Tokushima, Japan

Tokushima Bunri University
Tokushima, Japan

Tokushima Bunri University is a private university in Tokushima, Japan. Wikipedia.

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Minesaki Y.,Tokushima Bunri University
Astrophysical Journal | Year: 2017

We prove that the discrete-time general (1 + n)-body problem (d-G(1 + n)BP) proposed by Minesaki can exactly trace the orbits of elliptic relative equilibrium solutions in the original general (1 + n)-body problem (G(1 + n)BP). These orbits include the orbits of relative equilibrium solutions that have already been discovered. Before this proof, no discrete-time system had been shown to retain the orbits of elliptic relative equilibrium solutions in G(1 + n)BP. d-G(1 + n)BP can also precisely reproduce doubly symmetric orbits of the general (1 + 4)-body problem, each of which passes near a square equilibrium solution over a long time interval. © 2017. The American Astronomical Society. All rights reserved.

The terpenoid constituents of Ligularia virgaurea (30 samples), Ligularia pleurocaulis (8 samples), Ligularia dictyoneura (8 samples), Ligularia brassicoides (5 samples), Ligularia lingiana (1 sample), and Ligularia liatroides (1 sample)(all belonging to section Senecillis of Ligularia, Asteraceae and collected in Yunnan, Sichuan, Qinghai, and Gansu provinces, China), from which 220 compounds were isolated, including 113 novel ones, are reviewed. Five chemotypes were identified in L. virgaurea based on their chemical constituents, while three clades were detected from the base sequences. Although intra-specific diversity was found in L. virgaurea, more samples were needed of other species in order to reach a definite conclusion. Inter-specific diversity was also examined in section Senecillis but was restricted due to the scarcity of samples. Synthetic studies on chiral natural products to determine their absolute configurations, especially those of riccardiphenols A and B as well as crispatanolide, which were all isolated from the liverwort, are briefly reviewed. © 2016 The Pharmaceutical Society of Japan.

Shimamotot N.,Tokushima Bunri University
Yakugaku Zasshi | Year: 2013

Dysregulation of the production of reactive oxygen species (ROS) determines cellular function. Cytochrome P450s (CYPs) regulates ROS production and contributes to the process of cell death. This review summarizes our recent & findings, focusing on the involvement of CYPs in pathophysiology induced by ROS. 1. Quinone toxicity in hepatocytes: CYPs require electrons supplied from NADPH-cytochrome P450 reductase (NPR) during the process of metabolism. NPR also provides electrons to quinone compounds, which compete with CYPs over electrons. Inhibition of CYPs shifts NPR's electron ‰ow more to quinones, which accelerates the redox cycle to enhance ROS production and quinone toxicity. 2. Myocardial ischemia-reperfusion injury: Reperfusion of blood flow after coronary artery occlusion induces cell damage, as evident by the extension of myocardial infarct size and caspase-independent cell apoptosis. CYP2C6 appears to be a source for ROS production, since sulfaphenazole, a selective inhibitor of CYP2C6, reduces this damage. ROS produced by CYP2C6 during the reperfusion causes translational activation of Noxa and BimEL, as well as the suppression of caspase activation, resulting in caspase-independent apoptosis. 3. Primary hepatocyte apoptosis: Inhibition of catalase and glutathione peroxidase increases intracellular ROS and elicits caspase-independent hepatocyte apoptosis. SKF-525A, a pan-CYP inhibitor, suppresses these ROS increases and hepatocyte apoptosis. Increased ROS activates ERK and AP-1 by inhibition of tyrosine phosphatase, and inhibits BimEL degradation by proteasome. These results in the accumulation of mitochondrial BimEL, which then induces the release of cytochrome c and endonuclease G (En-doG). Increased ROS also keeps caspases inactivated. As a result, EndoG executes nucleosomal DNA fragmentation. © 2013 The Pharmaceutical Society of Japan.

Kasai H.,University of Tokyo | Kasai H.,Tokushima Bunri University | Takahashi N.,University of Tokyo | Takahashi N.,Tokushima Bunri University | And 2 more authors.
Physiological Reviews | Year: 2012

The dynamics of exocytosis are diverse and have been optimized for the functions of synapses and a wide variety of cell types. For example, the kinetics of exocytosis varies by more than five orders of magnitude between ultrafast exocytosis in synaptic vesicles and slow exocytosis in large dense-core vesicles. However, in all cases, exocytosis is mediated by the same fundamental mechanism, i.e., the assembly of soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins. It is often assumed that vesicles need to be docked at the plasma membrane and SNARE proteins must be preassembled before exocytosis is triggered. However, this model cannot account for the dynamics of exocytosis recently reported in synapses and other cells. For example, vesicles undergo exocytosis without prestimulus docking during tonic exocytosis of synaptic vesicles in the active zone. In addition, epithelial and hematopoietic cells utilize cAMP and kinases to trigger slow exocytosis of nondocked vesicles. In this review, we summarize the manner in which the diversity of exocytosis reflects the initial configurations of SNARE assembly, including trans-SNARE, binary-SNARE, unitary-SNARE, and cis-SNARE configurations. The initial SNARE configurations depend on the particular SNARE subtype (syntaxin, SNAP25, or VAMP), priming proteins (Munc18, Munc13, CAPS, complexin, or snapin), triggering proteins (synaptotagmins, Doc2, and various protein kinases), and the submembraneous cytomatrix, and they are the key to determining the kinetics of subsequent exocytosis. These distinct initial configurations will help us clarify the common SNARE assembly processes underlying exocytosis and membrane trafficking in eukaryotic cells. © 2012 the American Physiological Society.

Setaka W.,Tokushima Bunri University | Setaka W.,Japan Science and Technology Agency | Yamaguchi K.,Tokushima Bunri University
Journal of the American Chemical Society | Year: 2012

A macrocage molecule with a bridged phenylene rotor has been reported as a molecular gyrotop, because the rotor can rotate even in a crystalline state. Although the most stable cage structure of the molecular gyrotop in a crystal was folded and shrunken at low temperature, expansion of the cage was observed at high temperature due to rapid rotation of the phenylene in a crystal. This phenomenon is analogous to the deflation and inflation of a balloon. Moreover, the unusually large thermal expansion coefficient of the crystal was estimated in the temperature range in which the expansion of the cage was observed, indicating a new function of dynamic states of the molecules. © 2012 American Chemical Society.

Mukai R.,Tokushima Bunri University | Ohshima T.,Tokushima Bunri University
Oncogene | Year: 2014

Human T-cell leukemia virus type-1 (HTLV-1) infection causes adult T-cell leukemia (ATL). Modulation of the transcriptional control of cellular genes by HTLV-1 is thought to be associated with the development of ATL. The viral protein HTLV-1 basic leucine-zipper factor (HBZ) has been shown to dysregulate the activity of cellular transcription factors. Here, we demonstrate that HBZ is exported from the nucleus to the cytoplasm, where it activates the mammalian target of rapamycin (mTOR) signaling pathway through an association with growth arrest and DNA damage gene 34 (GADD34). The N-terminal region of HBZ interacts with the C-terminal region of GADD34. HBZ contains a functional nuclear export signal (NES) sequence within its N-terminal region and it is exported from the nucleus via the CRM1-dependent pathway. Nuclear export of HBZ is essential for its interaction with GADD34 and increased phosphorylation of S6 kinase, which is an established downstream target of the mTOR pathway. Starvation-induced autophagy is significantly suppressed by the overexpression of HBZ. These findings indicate that HBZ is actively exported to the cytoplasm, where it dysregulates the function of cellular factors.

Setaka W.,Tokyo Metroplitan University | Yamaguchi K.,Tokushima Bunri University
Journal of the American Chemical Society | Year: 2013

Successful control of the orientation of the π-electron systems in media has been achieved in certain liquid crystals, making them applicable to devices for optical systems because of the variation in the optical properties with the orientation of the π-electron system. However, because of close packing, changing the orientation of molecules in the crystalline state is usually difficult. A macrocage molecule with a bridged thiophene rotor was synthesized as a molecular gyrotop having a dipolar rotor, given that the dipole derived from the thiophene can rotate even in the crystal. The thermally induced change in the orientation of the dipolar rotors (thiophene ring) inside the crystal, i.e., order-disorder transition, and the variation in the optical properties in the crystalline state were observed. © 2013 American Chemical Society.

For the restricted three-body problem, we propose an accurate orbital integration scheme that retains all conserved quantities of the two-body problem with two primaries and approximately preserves the Jacobi integral. The scheme is obtained by taking the limit as mass approaches zero in the discrete-time general three-body problem. For a long time interval, the proposed scheme precisely reproduces various periodic orbits that cannot be accurately computed by other generic integrators. © 2013. The American Astronomical Society. All rights reserved. Printed in the U.S.A.

Minesaki Y.,Tokushima Bunri University
Astronomical Journal | Year: 2013

We propose an accurate orbital integration scheme for the general three-body problem that retains all conserved quantities except angular momentum. The scheme is provided by an extension of the d'Alembert-type scheme for constrained autonomous Hamiltonian systems. Although the proposed scheme is merely second-order accurate, it can precisely reproduce some periodic, quasiperiodic, and escape orbits. The Levi-Civita transformation plays a role in designing the scheme. © 2013. The American Astronomical Society. All rights reserved.

Minesaki Y.,Tokushima Bunri University
Astronomical Journal | Year: 2013

There is no known integrator that yields exact orbits for the general three-body problem (G3BP). It is difficult to verify whether a numerical procedure yields the correct solutions to the G3BP because doing so requires knowledge of all 11 conserved quantities, whereas only six are known. Without tracking all of the conserved quantities, it is possible to show that the discrete general three-body problem (d-G3BP) yields the correct orbits corresponding to Lagrange solutions of the G3BP. We show that the d-G3BP yields the correct solutions to the G3BP for two special cases: the equilateral triangle and collinear configurations. For the triangular solution, we use the fact that the solution to the three-body case is a superposition of the solutions to the three two-body cases, and we show that the three bodies maintain the same relative distances at all times. To obtain the collinear solution, we assume a specific permutation of the three bodies arranged along a straight rotating line, and we show that the d-G3BP maintains the same distance ratio between two bodies as in the G3BP. Proving that the d-G3BP solutions for these cases are equivalent to those of the G3BP makes it likely that the d-G3BP and G3BP solutions are equivalent in other cases. To our knowledge, this is the first work that proves the equivalence of the discrete solutions and the Lagrange orbits. © 2013. The American Astronomical Society. All rights reserved.

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