Tokushima, Japan
Tokushima, Japan

The University of Tokushima is a national university in the city of Tokushima, Japan, with seven graduate schools and five undergraduate faculties. The university was founded in 1949, by merging six national education facilities into one. The 2014 Nobel Prize Laureate in Physics, Shuji Nakamura graduated from Tokushima. Wikipedia.


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Anderson G.,University of Birmingham | Takahama Y.,Tokushima University
Trends in Immunology | Year: 2012

The thymus represents an epithelial-mesenchymal tissue, anatomically structured into discrete cortical and medullary regions that contain phenotypically and functionally distinct stromal cells, as well as thymocytes at defined stages of maturation. The stepwise progression of thymocyte development seems to require serial migration through these distinct thymic regions, where interactions with cortical thymic epithelial cell (cTEC) and medullary thymic epithelial cell (mTEC) subsets take place. Recent work on TEC subsets provides insight into T cell development and selection, such as the importance of tumour necrosis factor (TNF) receptor superfamily members in thymus medulla development, and the specialised antigen processing/presentation capacity of the thymic cortex for positive selection. Here, we summarise current knowledge on the development and function of the thymic microenvironment, paying particular attention to the cortical and medullary epithelial compartments. © 2012 Elsevier Ltd.


Patent
SBI Pharmaceuticals Co. and Tokushima University | Date: 2015-05-27

Provided is a prophylactic/therapeutic agent for influenza viral infection that is effective not only before and at an early stage of infection with influenza virus but also at an intermediate or late stage of the infection and is highly safe for human bodies. A prophylactic/therapeutic drug for influenza viral infection comprising, as active ingredients, 5-aminolevulinic acid (5-ALA), a derivative thereof or a salt of the 5-ALA or the derivative, and an iron compound is prepared. This prophylactic/therapeutic agent can be used for ameliorating (preventing) depression in food consumption, water consumption and body weight, for ameliorating (decreasing) increase in ketone body levels in blood that may otherwise cause ketosis, for ameliorating (preventing) depression in ATP levels in blood, or for ameliorating (increasing) a survival rate and depression in a body surface temperature.


Patent
The Kitasato Institute, Tokushima University and Nobelpharma Co. | Date: 2015-11-04

The present invention to provide a novel pyruvate dehydrogenase kinase inhibitors. A pyruvate dehydrogenase kinase inhibitor comprising a compound represented by the general formula (I) as an active ingredient (wherein, ring A represents a 6-membered aromatic hydrocarbon ring optionally substituted with 2-4 substituents,R^(1) and R^(4), which are the same or different, represent a hydrogen atom, a hydroxyl group, an optionally substituted C1-6 alkyl group, R^(2) and R^(3), which are the same or different, represent a hydrogen atom, a carboxyl group, an optionally substituted C1-6 alkyl group, an optionally substituted C6-10 aryl group, or a group represented by -C (=R^(9))-R^(10)), a pharmaceutical composition for treatment or prophylaxis of diseases or disorders that pyruvate dehydrogenase kinase relates to its development or aggravation, and a cosmetic composition, and the like.


Patent
Tokushima University and Lsip Llc | Date: 2015-08-19

Provided is a radiation intensity measuring apparatus for each of small sealed radiation sources for cancer therapy capable of measuring multiple cartridges efficiently and rapidly. A radiation intensity measuring apparatus for radiation sources S in the state that the multiple radiation sources S are packed in a seed cartridge SC of a cartridge C, includes holding means 10 capable of holding the multiple cartridges C; radiation intensity measuring means 30 for measuring intensity of the radiation emitted from the multiple radiation sources S; and moving means 20 for moving the radiation intensity measuring means 30 toward or away from the holding means 10, and the radiation intensity measuring means 30 includes: a sensor 31 for measuring radiation intensity, and a shielding member 35 having a slit 35h provided for restricting radiation irradiated to the sensor 31; and the moving means 20 is configured to be able to relatively move the radiation intensity measuring means 30 along the direction in which the multiple radiation sources S are arranged in the measurement state.


Patent
Tokushima University, Meiji Pharmaceutical University and Lsip Llc | Date: 2015-08-26

Provided is a modified -subunit of human -hexosaminidase which has the activity derived from the -subunit of wild-type human -hexosaminidase and has the resistance to protease. A protein comprising an amino acid sequence having substitutions of the 312th to the 318th amino acids with glycine, serine, glutamic acid, proline, serine, glycine and threonine in order, respectively, in an amino acid sequence of a -subunit of wild-type human -hexosaminidase.


Hashimoto S.,Tokushima University
Journal of Physical Chemistry Letters | Year: 2011

This Perspective describes current research into the photochemistry of zeolites, pointing out issues yet to be resolved and suggesting future directions of investigation. The fascinating host materials are known to act as a support for guest ions, molecules, or clusters both within their large interior cage/channel networks and on their exterior surfaces, together providing rich chemistry. Two techniques have proven particularly successful for their study, diffuse reflectance transient absorption spectroscopy and optical microscopy. The various properties revealed by these techniques include intracrystalline and intercrystalline migration, migration-assisted photochemical reactions, and heterogeneous distribution of guest molecules among and within crystals. © 2011 American Chemical Society.


Patent
Tokushima University and Saisei Mirai Clinic | Date: 2015-01-21

An object of the present invention is to provide a pharmaceutical composition comprising an enzyme-treated human serum which is useful for treatment and prevention of diseases such as a cancer and an infectious disease, and a method of preparing the same. The present invention relates to a method of preparing a pharmaceutical composition comprising an enzyme-treated human serum, comprising a step of bringing the human serum into contact with -galactosidase and, to a pharmaceutical composition comprising an enzyme-treated human serum obtained by the preparation method.


Patent
Tokushima University | Date: 2014-07-09

A composition comprising the following composition: an AD vehicle including a synthetic peptide and a lipid, wherein the synthetic peptide includes the amino acid sequence KnLm (wherein n is 4 to 8 and m is 11 to 20), a carboxylvinyl polymer and an RSV antigen. The composition has an antibody producing ability which is further higher than that of a conventional mucosal vaccine, hence capable of exerting excellent anti-virus antigen-specific IgA antibody- and IgG antibody-inducing effect in the nasal wash and the serum, respectively, even with an extremely small quantity of an RSV antigen.


An object of the present invention is to provide a method for quickly acquiring three-dimensional shape data of upper and lower tooth rows. The present invention provides a method for calculating a distance between the upper and lower tooth rows at a high speed, from the three-dimensional shape data of the upper and lower tooth rows thus acquired. Based on technology behind the above methods, the present invention provides a method and an apparatus for performing simulation display of the three-dimensional shapes and an occlusal contact region of the upper and lower tooth rows at a high speed. A jaw movement sensor 30 is fitted to an examinee, and jaw movement data 35 on jaw movement of the examinee is acquired. An impression plate 20 including a rigid flat plate having a top surface and a bottom surface each coated with an impression material is inserted between upper and lower tooth rows of the examinee to which the jaw movement sensor 30 is fitted, and the examinee is guided to perform a temporary occlusion. Impressions left on the impression material 20 and a gauge mark provided on the rigid flat plate are measured by using a three-dimensional shape measuring instrument 25, whereby the three-dimensional shape data of the upper and lower tooth rows and gauge mark data are acquired. Simulation display of movement of the upper and lower tooth rows and occlusal contact regions of the examinee is performed based on the three-dimensional shape data of the upper and lower tooth rows and the gauge mark data, and jaw position data at a time of temporary occlusion and the jaw movement data.


Patent
Taiho Pharmaceutical Co and Tokushima University | Date: 2015-06-17

An object of the present invention is to provide an oxaliplatin-encapsulating liposome aqueous dispersion that has excellent long-term storage stability. The present invention provides an aqueous dispersion of liposomes encapsulating oxaliplatin, the oxaliplatin-encapsulating liposome aqueous dispersion containing 2-morpholinoethanesulfonic acid in an external aqueous phase.

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