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Kakamigahara, Japan

Tokai Gakuin University is a private university in Kakamigahara, Gifu Prefecture, Japan. The predecessor of the school, founded in 1961, was chartered as Tokai Women's College in 1981. In 2007, the school adopted the present name. Wikipedia.

Arakaki N.,Okinawa Prefectural Agricultural Research Center | Yamazawa H.,Japan National Institute of Agrobiological Science | Yamazawa H.,Tokai Gakuin University | Wakamura S.,Japan National Institute of Agrobiological Science | Wakamura S.,Kyoto Gakuen University
Applied Entomology and Zoology | Year: 2011

Egg parasitoids Telenomus euproctidis Wilcox (Hymenoptera: Scelionidae) were attracted to egg masses laid by wingless immobile female Orgyia postica (Lepidoptera: Lymantriidae). Virgin females, a solvent extract of pheromone glands, and a synthetic sex pheromone, (6Z,9Z,11S,12S)-11,12-epoxyhenicosa-6,9-diene (posticlure), also attracted this parasitoid in the field, demonstrating that T. euproctidis uses the sex pheromone of female Org. postica as a kairomone to locate host eggs. © 2011 The Japanese Society of Applied Entomology and Zoology. Source

Iio A.,Gifu International Institute of Biotechnology | Ohguchi K.,Gifu International Institute of Biotechnology | Ohguchi K.,Sugiyama Jogakuen University | Iinuma M.,Gifu Pharmaceutical University | And 3 more authors.
Journal of Natural Products | Year: 2012

ABCA1, a member of the ATP-binding cassette transporter family, regulates high-density lipoprotein (HDL) metabolism and cholesterol transport. Its expression is upregulated mainly by the activation of the liver X receptor (LXR). Since ABCA1 plays a pivotal role in cholesterol and HDL metabolism, identification of a compound capable of increasing its expression may be beneficial for the prevention and therapy of atherosclerosis. Firefly luciferase reporter assays were developed for human ABCA1 promoters and LXR enhancers, and an in-house phytochemical library was screened. It was found that a citrus flavonoid, hesperetin (1), increased ABCA1 promoter and LXR enhancer activities in THP-1 macrophages. It was also found that this flavonoid promoted PPAR-enhancing activity. In accordance with these findings, 1 increased mRNA and protein expression of ABCA1 and consequently upregulated ApoA-I-mediated cholesterol efflux. These results provide evidence that 1 promotes ApoA-I-mediated cholesterol efflux from macrophages by increasing ABCA1 expression through the activation of LXRα and PPARγ. © 2012 The American Chemical Society and American Society of Pharmacognosy. Source

Hasegawa A.,Tokai Gakuin University | Hattori Y.,Kyoto Gakuen University | Nishimura H.,University of Tsukuba | Tanno Y.,University of Tokyo
Psychological Reports | Year: 2015

The main purpose of this study was to examine whether depressive rumination and social problem solving are prospectively associated with depressive symptoms. Nonclinical university students (N = 161, 64 men, 97 women; M age = 19.7 yr., SD = 3.6, range = 18–61) recruited from three universities in Japan completed the Beck Depression Inventory–Second Edition (BDI–II), the Ruminative Responses Scale, Social Problem-Solving Inventory–Revised Short Version (SPSI– R:S), and the Means–Ends Problem-Solving Procedure at baseline, and the BDI–II again at 6 mo. later. A stepwise multiple regression analysis with the BDI–II and all subscales of the rumination and social problem solving measures as independent variables indicated that only the BDI–II scores and the Impulsivity/carelessness style subscale of the SPSI–R:S at Time 1 were signifi cantly associated with BDI–II scores at Time 2 (β = 0.73, 0.12, respectively; independent variables accounted for 58.8% of the variance). These fi ndings suggest that in Japan an impulsive and careless problem-solving style was prospectively associated with depressive symptomatology 6 mo. later, as contrasted with previous fi ndings of a cycle of rumination and avoidance problem-solving style. © Psychological Reports 2015. Source

Inada N.,National Institute of Mental Health | Koyama T.,National Institute of Mental Health | Inokuchi E.,National Institute of Mental Health | Kuroda M.,National Institute of Mental Health | And 2 more authors.
Research in Autism Spectrum Disorders | Year: 2011

Early detection and intervention is essential for children with autism spectrum disorders (ASD). Therefore, we examined the reliability and validity of the Japanese version of the Modified Checklist for autism in toddlers (M-CHAT), a 23-item, yes-no questionnaire regarding early autistic symptoms completed by parents of children at 18-24 months of age. Herein, the reliability of the M-CHAT was investigated for children 4-20 months of age. The M-CHAT score (the number of failed items) was found to be significantly correlated among 24 mother-father pairs (Pearson's r = .933), representing good inter-rater reliability. The test-retest reliability was satisfactory, with 22 mothers providing almost equal M-CHAT scores on two different occasions (r = .990). Significant correlations were observed between the M-CHAT score and the Childhood Autism Rating Scale-Tokyo version score in 25 two-year-old children (r = .581), indicating good concurrent validity. The M-CHAT score was significantly higher in 20 children later diagnosed with ASD compared with reference children (n = 1167), revealing sufficient discriminant validity. A short version of the M-CHAT using 9 items was proposed and effectively differentiated children with ASD from reference children. The efficacy of the Japanese version of the M-CHAT was demonstrated for first-level screening in the general population. © 2011 Elsevier Ltd. Source

Kojima K.,Gifu University | Kojima K.,Gifu International Institute of Biotechnology | Fujita Y.,Gifu International Institute of Biotechnology | Nozawa Y.,Gifu International Institute of Biotechnology | And 3 more authors.
Prostate | Year: 2010

BACKGROUND Patients with hormone-refractory prostate cancer are treated with taxane drugs, but eventually become drug resistant. We aimed to elucidate the molecular mechanisms underlying paclitaxel resistance of hormone-refractory prostate cancer with a special focus on the roles of miR-34a and SIRT1. METHODS Paclitaxel-resistant cells (PC3PR) were generated from hormone-refractory PC3 cells. The expression levels of mRNA and miRNA were determined by reverse transcriptase PCR and those of protein were by Western blot analysis. Transfection of miRNA precursor or siRNA was performed using the liposome-mediated method. RESULTS MiR-34a over-expression and SIRT1 knockdown attenuated paclitaxel resistance of PC3PR cells. MiR-34a expression was reduced in PC3PR cells compared with PC3 cells, while the expression levels of HuR and Bcl2 as well as SIRT1 were elevated in PC3PR cells. Luciferase reporter assays revealed that both SIRT1 3′-UTR and promoter activities were higher in PC3PR cells than in PC3 cells. Introduction of miR-34a precursor into PC3PR cells resulted in decreases in HuR, Bcl2, and SIRT1 expression and inhibition of the SIRT1 3′-UTR activity. HuR knockdown reduced SIRT1 and Bcl2 expression. These results suggest that miR-34a not only directly but also indirectly via regulating HuR expression acts on the 3′-UTR of SIRT1 and Bcl2 mRNAs, thereby controlling their expression. Thus, in PC3PR cells, reduced expression of miR-34a confers paclitaxel resistance via up-regulating SIRT1 and Bcl2 expression. CONCLUSIONS MiR-34a and its downstream targets SIRT1 and Bcl2 play important roles in the development of paclitaxel resistance, all of which can be useful biomarkers and promising therapeutic targets for the drug resistance in hormone-refractory prostate cancer. © 2010 Wiley-Liss, Inc. Source

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