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Tokushima, Japan

The University of Tokushima is a national university in the city of Tokushima, Japan, with seven graduate schools and five undergraduate faculties. The university was founded in 1949, by merging six national education facilities into one. The 2014 Nobel Prize Laureate in Physics, Shuji Nakamura graduated from Tokushima. Wikipedia.

Sato Y.,Tokushima University
Biology of reproduction | Year: 2013

Several studies have investigated whether particular Y chromosome haplogroups are associated with spermatogenic failure in Japanese males; however, they produced differing results. In this study, to investigate the association of Y chromosome haplogroup with spermatogenic failure, we recruited 451 infertile patients and 730 fertile men from a Japanese population and typed their Y chromosome haplogroups. The infertile patients were suffering from varicocele, azoospermia, oligozoospermia, asthenozoospermia, obstructive azoospermia, karyotype abnormalities, microdeletions of the long arm of the Y chromosome, or other conditions that affect fertility. The frequency of haplogroup D2* was significantly higher (odds ratio = 2.28, 95% confidence interval = 1.44-3.61, P = 0.00034 using chi-square test) among the men with azoospermia than among the fertile men. None of the other Y haplogroups displayed associations with particular types of infertility. In conclusion, Y chromosome haplogroup D2* is associated with spermatogenic failure in Japanese males, suggesting that the Y chromosome lineage can have significant effects on spermatogenesis. Source

Hashimoto S.,Tokushima University
Journal of Physical Chemistry Letters | Year: 2011

This Perspective describes current research into the photochemistry of zeolites, pointing out issues yet to be resolved and suggesting future directions of investigation. The fascinating host materials are known to act as a support for guest ions, molecules, or clusters both within their large interior cage/channel networks and on their exterior surfaces, together providing rich chemistry. Two techniques have proven particularly successful for their study, diffuse reflectance transient absorption spectroscopy and optical microscopy. The various properties revealed by these techniques include intracrystalline and intercrystalline migration, migration-assisted photochemical reactions, and heterogeneous distribution of guest molecules among and within crystals. © 2011 American Chemical Society. Source

Mima A.,Tokushima University
Therapeutic Apheresis and Dialysis | Year: 2012

Hemodialysis vascular access complications are one of the main causes associated with an increase in morbidity and hospitalization in hemodialysis (HD) patients. The most common cause of vascular access dysfunction is venous stenosis as a result of venous neointimal hyperplasia within the peri-anastomotic region (arteriovenous [AV] fistula) or at the graft-vein anastomosis. There have been few studies regarding effective therapeutic interventions for HD vascular dysfunction at the present time, despite the magnitude of the clinical problem. This review will focus initially on the pathology and pathogenesis of HD vascular access dysfunction in the setting of both native AV fistula and polytetrafluoroethylene (PTFE) graft, then experimental and clinical therapies that could potentially be used in the setting of HD vascular access dysfunction. © 2012 The Author. Therapeutic Apheresis and Dialysis © 2012 International Society for Apheresis. Source

Kagami S.,Tokushima University
Clinical and Experimental Nephrology | Year: 2012

Recently, there has been a paradigm shift away from an emphasis on the role of the endocrine (circulating) renin-Angiotensin system (RAS) in the regulation of the sodium and extracellular fluid balance, blood pressure, and the pathophysiology of hypertensive organ damage toward a focus on the role of tissue RAS found in many organs, including kidney. A tissue RAS implies that RAS components necessary for the production of angiotensin II (Ang II) reside within the tissue and its production is regulated within the tissue, independent of the circulating RAS. Locally produced Ang II plays a role in many physiological and pathophysiological processes such as hypertension, inflammation, oxidative stress, and tissue fibrosis. Both glomerular and tubular compartments of the kidney have the characteristics of a tissue RAS. The purpose of this article is to review the recent advances in tissue RAS research with a particular focus on the role of the glomerular RAS in the progression of renal disease. © Japanese Society of Nephrology 2012. Source

Abe M.,Tokushima University
International Journal of Hematology | Year: 2011

Cellular interplay in the bone marrow (BM) microenvironment in multiple myeloma (MM) mediates MM growth and the formation of bone-destructive lesions. MM cells show enhanced osteoclastogenesis, and stimulate angiogenesis in concert with BM stromal cells and osteoclasts, whereas they suppress osteoblastic differentiation, leading to devastating bone destruction and the rapid loss of bone. Importantly, osteoclasts, vascular endothelial cells, and BM stromal cells with defective osteoblastic differentiation create a cellular microenvironment suitable for MM growth and survival and confer a drug resistance to MM cells, which can be construed as the "MM niche". Therefore, the MM niche must be targeted and disrupted to improve the efficacy of anti-tumor treatment and prevent the progression of bone disease in MM. Clarifying molecular mechanisms leading to the formation of the MM niche along with bone disease will help in the development of novel approaches targeting the interplay between MM cells and the BM microenvironment. © 2011 The Japanese Society of Hematology. Source

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