a novel function for heparanase independent of its endoglycosidase activity, namely as a stimulant for chemokine production.
PubMed | Tokyo Future University and Osaka University of Economics
Type: | Journal: Frontiers in psychology | Year: 2016
This study examined whether interpersonal synchrony could be extracted using spectrum analysis (i.e., wavelet transform) in an unstructured conversation. Sixty-two female undergraduates were randomly paired and they engaged in a 6-min unstructured conversation. Interpersonal synchrony was evaluated by calculating the cross-wavelet coherence of the time-series movement data, extracted using a video-image analysis software. The existence of synchrony was tested using a pseudo-synchrony paradigm. In addition, the frequency at which the synchrony occurred and the distribution of the relative phase was explored. The results showed that the value of cross-wavelet coherence was higher in the experimental participant pairs than in the pseudo pairs. Further, the coherence value was higher in the frequency band under 0.5 Hz. These results support the validity of evaluating interpersonal synchron Behavioral mimicry and interpersonal syyby using wavelet transform even in an unstructured conversation. However, the role of relative phase was not clear; there was no significant difference between each relative-phase region. The theoretical contribution of these findings to the area of interpersonal coordination is discussed.
Kotani H.,Tokyo Future University |
Matsuno M.,Tokyo Future University |
Nakagawa H.,Tokyo Denki University
Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS | Year: 2015
In this study, we investigated variations in a women's cognitive function during a time of pregnancy and childbearing. Volunteers were composed of 114 healthy women ranging in age from 23-43 years with an average age of 31.8 years (SD=4.3). Further, 79 were pregnant and 35 were not pregnant. All the pregnant women were expecting their first child and continued with the cognitive function analysis after their childbearing was concluded. We instructed the pregnant women to carry out five kinds of tests: simple reaction, SR; choice reaction, CR; working memory, WM; one card learning, OC; and divided attention, DA using card games through a cognitive function test called 'CogHealth', and compared them to a nonpregnant group. In the results of the four measurement tasks (SR, CR, WM, and DA), there were no significant differences across the three groups in the responses with the tasks. However, the response times relating to the OC learning in the postnatal women were significantly smaller, as contrasted with the times for the pregnant and the nonpregnant women (F(2,144)=4.248, P < 0.05). Furthermore, we compared their cognitive functions between pregnant and postnatal states in corresponding volunteers in the responses with the same tasks. We also demonstrated the fact that postnatal women responded more quickly to tasks in the OC (t(32)=2.95, P < 0.01) and the WM (t(32)=3.03, P < 0.01) categories than responses to performing the tasks during their pregnancy. Our findings support the idea that the functions of pregnant/postnatal women are not failing, or rather postnatal women are more responsive in their reaction times with their memories by 2.7-6.2%, than the responses in both pregnant and nonpregnant women. © 2015 IEEE.
Fukui R.,University of Tokyo |
Morishita H.,HMI Corporation |
Sato T.,Tokyo Future University
Journal of Robotics and Mechatronics | Year: 2014
The purpose of this paper is to develop a ceiling hanging mobile robot for factories, offices and living spaces where human and robots can share spaces cooperatively. Based on an analysis of related work, we select two promising candidates of ceiling attachment method; a permanent magnet method and a mechanical constraint method. We combine these two ceiling attachment methods with practical locomotion methods, and realize two ceiling hanging mobile robots. Two different robots are designed and implemented based on our selected approaches. We evaluated the basic performances of those two robots in experiments. Difficulties in their design and implementation processes of the two robots are described, and technical insights are summarized based on the comparison of difficulties, safety, performance and cost. Discussions reveal that the two robots have quite different characteristics. In conclusion, two different application areas are proposed for the two robots with different ceiling attachment methods. Although there are large numbers of reports on wall climbing or ceiling hanging mobile robots, this paper is the first work, to our knowledge, to compare qualitatively and quantitatively the performances of multiple robots through development of real prototypes.
Lee J.,Nagoya University |
Takehashi H.,Tokyo Future University |
Nagai C.,Nagoya University |
Obinata G.,EcoTopia Science Institute
Proceedings - IEEE International Workshop on Robot and Human Interactive Communication | Year: 2012
Previous researches, in the field of robot assisted therapy, suggested that communications with robots encourage autistic children to have more positive reaction to the robots' behavior, and this seems to be a reliable approach to improve the social interaction and communication skills of autistic children. However, most of the researches focused on improving only some limited aspects of the autistic children's social communication problems and it is difficult to evaluate the training with current technology. Thus, in the present study, we suggest a training robot to improve the adjustability of autistic children's way of communications through touching. First, we explore three different ways of touching and compare different force levels of touching for autistic children to those for non-autistic children. As a result, non-autistic children have shown a definite pattern on the way of touching, while there is no pattern in autistic children's one. Second, we investigate the efficiency of therapy with the robot, when the robot shows its expression to a person with autism. As a result, the participant has indicated that better success rate with the presence of expression from robot. © 2012 IEEE.
Fukui R.,University of Tokyo |
Watanabe M.,Panasonic |
Shimosaka M.,University of Tokyo |
Sato T.,Tokyo Future University
International Journal of Robotics Research | Year: 2014
Hand gestures can potentially express rich information for communication between humans or between a human and a machine. However, existing hand-shape recognition methods have several problems in utilizing hand gestures in home automation. We have focused on 'wrist contour', and have developed a wrist-watch-type device that measures wrist contour using photo reflector arrays. In this paper, we address three challenges: improvement of hand-shape recognition performance, making clear the effect of personal difference, and identifying problems caused by pronation angle changes. To address the former two challenges, we have collected wrist contour data from 28 subjects and conducted two experiments. For the first challenge, three different feature types are compared. The results extract several important contour statistics and the classification rate is also improved by introducing multiple subjects' data for training. For the second challenge, we compose a resemblance matrix to evaluate resemblance among subjects. The results indicate that training data selection is important to improve classification performance. To address the third challenge, two inertial measurement units are installed in the device. We have collected wrist contour data in various pronation angles, and specific relationships are found between wrist contour data and pronation angles. © The Author(s) 2014.
Kitazawa T.,Tokyo Future University |
Mochizuki T.,Senshu University
Proceedings of the 21st International Conference on Computers in Education, ICCE 2013 | Year: 2013
New teachers who are shocked by real-world classroom situations - such as rules of the local school, human relationships in a shielded environment, and the reality of teaching children - Tend to leave the workforce within a few years, and it has become necessary to educate student teachers in the universities with a focus on adaptive professional socialization of teachers (Zeichner & Gore 1990) to overcome this problem. We have provided a weblog community where pre-service teachers can have a dialogue based on their report of experiences during their practice teaching. However, in order to promote the professional socialization of teachers, we have designed a new weblog community where experienced teachers can participate. Through comparative analysis, we have pursued the effectiveness of this change in design. In this study, we referred to Hong (2010) and categorized their diaries and comments within the weblog community into nine factors, and analyzed the features of their communication. We revised the design of the pre-teaching from the year 2010, and altered the lesson design of the pre-teaching for the year 2012 so that pre-service teachers could exchange their opinions focusing more on the ways of schools and teachers. The class design was changed so that experienced teachers provided hints during pre-teaching to motivate pre-service teachers to think about the issues, and the pre-service teachers were made to take the initiative in using the weblog. From the results, we found that the number of entries of diaries and comments into the weblog community differed between the years 2010 and 2012. Moreover, it became relevant that the ratio of the diary entries about "commitment towards work," "value and standpoint as teachers" and the like increased.
Kitazawa T.,Tokyo Future University
Proceedings of the International Conference e-Learning 2013 | Year: 2013
This study analyzed effective test formats that utilized tablets for tests in university information basic subjects in blended learning environments. Specifically, three types of test were created: (1) multiple-choice, (2) fill-in-the-blank, and (3) a mixture of multiple-choice and fill-in-the-blank. An analysis focusing on university students' approach-avoidance tendency was conducted to see how the question formats affected the students' motivations toward the tests. The results showed that regardless of the test approach-avoidance tendency, the students had a low perception of their understanding of the content of multiple-choice tests, even though they reported that they did not feel burdened in answering the questions. Additionally, although the students had a high perception of knowledge retention with fill-in-the-blank questions, their willingness to answer the questions and the percentage of questions they answered correctly were low. On the other hand, students had a high perception of continuity and a high percentage of correct answers on the test with a mixture of multiple-choice and fill-in-the-blank questions. Additionally, they had a high perception of knowledge retention in the mixed test, suggesting that this format had the strongest effect among the three test formats.