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Hirosaki, Japan

Tohoku Women's College is a private women's college in the city of Hirosaki, Aomori prefecture, Japan, established in 1969. The predecessor of the school was founded in 1923 Wikipedia.

Tsuchiya Y.,Tohoku Womens College
Journal of Cell Science | Year: 2016

The Cu+ pump ATP7B plays an irreplaceable role in the elimination of excess Cu+ by the hepatocyte into the bile. The trafficking and site of action of ATP7B are subjects of controversy. One current proposal is that an increase in intracellular Cu+ results in the translocation of ATP7B to the lysosomes and excretion of excess Cu+ through lysosomal-mediated exocytosis at the bile canaliculus. Here, we show that ATP7B is transported from the trans-Golgi network (TGN) to the bile canaliculus by basolateral sorting and endocytosis, and microtubule-mediated transcytosis through the subapical compartment. Trafficking ATP7B is not incorporated into lysosomes, and addition of Cu+ does not cause relocalization of lysosomes and the appearance of lysosome markers in the bile canaliculus. Our data reveal the pathway of the Cu+-mediated transport of ATP7B from the TGN to the bile canaliculus and indicates that the bile canaliculus is the primary site of ATP7B action in the elimination of excess Cu+. © 2016. Published by The Company of Biologists Ltd. Source

Tohoku Womens College | Entity website

718 2370 11

Tohoku Womens College | Entity website

Tohoku Womens College | Entity website

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Tohoku Womens College | Entity website

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